MIA_04032_1

Protein

Length

527 amino acids

Protein function

EGGNOG:	0PGCE	PGUG_00704	MFS phospholipid transporter (Git1)
SGD closest match:	S000000695	GIT1	Glycerophosphoinositol transporter 1
CGD closest match:	CAL0000176164	GIT4	Glycerophosphocholine permease GIT4

Protein alignments

	%id	Aln length	E-value
MCA_02247_1	84.38%	493	0.0	MCA_02247_1
A0A0J9XAM3_GEOCN	71.29%	533	0.0	Similar to Saccharomyces cerevisiae YCR098C GIT1 Plasma membrane permease OS=Geotrichum candidum GN=BN980_GECA07s02826g PE=4 SV=1
A0A167FR51_9ASCO	67.34%	493	0.0	Git1p OS=Sugiyamaella lignohabitans GN=GIT1 PE=4 SV=1
A0A060TAV5_BLAAD	66.60%	500	0.0	ARAD1B10384p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B10384g PE=4 SV=1
A0A1E3PGN2_9ASCO	63.64%	484	0.0	Phospholipid transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_27491 PE=4 SV=1
A0A1E4TJJ9_9ASCO	63.23%	465	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_23711 PE=4 SV=1
Q6CBN7_YARLI	55.43%	516	2e-179	YALI0C16929p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C16929g PE=4 SV=1
UniRef50_Q6CBN7	55.43%	516	4e-176	YALI0C16929p n=14 Tax=saccharomyceta TaxID=716545 RepID=Q6CBN7_YARLI
GIT4_CANAL	53.49%	516	8e-152	Glycerophosphocholine permease GIT4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GIT4 PE=1 SV=1
GIT1_YEAST	34.38%	477	5e-61	Glycerophosphoinositol transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIT1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0593

Protein family membership

Major facilitator, sugar transporter-like (IPR005828)

Domains and repeats

Domain
40 - 472
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 500 527

Detailed signature matches

IPR005828

Major facilitator, sugar transporter-like
1. PF00083 (Sugar_tr)
  
  253 - 473
  
  Pfam
  PF00083 (Sugar_tr)
  
  57 - 248
  
  Pfam
  PF00083 (Sugar_tr)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  50 - 466
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  40 - 472
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  51 - 461
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1 - 117

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

463 - 527

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

168 - 187

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

385 - 404

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

334 - 339

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

246 - 265

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

256 - 488

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

39 - 255

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

215 - 225

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

139 - 143

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

425 - 443

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

361 - 365

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

285 - 311

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

311 - 333

TMHMM
TMhelix (TMhelix)

191 - 213

TMHMM
TMhelix (TMhelix)

223 - 245

TMHMM
TMhelix (TMhelix)

406 - 428

TMHMM
TMhelix (TMhelix)

363 - 385

TMHMM
TMhelix (TMhelix)

443 - 465

TMHMM
TMhelix (TMhelix)

156 - 178

TMHMM
TMhelix (TMhelix)

340 - 359

TMHMM
TMhelix (TMhelix)

119 - 141

TMHMM
TMhelix (TMhelix)

274 - 296

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

118 - 138

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

312 - 333

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

444 - 462

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

366 - 384

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

144 - 167

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

188 - 214

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

226 - 245

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

405 - 424

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

340 - 360

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

266 - 284

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

68I

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

71V

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

72N

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

73T

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

75L

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

76G

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

93S

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

96A

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

97F

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

100T

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

104Q

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

105L

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

107F

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

108G

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

162I

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

163G

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

166Y

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

167P

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

170S

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

171V

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

174A

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

186N

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

187R

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

190V

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

191I

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

201F

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

285D

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

288A

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

289Y

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

293I

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

294Y

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

297A

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

311T

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

315N

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

319N

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

322Y

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

326A

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

379T

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

382E

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

383F

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

386G

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

390G

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

391I

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

394S

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

405Y

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

406Y

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

409A

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

410A

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

413G

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

414K

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

417A

putative substrate translocation pore
68I, 71V, 72N, 73T, 75L, 76G, 93S, 96A, 97F, 100T, 104Q, 105L, 107F, 108G, 162I, 163G, 166Y, 167P, 170S, 171V, 174A, 186N, 187R, 190V, 191I, 201F, 285D, 288A, 289Y, 293I, 294Y, 297A, 311T, 315N, 319N, 322Y, 326A, 379T, 382E, 383F, 386G, 390G, 391I, 394S, 405Y, 406Y, 409A, 410A, 413G, 414K, 417A
CDD
cd06174 (MFS)

Protein sequence

>MIA_04032_1
MSIISKWANMVAEETHLPWKHKQIIEENRERDETFLNSMEQKRGMKKYWPIITSGAGLFSDGYVNNSIGSVNTILGILYP
HEYKNSAAQSNVSSIAFVGTVVGQLSFGYVSDHYSRKIGMIVSTIILIVFTILGSGAWGAGGSIYGMLAALTAYRFFIGI
GIGGEYPAGSVAAAEASVLISRGSRNRWFVIFTNFMIDFGFVVSAFVPLVLLWICGINHLTPVWRITLGLGAIPPISLFF
LRLLYKENEQFTKNNMKRSGTPYWLATKYYFPRLFVVALIWFIYDFSAYSFGIYSSAIISIIIPDNDLYKTFGWNVVLNL
FYIPGAFLGAFASDYLGPRLSLVIGVGLQGIIGFIMAGIYEHLTHNIAGFVVMFGIFLTLGEFGPGDQIGIIASKTSATS
IRGQYYGIAAAVGKIGAFVGTKTFPYIIKRFGGSDTIRGNQGPFWISSGLCLFSALLALFFLPSLTQDSITEEDERFKAY
LEANGFDTSLMGEGDSNDSNDSMYDDAEKVIVCSDQKLEQSDKDKAF

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0022857 transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features