Protein

MIA_04425_1

Length
402 amino acids

Browser: contig05:1673599-1674808-

Protein function

EGGNOG:0PHY1ILV5ketol-acid reductoisomerase
SGD closest match:S000004347ILV5Ketol-acid reductoisomerase, mitochondrial
CGD closest match:CAL0000180692ILV5Ketol-acid reductoisomerase, mitochondrial

Protein alignments

%idAln lengthE-value
A0A0J9XDR2_GEOCN89.552%4020.0Ketol-acid reductoisomerase, mitochondrial OS=Geotrichum candidum GN=BN980_GECA12s00527g PE=3 SV=1
MCA_02607_188.366%4040.0MCA_02607_1
A0A167C5P5_9ASCO91.453%3510.0Ketol-acid reductoisomerase, mitochondrial OS=Sugiyamaella lignohabitans GN=ILV5 PE=3 SV=1
Q6CAF8_YARLI90.313%3510.0Ketol-acid reductoisomerase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D03135g PE=3 SV=1
A0A060TBD1_BLAAD89.143%3500.0Ketol-acid reductoisomerase, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D27060g PE=3 SV=1
UniRef50_A0A0G2GD9685.227%3520.0Putative ketol-acid reductoisomerase n=1 Tax=Phaeomoniella chlamydospora TaxID=158046 RepID=A0A0G2GD96_9EURO
A0A1E3PH12_9ASCO86.571%3500.0Ketol-acid reductoisomerase, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83492 PE=3 SV=1
ILV5_YEAST86.819%3490.0Ketol-acid reductoisomerase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ILV5 PE=1 SV=1
A0A1D8PPG7_CANAL85.100%3490.0Ketol-acid reductoisomerase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ILV5 PE=3 SV=1
A0A1E4TCP6_9ASCO81.250%3520.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_27601 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9999
Predicted cleavage: 57

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 402

Detailed signature matches

  1. Family IPR013023
    Ketol-acid reductoisomerase
    1. TIGR00465
  2. Family IPR016207
    Ketol-acid reductoisomerase, fungi
    1. PIRSF000119 (Ilv5_f...)
  3. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  4. Domain IPR013116
    Acetohydroxy acid isomeroreductase, NADPH-binding domain
    1. PF07991 (IlvN)
  5. Domain IPR013328
    6-phosphogluconate dehydrogenase, domain 2
    1. G3DSA:1.10.10...
  6. Domain IPR000506
    Acetohydroxy acid isomeroreductase C-terminal
    1. PF01450 (IlvC)
  7. Domain IPR008927
    6-phosphogluconate dehydrogenase C-terminal domain-like
    1. SSF48179 (6-phospho...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)

Protein sequence

>MIA_04425_1
MSARQSIRILRSTAARSVIRSAASKRAFTALAVAATRPAVAAAAPIRPIVQQRGLKSINFGGTEEVVHERGDWPREKLLD
YFKNDTLALIGYGSQGYGQGLNLRDNGINVIIGVRKDGASWKAAIEDGWVPGKNLFDVDTAIQKGTIVMNLLSDAAQSET
WPHIKPLLTKGKTLYFSHGFSPVFKDLTKVETPKDIDVILVAPKGSGRTVRSLFKEGRGINSSYAVWQDVTGKAEEKAIA
LAVAVGSGYIYKTTFEKEVRSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGKYGMDYMY
DACSTTARRGALDWSPKFKDALKPVFNELYDRVVDGSETKRSLEFNSQPDYRDKFEKELQEIRDLEIWRVGKEVRKLRPE
NN

GO term prediction

Biological Process

GO:0009082 branched-chain amino acid biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004455 ketol-acid reductoisomerase activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.