Protein

MIA_04226_1

Length
616 amino acids

Browser: contig05:1121131-1122982+

Protein function

EGGNOG:0PGGHFG09572.1Methylenetetrahydrofolate reductase
SGD closest match:S000003093MET13Methylenetetrahydrofolate reductase 2
CGD closest match:CAL0000177037MET13Methylenetetrahydrofolate reductase

Protein alignments

%idAln lengthE-value
MCA_06338_172.816%6180.0MCA_06338_1
A0A161HNG2_9ASCO67.044%6190.0Methylenetetrahydrofolate reductase OS=Sugiyamaella lignohabitans GN=MET13 PE=3 SV=1
A0A0J9XG79_GEOCN67.152%6180.0Methylenetetrahydrofolate reductase OS=Geotrichum candidum GN=BN980_GECA14s02826g PE=3 SV=1
A0A060TI73_BLAAD63.548%6200.0Methylenetetrahydrofolate reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D44198g PE=3 SV=1
Q6CG63_YARLI63.149%6160.0Methylenetetrahydrofolate reductase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B00572g PE=3 SV=1
A0A1E4TAE8_9ASCO60.353%6230.0Methylenetetrahydrofolate reductase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_128000 PE=3 SV=1
A0A1E3PJM3_9ASCO62.136%6180.0Methylenetetrahydrofolate reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47079 PE=3 SV=1
UniRef50_A0A1U7LVH956.260%6150.0Methylenetetrahydrofolate reductase 1 n=1 Tax=Neolecta irregularis DAH-3 TaxID=1198029 RepID=A0A1U7LVH9_9ASCO
MTHR2_YEAST53.670%6130.0Methylenetetrahydrofolate reductase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET13 PE=1 SV=2
Q5AEI0_CANAL51.496%6350.0Methylenetetrahydrofolate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MET13 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2809

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 616

Detailed signature matches

  1. Family IPR003171
    Methylenetetrahydrofolate reductase
    1. PF02219 (MTHFR)
    2. cd00537 (MTHFR)
  2. Family IPR004621
    Eukaryotic-type methylenetetrahydrofolate reductase
    1. TIGR00677
  3. Domain IPR029041
    FAD-linked oxidoreductase-like
    1. SSF51730 (FAD-linke...)
    2. G3DSA:3.20.20...
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Residue annotation

  1. FAD binding site c...

Protein sequence

>MIA_04226_1
MKISQKLAQAHSGPLASRPTYSFEYFVPKTTQGVQNLYDRMDRMYDLGPAFIDVTWNAGGSSEAPSANNLTTEIVATAQG
ILGLETCMHLTCTGMPKETVEAALEQAYKAGCQNILALRGDKAEGKADDDQDTFVYAKDLIRFIRNKYGDYFDICVAGYP
EGHPEEPDPKVLIKYLKEKVDAGANFVITQMFYNVDTFLAWVDQCRDAGITVPIIPGIMPISTYASFLRRANWCQVDIPK
HFLEALEPIKGDDAQVREVGTQLVADMCRKMLAHGINHLHFYTMNLERATMMILESLALLDQSPALTPQEDRPASASSVS
STASSLKVNNPPLPWRQSLGLTRKEESVRPIFWKNRKHSYVARTQDWDEFPNGRWGDSRSPAYGELERYGGVMRQSASRA
REIWGQPATYRELASTFVRYLNGKTASLPWSDSPISAEVDEIKPQLIDLNTRGILTINSQPSVNGVSSTHPIHGWGPAHG
YVYQKAYLELLVPGPIADKIIEQITQDPQITYYAVDNAGHLETNAPENGGPNAVTWGIYPGHEVIQPTIVEKISFLAWKD
EAFKLAHEWARCCDKDSPAQALLNQVADEWKLINIVHNDFQSTHKIFDALAGISAF

GO term prediction

Biological Process

GO:0006555 methionine metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity

Cellular Component

None predicted.