Protein

MIA_03783_1

Length
814 amino acids

Browser: contig04:2150393-2152979-

Protein function

EGGNOG:0PG13MRE11double-strand break repair protein
SGD closest match:S000004837MRE11Double-strand break repair protein MRE11
CGD closest match:CAL0000182868MRE11MRX complex nuclease subunit

Protein alignments

%idAln lengthE-value
A0A0J9XF95_GEOCN65.962%4730.0Similar to Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability OS=Geotrichum candidum GN=BN980_GECA13s02177g PE=3 SV=1
UniRef50_A0A0J9XF9565.962%4730.0Similar to Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XF95_GEOCN
A0A060TA40_BLAAD59.305%4890.0ARAD1D16258p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D16258g PE=3 SV=1
Q6CEM3_YARLI56.725%5130.0YALI0B14553p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B14553g PE=3 SV=1
MRE11_YEAST45.201%6462.63e-176Double-strand break repair protein MRE11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRE11 PE=1 SV=2
A0A1D8PQT2_CANAL48.521%5073.08e-175MRX complex nuclease subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MRE11 PE=3 SV=1
A0A1E3PLT3_9ASCO47.917%5281.53e-170DNA repair exonuclease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_77717 PE=3 SV=1
A0A1E4TB21_9ASCO50.372%4031.42e-139Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28330 PE=3 SV=1
A0A167E121_9ASCO46.050%4432.28e-126MRX complex nuclease subunit OS=Sugiyamaella lignohabitans GN=MRE11 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0815

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 814

Detailed signature matches

  1. Family IPR003701
    DNA double-strand break repair protein Mre11
    1. PIRSF000882 (DSB_re...)
    2. TIGR00583
  2. Domain IPR029052
    Metallo-dependent phosphatase-like
    1. SSF56300 (Metallo-d...)
    2. G3DSA:3.60.21.10
  3. Domain IPR004843
    Calcineurin-like phosphoesterase domain, ApaH type
    1. PF00149 (Metallophos)
  4. Domain IPR007281
    Mre11, DNA-binding
    1. PF04152 (Mre11_DNA_...)
    2. SM01347 (Mre11_DNA_...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. cd00840 (MPP_Mre11_N)
  3. mobidb-lite (disord...)

Residue annotation

  1. active site cd00840
  2. metal binding site...
  3. DNA binding site c...
  4. heterodimer interf...
  5. homodimer interfac...

Protein sequence

>MIA_03783_1
MPDDLPYDPDTIRILITTDNHVGYAENDPIRGNDAAVTFREIMNIAKNREVDMVLQAGDLFHVNKPSRKSMFEVITVLRE
TCYGDKPCELQLMSKVNLGLDDELNHLNYQDENINVAIPVFAISGNHDDAAGDSLLAPMDVLAATGLVNHFGRVQENDNI
SITPILLRKGETKLALYGMANVRDERLFRTFRHGQVKFFKPAKETGEWFNLMAVHQNHVAHSSTGYLPETFLPDFIDMVV
WGHEHDCISSPTKNPETGFSVLQPGSSVATSLIEGEAIPKYVFILSVTGKKFTLEKVRLMTVRPFAISSVSLAMDSGIDA
RISNRTEVTNWLHEQVELLISKAKEEWKSRPGNENLPEEDVPLPLIRLKVDYSGGYDVENPRRFSNRFVQRVANVNDVVS
FNRRRAVAMGGGHSQKRSSQNDLDNQKDNHQDINLEKIGVQNLVNEFLHSDDLLLLPETGLGDAVRRFVDNGDKDAIKTF
VDKSLELQLSTLMSIANLDEDSMSSEIVKAKKRLTRDTLQRSNDQTGATMAATSNTSVLNSVSANKNTIGTNDKGAKEVD
ATKAKPKRGRRTVNTTLTASKKAPTRNRRKAKSPETIEESDEDVIIENIEQGDNVMDLGDNDDEEVEDIPRTTSRSTKKN
TASTSRTTRAKKATTNTSVASSRTRQKSLRNAPVTSNNDESNDHDSDNDFEILEERSQGVSKSTYTPANALRAAQMASPV
KKALRNSTTMATVLRSARVTSGAHSGSNKSTGSRTIGAKRKRGEPAPPPPKVSSRQEDLVSSRKPFFLRFLIKFANGKTY
SYMTMRMTGSPELV

GO term prediction

Biological Process

GO:0006302 double-strand break repair

Molecular Function

GO:0004519 endonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding

Cellular Component

GO:0005634 nucleus
GO:0030870 Mre11 complex