Protein

MIA_04481_1

Length
450 amino acids

Browser: contig06:147038-148391-

Protein function

EGGNOG:0PJIRTEF1This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SGD closest match:S000006284TEF1Elongation factor 1-alpha
CGD closest match:CAL0000196876TEF2Elongation factor 1-alpha 2

Protein alignments

%idAln lengthE-value
UniRef50_A0A1B7NBY749.771%4361.85e-149Elongation factor 1-alpha n=1787 Tax=Fungi TaxID=4751 RepID=A0A1B7NBY7_9HOMO
A0A1E4TA38_9ASCO49.533%4281.70e-152Elongation factor 1-alpha OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_52543 PE=3 SV=1
A0A060T453_BLAAD49.528%4243.27e-151Elongation factor 1-alpha OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C01892g PE=3 SV=1
EF1A_YEAST49.543%4381.26e-150Elongation factor 1-alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEF1 PE=1 SV=1
EF1A2_CANAL49.057%4248.29e-151Elongation factor 1-alpha 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TEF2 PE=3 SV=2
EF1A_YARLI49.412%4253.62e-148Elongation factor 1-alpha OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TEF PE=2 SV=2
MCA_04441_247.170%4241.33e-147MCA_04441_2
A0A167DIZ3_9ASCO45.872%3277.95e-99Translation elongation factor EF-1 alpha OS=Sugiyamaella lignohabitans GN=TEF1 PE=4 SV=1
A0A1E3PL22_9ASCO54.656%2471.51e-97Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_41536 PE=4 SV=1
I3Y136_GEOCN46.179%3018.42e-88Translation elongation factor 1-alpha (Fragment) OS=Geotrichum candidum PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0472

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 450

Detailed signature matches

  1. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  2. Domain IPR000795
    Transcription factor, GTP-binding domain
    1. PS51722 (G_TR_2)
    2. PF00009 (GTP_EFTU)
    3. PR00315 (ELONGATNFCT)
  3. Domain IPR009000
    Translation protein, beta-barrel domain
    1. SSF50447 (Translati...)
  4. Domain IPR004161
    Translation elongation factor EFTu-like, domain 2
    1. PF03144 (GTP_EFTU_D2)
  5. Domain IPR009001
    Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    1. SSF50465 (EF-Tu/eEF...)
  6. Domain IPR004160
    Translation elongation factor EFTu/EF1A, C-terminal
    1. PF03143 (GTP_EFTU_D3)
  7. SITE IPR031157
    Tr-type G domain, conserved site
    1. PS00301 (G_TR_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.30.10
  2. G3DSA:3.40.50...
  3. cd01883 (EF1_alpha)
  4. cd03693 (EF1_alpha_II)

Residue annotation

  1. G1 box cd01883
  2. putative GEF inter...
  3. GTP/Mg2+ binding s...
  4. EF1Balpha binding ...
  5. Switch I region cd...
  6. G2 box cd01883
  7. G3 box cd01883
  8. Switch II region c...
  9. G4 box cd01883
  10. G5 box cd01883
  11. pelota interface c...
  12. EF1 beta interface...
  13. 18S rRNA binding s...

Protein sequence

>MIA_04481_1
MKSAKKLHINIVAIGQVDSGKSTTLGRLIYECGGVDEETMDKLEIEASEIGKGSFKYAWIFDTLKAERERGITIEISHQI
FETPSSQITLIDVPGHRRFFKNMLTGASQADCALVVVSADEDEFETCMSEDGQLKDHLQAVHDFGIKEVIVVVNKMDSIN
WSEDRFANIVSQVQDTLKAVSFWTDQVPIIPISGWNGDNLTTASTNCPWYHGWTKTRMGVTSSGTTLLDAINSIQRIYYT
LYKPLRIPIERVYNIGGIGTVPVGTVSSGTLRPGMSVTFAPSLLTSEVKSIEMGHKPLLEAGPGDNIGFNIGDVDANKIK
PGYVAGDFDGNLNLEVMNFLATIVIINHPGSISSLYTPIFDFRSGHVACKITSLIHTLEKNTNHLLESSPASISQGERCI
VQVVPCKPIYIQSYNENPCLGRFVIRDLGKIVGVGVVKTINYQRPDSEEP

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component

None predicted.