MIA_04040_1

Protein

Length

1,874 amino acids

Protein function

EGGNOG:	0PH75		rho guanyl nucleotide exchange factor

Protein alignments

	%id	Aln length	E-value
MCA_00038_1	43.621%	580	3.21e-125	MCA_00038_1
A0A0J9X5Z7_GEOCN	37.713%	586	8.05e-103	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA04s00747g PE=4 SV=1
UniRef50_A0A0J9X5Z7	37.713%	586	1.65e-99	Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5Z7_GEOCN
A0A060T2I9_BLAAD	31.099%	537	4.57e-57	ARAD1C32560p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C32560g PE=4 SV=1
A0A167D1G0_9ASCO	32.230%	453	1.22e-49	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_614 PE=4 SV=1
Q6C1S9_YARLI	38.863%	211	1.30e-33	YALI0F13673p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F13673g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0489

Protein family membership

None predicted.

Domains and repeats

Domain
1,001 - 1,226
Dbl homology (DH) domain (IPR000219)
1,394 - 1,546
Arfaptin homology (AH) domain/BAR domain (IPR027267)

1 200 400 600 800 1000 1200 1400 1600 1874

Detailed signature matches

IPR000219

Dbl homology (DH) domain
1. SSF48065 (DBL homol...)
  
  1,001 - 1,226
  
  SUPERFAMILY
  SSF48065 (DBL homology domain (DH-domain))
2. PF00621 (RhoGEF)
  
  1,022 - 1,223
  
  Pfam
  PF00621 (RhoGEF)
3. PS50010 (DH_2)
  
  1,018 - 1,225
  
  PROSITE profiles
  PS50010 (DH_2)
4. SM00325 (RhoGEF_3)
  
  1,022 - 1,224
  
  SMART
  SM00325 (RhoGEF_3)
IPR027267

Arfaptin homology (AH) domain/BAR domain
1. SSF103657 (BAR/IMD ...)
  
  1,394 - 1,546
  
  SUPERFAMILY
  SSF103657 (BAR/IMD domain-like)

no IPR

Unintegrated signatures

G3DSA:1.20.12...

1,285 - 1,548

GENE3D
G3DSA:1.20.1270.60 (G3DSA:1.20.1270.60)
G3DSA:1.20.90...

990 - 1,233

GENE3D
G3DSA:1.20.900.10 (G3DSA:1.20.900.10)
cd00160 (RhoGEF)

1,019 - 1,223

CDD
cd00160 (RhoGEF)
mobidb-lite (disord...)

1,781 - 1,857

MobiDB Lite
mobidb-lite (disorder_prediction)

767 - 799

MobiDB Lite
mobidb-lite (disorder_prediction)

1,634 - 1,663

MobiDB Lite
mobidb-lite (disorder_prediction)

1,676 - 1,755

MobiDB Lite
mobidb-lite (disorder_prediction)

574 - 651

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 92

MobiDB Lite
mobidb-lite (disorder_prediction)

459 - 508

MobiDB Lite
mobidb-lite (disorder_prediction)

889 - 923

MobiDB Lite
mobidb-lite (disorder_prediction)

811 - 837

MobiDB Lite
mobidb-lite (disorder_prediction)

1,238 - 1,272

MobiDB Lite
mobidb-lite (disorder_prediction)

232 - 330

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

GTPase interaction...

1,025E

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,029T

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,146N

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,174D

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,175S

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,178I

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,179K

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,181V

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,182Q

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,185L

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,186K

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,189L

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,190L

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,193S

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,219A

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

1,223N

GTPase interaction site
1,025E, 1,029T, 1,146N, 1,174D, 1,175S, 1,178I, 1,179K, 1,181V, 1,182Q, 1,185L, 1,186K, 1,189L, 1,190L, 1,193S, 1,219A, 1,223N
CDD
cd00160 (RhoGEF)

