Protein

MIA_04475_1

Length
421 amino acids

Browser: contig06:132936-134202-

Protein function

EGGNOG:0PJIRTEF1This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SGD closest match:S000006284TEF1Elongation factor 1-alpha
CGD closest match:CAL0000196876TEF2Elongation factor 1-alpha 2

Protein alignments

%idAln lengthE-value
A0A060T453_BLAAD53.957%4174.37e-166Elongation factor 1-alpha OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C01892g PE=3 SV=1
EF1A2_CANAL54.197%4171.96e-164Elongation factor 1-alpha 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TEF2 PE=3 SV=2
UniRef50_P0CY3554.197%4174.75e-161Elongation factor 1-alpha 1 n=2464 Tax=cellular organisms TaxID=131567 RepID=EF1A1_CANAL
EF1A_YEAST53.606%4161.40e-163Elongation factor 1-alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEF1 PE=1 SV=1
A0A1E4TA38_9ASCO52.758%4171.98e-161Elongation factor 1-alpha OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_52543 PE=3 SV=1
EF1A_YARLI53.349%4181.21e-159Elongation factor 1-alpha OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TEF PE=2 SV=2
MCA_04441_252.038%4171.84e-158MCA_04441_2
A0A167DIZ3_9ASCO50.292%3429.76e-118Translation elongation factor EF-1 alpha OS=Sugiyamaella lignohabitans GN=TEF1 PE=4 SV=1
I3Y136_GEOCN50.842%2975.79e-100Translation elongation factor 1-alpha (Fragment) OS=Geotrichum candidum PE=4 SV=1
A0A1E3PL22_9ASCO53.304%2276.01e-84Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_41536 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0259

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 421

Detailed signature matches

  1. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  2. Domain IPR000795
    Transcription factor, GTP-binding domain
    1. PS51722 (G_TR_2)
    2. PF00009 (GTP_EFTU)
    3. PR00315 (ELONGATNFCT)
  3. Domain IPR009000
    Translation protein, beta-barrel domain
    1. SSF50447 (Translati...)
  4. Domain IPR004161
    Translation elongation factor EFTu-like, domain 2
    1. PF03144 (GTP_EFTU_D2)
  5. Domain IPR009001
    Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    1. SSF50465 (EF-Tu/eEF...)
  6. Domain IPR004160
    Translation elongation factor EFTu/EF1A, C-terminal
    1. PF03143 (GTP_EFTU_D3)
  7. SITE IPR031157
    Tr-type G domain, conserved site
    1. PS00301 (G_TR_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.30.10
  2. G3DSA:3.40.50...
  3. cd03693 (EF1_alpha_II)
  4. cd03705 (EF1_alpha_III)

Residue annotation

  1. pelota interface c...
  2. EF1 beta interface...
  3. 18S rRNA binding s...
  4. pelota interface c...
  5. heterodimer interf...

Protein sequence

>MIA_04475_1
MYKCGEVDKETIDNLENEASEIGKGSFKYAWVFDKLKAERERGITIDISQQKFETPKHIVTIIDTPGHKDYTKNFLTGVS
QADIVLIIVPAKEDELEAALSKKGKLREQLLAAYSFQVKKFIIAVNKMDSVNWSESAFKNAVSSTRSILKIIGINIRYVP
FVPISGWNGDNLVEPSPFSTWFNESSDYYTNDYFRKTLFDTIDAFDAPARPSGKPLRIPVENVYNIENIGTVPVGCISTG
VLKPGMFVTFAPTQLTSEVKSIEMYHEPLDEAVPGDNIGFNIDDIDVSEIKRGYVAGQFDNYQPLITAYFIADITVINHP
GQIHPGYTPIVDCHTAHVACKFAELITTIDPRTGQPLENGPKYLKQGDTAMVKLYPAKPMYIEDMASFPSLGSLVIRDLG
KIVAVGVVKSVERSDEFTPLD

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component

None predicted.