MIA_03961_1

Protein

Length

290 amino acids

Browser: contig05:361948-362887+

Protein function

EGGNOG:	0PH2U	FG01967.1	inositol monophosphatase
SGD closest match:	S000002695	INM2	Inositol monophosphatase 2

Protein alignments

	%id	Aln length	E-value
MCA_02227_1	77.320%	291	8.89e-169	MCA_02227_1
A0A060SYN8_BLAAD	63.514%	296	1.05e-141	Inositol-1-monophosphatase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A18436g PE=3 SV=1
A0A0J9XFD2_GEOCN	64.948%	291	2.86e-140	Inositol-1-monophosphatase OS=Geotrichum candidum GN=BN980_GECA13s02815g PE=3 SV=1
A0A161HJS4_9ASCO	64.706%	289	1.56e-139	Inositol-1-monophosphatase OS=Sugiyamaella lignohabitans GN=INM2 PE=3 SV=1
UniRef50_K0KT69	59.028%	288	3.76e-121	Inositol-1-monophosphatase n=79 Tax=Fungi TaxID=4751 RepID=K0KT69_WICCF
Q6CAB0_YARLI	56.376%	298	8.90e-123	Inositol-1-monophosphatase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D04378g PE=3 SV=2
INM2_YEAST	55.593%	295	7.29e-113	Inositol monophosphatase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=INM2 PE=1 SV=1
A0A1E4T9E6_9ASCO	58.596%	285	7.30e-112	Inositol-1-monophosphatase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148671 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1924

Protein family membership

Inositol monophosphatase-like (IPR000760)
- Inositol monophosphatase (IPR033942)

Domains and repeats

None predicted.

Detailed signature matches

IPR000760

Inositol monophosphatase-like
1. PR00377 (IMPHPHTASES)
  
  41 - 61
  
  PRINTS
  PR00377 (IMPHPHTASES)
  
  63 - 79
  
  PRINTS
  PR00377 (IMPHPHTASES)
  
  224 - 248
  
  PRINTS
  PR00377 (IMPHPHTASES)
  
  86 - 102
  
  PRINTS
  PR00377 (IMPHPHTASES)
  
  193 - 214
  
  PRINTS
  PR00377 (IMPHPHTASES)
2. PF00459 (Inositol_P)
  
  8 - 278
  
  Pfam
  PF00459 (Inositol_P)
IPR033942

Inositol monophosphatase
1. cd01639 (IMPase)
  
  11 - 264
  
  CDD
  cd01639 (IMPase)
IPR020583

Inositol monophosphatase, metal-binding site
1. PS00629 (IMP_1)
  
  86 - 99
  
  PROSITE patterns
  PS00629 (IMP_1)

no IPR

Unintegrated signatures

G3DSA:3.30.54...

1 - 149

GENE3D
G3DSA:3.30.540.10 (G3DSA:3.30.540.10)
G3DSA:3.40.19...

152 - 276

GENE3D
G3DSA:3.40.190.80 (G3DSA:3.40.190.80)
SSF56655 (Carbohydr...)

11 - 258

SUPERFAMILY
SSF56655 (Carbohydrate phosphatase)

Residue annotation

active site cd01639

36K

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

41D

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

47D

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

70E

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

71E

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

89D

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

90P

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

91I

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

92D

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

93G

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

94T

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

227W

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)

228D

active site
36K, 41D, 47D, 70E, 71E, 89D, 90P, 91I, 92D, 93G, 94T, 227W, 228D
CDD
cd01639 (IMPase)
dimerization inter...

40V

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

42L

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

95T

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

96N

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

98I

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

99H

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

100S

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

101Y

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

102P

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

103S

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

158S

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

159A

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

160L

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

162A

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

164E

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

165W

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

174F

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

175K

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

178T

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

181F

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

182K

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

185A

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

196H

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

197G

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

198F

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

199R

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

200S

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

201A

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

202G

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

210Y

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

214G

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

215Y

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

216I

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

217D

dimerization interface
40V, 42L, 95T, 96N, 98I, 99H, 100S, 101Y, 102P, 103S, 158S, 159A, 160L, 162A, 164E, 165W, 174F, 175K, 178T, 181F, 182K, 185A, 196H, 197G, 198F, 199R, 200S, 201A, 202G, 210Y, 214G, 215Y, 216I, 217D
CDD
cd01639 (IMPase)

Protein sequence

>MIA_03961_1
MTELNLELIKETLVALARQAGEVMKEKSGKTSFDDKANAVDLVTEIDKAVEELVHNALTAAFPDYKFLGEESYVPGKSEL
TDEPTFILDPIDGTTNFIHSYPSYCISLGFALNKKPTVGVVYNPVTNQLFSAIKGKGAYLNGTQKLPLTAPRPLKLQSAL
LAIEWGSDRAGNNFKVKTDTFKSLAADSKDGGAFAHGFRSAGSAALNISYAAAGYIDAYWEGGCWAWDVCAGWIILEEAN
GIMVGGNKGEWHPAVDSRLYFAVRGAEPDEQKKFVEDFWGHIQGTLDYKV

GO term prediction

Biological Process

GO:0046854 phosphatidylinositol phosphorylation
GO:0046855 inositol phosphate dephosphorylation

Molecular Function

GO:0008934 inositol monophosphate 1-phosphatase activity

Cellular Component