Protein

MIA_02935_1

Length
369 amino acids

Browser: contig03:2140320-2141430+

Protein function

EGGNOG:0PFUQRRD2PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2 ) by dissociating the inactive form from the complex (By similarity)
SGD closest match:S000006073RRD2Serine/threonine-protein phosphatase 2A activator 2
CGD closest match:CAL0000193039RRD2Serine/threonine-protein phosphatase 2A activator 2

Protein alignments

%idAln lengthE-value
MCA_06394_164.023%3537.86e-161MCA_06394_1
A0A0J9X6L3_GEOCN64.972%3543.17e-160Serine/threonine-protein phosphatase 2A activator OS=Geotrichum candidum GN=BN980_GECA03s07963g PE=3 SV=1
A0A060TCR3_BLAAD60.399%3515.10e-148Serine/threonine-protein phosphatase 2A activator OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D40810g PE=3 SV=1
PTPA2_YARLI57.627%3545.01e-138Serine/threonine-protein phosphatase 2A activator 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RRD2 PE=3 SV=2
A0A167C1W2_9ASCO57.027%3708.64e-138Serine/threonine-protein phosphatase 2A activator OS=Sugiyamaella lignohabitans GN=RRD2 PE=3 SV=1
PTPA2_CANAL53.719%3636.25e-136Serine/threonine-protein phosphatase 2A activator 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RRD2 PE=3 SV=1
UniRef50_M7P3A552.199%3412.60e-123Serine/threonine-protein phosphatase 2A activator n=5 Tax=Fungi TaxID=4751 RepID=M7P3A5_PNEMU
PTPA2_YEAST50.000%3621.81e-120Serine/threonine-protein phosphatase 2A activator 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRD2 PE=1 SV=1
A0A1E3PIY4_9ASCO53.988%3268.64e-117Serine/threonine-protein phosphatase 2A activator OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83227 PE=3 SV=1
A0A1E4TAD3_9ASCO54.294%3261.58e-114Serine/threonine-protein phosphatase 2A activator OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_127901 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0101
Predicted cleavage: 33

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

  1. Family IPR004327
    Phosphotyrosyl phosphatase activator, PTPA
    1. PIRSF016325 (PTPA)
    2. cd04087 (PTPA)
    3. PF03095 (PTPA)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF140984 (PTPA-like)
  2. mobidb-lite (disord...)

Residue annotation

  1. peptide-induced di...
  2. ATP binding site c...
  3. putative interacti...
  4. putative PP2A bind...
  5. peptide binding po...

Protein sequence

>MIA_02935_1
MTDSPPHHHQQAQSQQQQLPIRRILTAKDLEIFQESPTHELILGFISDLNAAVMGKPNDTTLAASPVIDALLAVLDTVEA
LVDTHPPADTVSSRFGKPEFRDFYDDLKSQAPTVLGQHFASVSADHIAEIAAYFCDSWGNRTRIDYGSGHELNFVSFLLC
LKQLQVIDMAGDVPAALVLRVFVRYVAVMRRVQTFYWLEPAGSHGVWGLDDYHFLPFLFGSAQLATHKHLRPSSIHDRDL
VDMYAPKYMYFDAIRFINSVKTVASLRWHSPMLDDISGVKKWSKVNEGMLKMYKAEVLGKLPIMQHYMFGTLIQAPEGVS
PPPAPGAEEAPHVHNHWADCCGIKVPSAIAASAMEKKEDHFRSALIPFD

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0019211 phosphatase activator activity

Cellular Component

None predicted.