Protein sequence

>MIA_04040_1
MSLDEDNTRLKSASTASLSSTLSQRNKDLPPLPPSKSSSSRSKSSAVYRKASFNVPHDSKNLKGISRLNHSSPHILQRPP
SPASICSDDSDDSADSYVMTLSPNNPFMLFNAETHTPLLTTNHNIFETSHSNDGIAPPSPANFIIKSNQNSPSSRTLMHE
SQVFPESTINSCNLVPGFKDNTLRPINSTQGFQEEYIAPDEMITGNKTEFPLTSSIQPQITGYDFVESSYRKTSNSRSRS
GSGCIDSNSRNGSQSCQNLNSQPQDQLSFSVKTSTRKSNDQQIPSSASFSATPLDDIPTRPNKLQLQQPCSGSSKLNKTP
SKAKRSGNDISKLEASVASLPKPSAYTATVTPKKNVSLTEPVSLNSAVLAQPTLVSSSTTTPYTTPLFQNTSSISPPSSS
ALVIGPIDFAPNAISQKKNSFSSPVKFEDVLLTSSSLDSTMSQPIFIEAEVNLRRTSALRHKSKPATGITSHQTHSSLSL
NKSRAHQSSKLVTPEVKRNRRRSKSLDAFVNMTSVSSSSFRIRSSNATPPSASKASYTHLASPLTFQNTSSTSSSIKFSE
NLLNQEGDFISRRPSEINNENKSPSILPLNPNQSQSASLRVSQPMLLPDPLRETTKKSRRPSDTAKASGPTKEMSSPTPA
SARLPSTRHKPDALSLSDAVKLNFSSQVSEPRSPLTKLSKPKLSAASNSIFQASASSITTNSIGFVVPAVYDPKSNSDDF
ALSHNGNIIPVETFKKPLGDFNQKNSKKNQYSRNKSADDIFSNEFFKPDRDISQGSSSSPSTPTKSRHSLKRESHCSSNG
STNNFSYFSLESDSGSSTNNSTPRPNKCHRRSRSSSDFDTTWIERRKTLLGNSSLNSTVTSLDDNVNDRTDAWRLLDSNR
RLLENYPRSFSPVNAAPKSMKQSQKEYYSTKHKPSTDTSLTQPQSFQTYTDSAKNPSLYGFSDVNNSRTALNSSASSFIY
FSSTVTVNSQSNSSSLKQQKKLKLSKSAMNFNSKSATRTESLSTPIEPDQNIQKKLRTKYNCIRELISTEENFAKDLNIV
LSVYVKFAGLHPYSEYLDNRDLITLFGNISSVLSASQHFIKRLHRLVPSYIAEECRLDATDPENILKDVPSNVGMVFLDY
LPIMEKPFKEYCVKNKHQMNTFYRINKIACPTIDRWLVECNELSKPVTAAWSLDSLLIKPVQRLLKYPLLLSSILKNTPE
NHPDYLSLKHALKEIESCAQGINNEADSSSLISPVSIQHSFTDTPPSPESVTFSPDESPASSNSSTVSSVSPKQYILSSN
SPEYNSMLELLKDSNDADIELNNLLLQFEKKLTYVRDFMDSINDHVRNIQRHFDVTNNLAHHWMNWGALMDEDITNSALT
IDEPINTFSSPNDTLEATLKRSILSLKKYRRYSMFCSPFTTASSAHASTNRLKNRVDNEVLAPLYQVLSFFRKVKGLIDE
RTRLHVPFQKYLAQKDSHNNSLSTSTPFSSSSLSSSSSFSSASDNNPEVTLRRNADRFWLIHLKLKAELPALFNLSKKMS
ETCLIKFLAVQRDWFRNAVDSTSNAFQLRLEDIRQTSITGDPIVSSYLSKSETSVSKRIIEQELKICRKMKLHAMNTLKE
STSFSSLSSSGESTADDTRFDSFASNEDTFVDESFSHGSSRAVSPYKSAISSSQGETQLGMDTSFGSYEKSTVKPHSVSR
VIHKKASSHSFSRSYNGKSEETETDSTSESEETKHDISDQYLKPSFKGPTFTYNHPTHYIPKKARSHSQPHNNFSSTTAA
AIQSAVAATASCSLTPPALKTRTTSLSGVSSPSSKPNLPLQNSLSPAGAQSQTYPRFFNSTSTPTSTFPSDDFNDQLPFQ
DGQPRRHVRRKSSLGALSSLLPHKLMKNNYGTPN

GO term prediction

Biological Process

GO:0035023 regulation of Rho protein signal transduction

Molecular Function

GO:0005089 Rho guanyl-nucleotide exchange factor activity

Cellular Component