MIA_04177_1

Protein

Length

452 amino acids

Protein function

EGGNOG:	0PFHA	FG03396.1	(Mfs) transporter
SGD closest match:	S000003885	YJR124C	Uncharacterized membrane protein YJR124C
CGD closest match:	CAL0000188365	orf19.4780	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
A0A0J9XIV9_GEOCN	55.257%	447	1.80e-158	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA20s01759g PE=4 SV=1
A0A060T8F0_BLAAD	49.431%	439	1.39e-133	ARAD1D03124p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D03124g PE=4 SV=1
Q6C745_YARLI	49.550%	444	7.34e-132	YALI0E03872p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E03872g PE=4 SV=1
UniRef50_Q6C745	49.550%	444	1.70e-128	YALI0E03872p n=6 Tax=Saccharomycetales TaxID=4892 RepID=Q6C745_YARLI
A0A1E3PCU1_9ASCO	48.444%	450	1.21e-120	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48136 PE=4 SV=1
A0A167CXG8_9ASCO	48.409%	440	1.33e-118	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_474 PE=4 SV=1
Q5API4_CANAL	41.295%	448	1.59e-114	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4780 PE=4 SV=1
YJ94_YEAST	35.748%	428	3.39e-74	Uncharacterized membrane protein YJR124C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YJR124C PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2162

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
1 - 446
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 452

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  28 - 364
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  1 - 446
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  22 - 439
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  24 - 430
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

105 - 110

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

179 - 189

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

50 - 60

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

292 - 302

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

365 - 452

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

13 - 235

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

256 - 450

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

79 - 83

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

133 - 151

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

326 - 344

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1 - 23

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

213 - 265

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

153 - 175

TMHMM
TMhelix (TMhelix)

340 - 362

TMHMM
TMhelix (TMhelix)

110 - 132

TMHMM
TMhelix (TMhelix)

59 - 81

TMHMM
TMhelix (TMhelix)

190 - 212

TMHMM
TMhelix (TMhelix)

88 - 106

TMHMM
TMhelix (TMhelix)

27 - 49

TMHMM
TMhelix (TMhelix)

303 - 325

TMHMM
TMhelix (TMhelix)

421 - 443

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

266 - 291

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

111 - 132

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

84 - 104

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

190 - 212

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

345 - 364

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

61 - 78

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

303 - 325

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

152 - 178

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

24 - 49

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

222 - 249

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

38F

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

41S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

42S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

43I

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

45L

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

46V

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

63M

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

66T

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

67L

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

70D

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

74S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

75Y

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

77L

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

78T

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

129I

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

130G

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

133K

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

134A

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

137E

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

138S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

141A

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

153Y

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

154A

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

157S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

158L

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

164A

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

278S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

281S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

282S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

286L

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

287S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

290S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

304L

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

308F

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

312G

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

315G

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

319M

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

366S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

369S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

370Q

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

373V

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

377Q

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

378A

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

381S

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

392V

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

393M

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

396V

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

397N

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

400K

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

401T

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

404Q

putative substrate translocation pore
38F, 41S, 42S, 43I, 45L, 46V, 63M, 66T, 67L, 70D, 74S, 75Y, 77L, 78T, 129I, 130G, 133K, 134A, 137E, 138S, 141A, 153Y, 154A, 157S, 158L, 164A, 278S, 281S, 282S, 286L, 287S, 290S, 304L, 308F, 312G, 315G, 319M, 366S, 369S, 370Q, 373V, 377Q, 378A, 381S, 392V, 393M, 396V, 397N, 400K, 401T, 404Q
CDD
cd06174 (MFS)

Protein sequence

>MIA_04177_1
MSGILTKFSQEIGLDLLFSSSRDVILLILIKIARMFAFGLSSIFLVQFFKVHGYPDDRTGIFMSCTLIGDVIISYFLTLN
ADRIGRRLVLCVGALLMVASGILFALSNNFYILLAAAVLGVISPSGADIGPFKAVEESTLAHLVPSDHRNDIYAWYSLAS
ALAAAGGNISGGWIVHYLMSPKIKLSELAAYKFIFVIFALLGALKFLFSLLLTQKVESEEHISSKSNAEPSENTSLLNPS
TTTASSPNTKKKFSLLPELSSDSFKIVIQLSFLFAMDSFGSSLVQLSWISYYITSKFHVNPEVLGTAFFITGFIGAFTML
ISSSISKRLGPVLTMALTHFPSSFLIIFIPMPSTFLVTFIILIIRSCTSQMDVAPRQAFLSMVVHSSERTAVMGWVNVVK
TCSQVFGPTIAGYLASLNKQWICFIIAGTLKVTYDALILLTFALKNVNREHA

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features