Protein

MIA_04476_1

Length
594 amino acids

Browser: contig06:137387-139172-

Protein function

EGGNOG:0PGHWFG08715.1d-lactate dehydrogenase
SGD closest match:S000002333DLD1D-lactate dehydrogenase [cytochrome] 1, mitochondrial
CGD closest match:CAL0000175340DLD1Dld1p

Protein alignments

%idAln lengthE-value
MCA_06433_172.674%5160.0MCA_06433_1
A0A0J9X9H2_GEOCN69.215%4970.0Similar to Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase, oxidizes D-lactate to pyruvate,transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate OS=Geotrichum candidum GN=BN980_GECA06s04828g PE=4 SV=1
A0A167CKJ9_9ASCO65.714%4900.0Dld1p OS=Sugiyamaella lignohabitans GN=DLD1 PE=4 SV=1
UniRef50_A0A167CKJ965.714%4900.0Dld1p n=326 Tax=Fungi TaxID=4751 RepID=A0A167CKJ9_9ASCO
A0A1E3PLT7_9ASCO65.164%4880.0FAD-binding domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82226 PE=4 SV=1
A0A060T9L5_BLAAD63.200%5000.0ARAD1D16016p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D16016g PE=4 SV=1
Q6C773_YARLI55.579%4750.0YALI0E03212p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E03212g PE=4 SV=1
A0A1E4TKE1_9ASCO50.620%4842.97e-169Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_802 PE=4 SV=1
DLD1_YEAST47.738%4421.56e-130D-lactate dehydrogenase [cytochrome] 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DLD1 PE=1 SV=2
A0A1D8PGR9_CANAL44.685%4612.17e-119Dld1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DLD1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9985
Predicted cleavage: 34

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 594

Detailed signature matches

  1. Domain IPR016167
    FAD-binding, type 2, subdomain 1
    1. G3DSA:3.30.43.10
  2. Domain IPR016166
    FAD-binding, type 2
    1. PS51387 (FAD_PCMH)
    2. SSF56176 (FAD-bindi...)
  3. Domain IPR006094
    FAD linked oxidase, N-terminal
    1. PF01565 (FAD_binding_4)
  4. Domain IPR016169
    CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
    1. G3DSA:3.30.46...
  5. Domain IPR016164
    FAD-linked oxidase-like, C-terminal
    1. SSF55103 (FAD-linke...)
  6. Domain IPR004113
    FAD-linked oxidase, C-terminal
    1. PF02913 (FAD-oxidase_C)
  7. Domain IPR016171
    Vanillyl-alcohol oxidase, C-terminal subdomain 2
    1. G3DSA:1.10.45.10
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TRANSMEMBRANE (Tran...)

Protein sequence

>MIA_04476_1
MNFSGFMRLTRSVPKVRSIQPLSRPFSKNASQQASFQKTKQPSFSSVTLIVSFISAAAASAATYYYAKSEFRDESILRPE
SINKFWPIRKYGGATELALALPEFQEFLDDRVTTDPEELKRHGYSDWSTINIERNPIAIVYPTSTEEVSRIAKICHKYKL
PMIGFSGGSSLEGNFSAPHGGICIDFSHMNTIIEIRPDDLDATVQPGVGWMDLNQHLKSNGINLFFPVDPGPIAKIGGMV
STSCSGTNCVRYGPMRDHIVNLTVVLVDGTIIKTRGRPRKTSAGYNLNHLFAGSEGTLGLITEITVKLAVVPEHTTVALS
TFPSERLATSAAIGIIRAGIPIHCVELMDDVQMWAINKSNSTERKWKEQATLLFKFSGSKAFVNEQIEKARQVASKYQSS
SFDFARNDDEAQKIWAARKEALWSSMALGPKDAKIYTTDVAVPMSKLADLIEATKKDLKDSGVAFGSSLGHVGDGNFHAS
VIYNDTPEEAKVAKQIAENVNYRGLALEGTCTGEHGVGMGKVKYLADELGTDVINIMHTIKMALDPYELLNPGKIFTREA
TEWAAEKERNGTWGGKGFKLHHFGEPLQSTDINK

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

None predicted.