Protein

MIA_03232_1

Length
371 amino acids

Browser: contig04:622481-623597-

Protein function

EGGNOG:0PKYJFG05284.13-hydroxyisobutyrate dehydrogenase
CGD closest match:CAL0000185703HPD1Hpd1p

Protein alignments

%idAln lengthE-value
MCA_00897_152.125%3531.33e-77MCA_00897_1
A0A1E4TCW6_9ASCO43.413%3344.05e-693-hydroxyisobutyrate dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_140437 PE=3 SV=1
UniRef50_A0A1E4TCW643.413%3341.42e-653-hydroxyisobutyrate dehydrogenase n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A1E4TCW6_9ASCO
A0A060TEJ0_BLAAD48.182%3301.65e-68ARAD1D08030p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D08030g PE=4 SV=1
Q6C351_YARLI47.368%3421.06e-65YALI0F02607p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F02607g PE=4 SV=1
A0A1E3PH66_9ASCO42.183%3393.71e-64Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_14076 PE=4 SV=1
A0A167FYG2_9ASCO52.809%2672.14e-52Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_3507 PE=4 SV=1
A0A1D8PQ07_CANAL37.176%3473.18e-38Hpd1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HPD1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9984
Predicted cleavage: 27

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 371

Detailed signature matches

  1. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  2. Domain IPR006115
    6-phosphogluconate dehydrogenase, NADP-binding
    1. PF03446 (NAD_binding_2)
  3. Domain IPR008927
    6-phosphogluconate dehydrogenase C-terminal domain-like
    1. SSF48179 (6-phospho...)
  4. Domain IPR013328
    6-phosphogluconate dehydrogenase, domain 2
    1. G3DSA:1.10.10...
  5. Domain IPR029154
    3-hydroxyisobutyrate dehydrogenase, NAD-binding domain
    1. PF14833 (NAD_bindin...)
  6. SITE IPR002204
    3-hydroxyisobutyrate dehydrogenase-related, conserved site
    1. PS00895 (3_HYDROXYI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...

Protein sequence

>MIA_03232_1
MLSIARRRPCPPALSRILRSPVSSRPSSSSSPAYTLRYGFIGLGRMGLPMAKNLRANLPNPDSPLHVFDVSEAPVADLMA
AAPNVHKHASVADVAQHADVVITMLPAPQHVKAVYAEIAAALASKPADPPRQKIFIDSSTIDVSTSIQTSNLLRGLPTAV
DSSPHLFFDAPVSGGVVGATNATLTFMVGGVPQSLVKSSASSGPPAPADEPLAAAYASLVRPTLATMGKNLVPCGGPGLG
LAAKLANNYLLALTNIATAESFQLARALGLDLALYSQIVASATGRSWSSDVNNPVPGILPNAPASREYTNGFGLSLMKKD
LGLAIQAARDTNLPLLLADDAYRVYSQVEQDPDCANRDMSVIYKYIQDHQK

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0051287 NAD binding

Cellular Component

None predicted.