Protein

MIA_04085_1

Length
363 amino acids

Browser: contig05:710584-711676+

Protein function

EGGNOG:0PHVZNBP35Component of the cytosolic iron-sulfur (Fe S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins
SGD closest match:S000003059NBP35Cytosolic Fe-S cluster assembly factor NBP35

Protein alignments

%idAln lengthE-value
MCA_00004_180.547%3290.0MCA_00004_1
A0A0J9X4F5_GEOCN79.936%3140.0Cytosolic Fe-S cluster assembly factor NBP35 OS=Geotrichum candidum GN=NBP35 PE=3 SV=1
NBP35_YARLI72.671%3223.02e-173Cytosolic Fe-S cluster assembly factor NBP35 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=NBP35 PE=3 SV=1
UniRef50_Q6C7A672.671%3227.00e-170Cytosolic Fe-S cluster assembly factor NBP35 n=325 Tax=Eukaryota TaxID=2759 RepID=NBP35_YARLI
A0A060SXI8_BLAAD76.190%3152.11e-170Cytosolic Fe-S cluster assembly factor NBP35 OS=Blastobotrys adeninivorans GN=NBP35 PE=3 SV=1
A0A167DXZ9_9ASCO73.333%3152.50e-170Cytosolic Fe-S cluster assembly factor NBP35 OS=Sugiyamaella lignohabitans GN=NBP35 PE=3 SV=1
NBP35_CANAL74.769%3251.06e-169Cytosolic Fe-S cluster assembly factor NBP35 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NBP35 PE=3 SV=3
A0A1E4TIX9_9ASCO74.522%3141.25e-168Cytosolic Fe-S cluster assembly factor NBP35 OS=Tortispora caseinolytica NRRL Y-17796 GN=NBP35 PE=3 SV=1
A0A1E3PKQ2_9ASCO71.069%3183.70e-163Cytosolic Fe-S cluster assembly factor NBP35 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NBP35 PE=3 SV=1
NBP35_YEAST69.231%3122.79e-154Cytosolic Fe-S cluster assembly factor NBP35 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NBP35 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0228

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 363

Detailed signature matches

  1. Family IPR033756
    Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
    1. PF10609 (ParA)
  2. Family IPR019591
    Mrp/NBP35 ATP-binding protein
    1. MF_02040 (Mrp_NBP35)
    2. cd02037 (MRP-like)
  3. Family IPR028601
    Cytosolic Fe-S cluster assembly factor NUBP1/Nbp35
    1. MF_03038 (NUBP1)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. SITE IPR000808
    Mrp, conserved site
    1. PS01215 (MRP)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. mobidb-lite (disord...)

Residue annotation

  1. Walker A motif cd0...

Protein sequence

>MIA_04085_1
MTEVASNSQIQNIQAFAPIQGSELPLSTSVNDNQQSSQEKKPELTAPEPEHCPGTESELAGQADACQGCPNQEICASAPK
GPDPDLPLIRERVKDIEHKVLVLSGKGGVGKSTFTSMLGWAFAADESLEVGIMDVDVCGPSMPQMMGVQGERVHQSGEGW
TPVYVDDNLSVISIGFLLPDPDNAVIWRGPKKNGLIKQFLKDVVWGELDYLVVDTPPGTSDEHLSLNNYLKQENGESGVD
GAIIVTTPQEVALLDVRKEIDFCRKANIRILGIVENMSGFVCPNCKGESFIFAPTTGGGEALAKELNIPFLGKVPLDPRI
GKACDEGVNFLQEYPDSPACTAILDIIDKLRDEVENSLEEDQE

GO term prediction

Biological Process

GO:0016226 iron-sulfur cluster assembly

Molecular Function

GO:0005524 ATP binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding

Cellular Component

None predicted.