Protein

MIA_03176_1

Length
582 amino acids

Browser: contig04:450210-451959-

Protein function

EGGNOG:0PGTWMAE1Malic enzyme
SGD closest match:S000001512MAE1NAD-dependent malic enzyme, mitochondrial
CGD closest match:CAL0000197087MAE1Malate dehydrogenase (Oxaloacetate-decarboxylating)

Protein alignments

%idAln lengthE-value
MCA_03942_178.472%5760.0MCA_03942_1
A0A0J9XJR4_GEOCN71.454%5710.0Similar to Saccharomyces cerevisiae YKL029C MAE1 Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate OS=Geotrichum candidum GN=BN980_GECA24s01154g PE=4 SV=1
A0A1E3PII7_9ASCO62.587%5720.0Malic-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83588 PE=4 SV=1
Q6C5F0_YARLI61.672%5740.0YALI0E18634p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E18634g PE=4 SV=1
Q5A4M2_CANAL56.294%5720.0Malate dehydrogenase (Oxaloacetate-decarboxylating) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MAE1 PE=4 SV=1
MAOM_YEAST56.971%5810.0NAD-dependent malic enzyme, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAE1 PE=1 SV=1
UniRef50_P3601356.971%5810.0NAD-dependent malic enzyme, mitochondrial n=61 Tax=saccharomyceta TaxID=716545 RepID=MAOM_YEAST
A0A1E4TB55_9ASCO56.842%5700.0Malic enzyme OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32377 PE=3 SV=1
A0A060T848_BLAAD52.504%5790.0ARAD1D04114p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D04114g PE=4 SV=1
A0A167D2Q9_9ASCO65.072%2098.42e-82Malate dehydrogenase (Oxaloacetate-decarboxylating) OS=Sugiyamaella lignohabitans GN=MAE1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0438
Predicted cleavage: 15

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 582

Detailed signature matches

  1. Family IPR001891
    Malic oxidoreductase
    1. PR00072 (MALOXRDTASE)
    2. PIRSF000106 (ME)
  2. Domain IPR012301
    Malic enzyme, N-terminal domain
    1. PF00390 (malic)
    2. G3DSA:3.40.50...
    3. SM01274 (malic_2)
  3. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  4. Domain IPR012302
    Malic enzyme, NAD-binding
    1. PF03949 (Malic_M)
    2. SM00919 (Malic_M_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. SSF53223 (Aminoacid...)
  3. cd05312 (NAD_bind_1...)

Residue annotation

  1. NAD(P) binding sit...

Protein sequence

>MIA_03176_1
MVNKHAPHSQHTRLSVTGPVDCPYTGRDILNTPALNKGSAFSKQERDLFDLHGLLPVHINTLDDQVSRAYQQFLRNPTDL
AKNAFCTSLKDQNEVLYYKFLLQHIAETFGIIYTPTQGEAIENYSHEFRRPEGCFLDIDHPDQIEQRLALFGPPDDVDYI
VVTDGESILGIGDQGTGGIGISVAKLTLMTLCAGIHPDRVVPVVLDTGTDRQTLLDDPLYMGNRFRRIRGQAYDDFIETF
VQAVKKLFPKAVLHFEDFGVKNARRILHKYRDVLPCFNDDIQGTGAVTLSAITAALKTLNTPIVDTRILIFGAGSAGLGI
AEQITDHLVTKGLSYKEACSHIWLIDRFGLLTKDSKGVSEGQLPYLVDSDLAQGINTLSLVDIIANFHPHILIGTSTQPG
AFTEAAVKEMNKHVERPIIFPLSNPTRLHEAVPKDLLEWTQGSALVATGSPFPPVYNRIISENNNCFSFPGIGLGAVLSR
SSRITKNMIAASVDALSAISPILTDPNGGLLPNLHDIRTVSRTIAVAVIKQAVKDGVATVQNEKSPGTDEFIQIPEDDEA
LAIWVENQMWKPEYRPLHQVQE

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004470 malic enzyme activity
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0051287 NAD binding

Cellular Component

None predicted.