Protein

MIA_02923_1

Length
641 amino acids

Browser: contig03:2093029-2094955-

Protein function

EGGNOG:0PFJ7FG06358.1Translation initiation factor eIF-2B
SGD closest match:S000002619GCD6Translation initiation factor eIF-2B subunit epsilon
CGD closest match:CAL0000183518GCD6Translation initiation factor eIF-2B subunit epsilon

Protein alignments

%idAln lengthE-value
MCA_04108_161.282%3901.26e-165MCA_04108_1
A0A0J9XCA6_GEOCN58.779%3936.96e-156Similar to Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B OS=Geotrichum candidum GN=BN980_GECA09s00197g PE=4 SV=1
UniRef50_A0A0J9XCA658.779%3931.42e-152Similar to Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XCA6_GEOCN
A0A060T3E2_BLAAD58.311%3798.81e-147ARAD1C32384p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C32384g PE=4 SV=1
A0A1E3PHM6_9ASCO54.813%3741.69e-135Translation initiation factor eIF-2B epsilon subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51468 PE=4 SV=1
Q6CEG9_YARLI52.926%3934.98e-134YALI0B15708p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B15708g PE=4 SV=1
A0A167DXF9_9ASCO55.014%3494.09e-120Gcd6p OS=Sugiyamaella lignohabitans GN=GCD6 PE=4 SV=1
EI2BE_CANAL47.015%4026.69e-118Translation initiation factor eIF-2B subunit epsilon OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GCD6 PE=3 SV=3
EI2BE_YEAST46.447%3941.61e-113Translation initiation factor eIF-2B subunit epsilon OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCD6 PE=1 SV=1
A0A1E4THH7_9ASCO47.668%3863.59e-106Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15132 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0144

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Repeat
1 100 200 300 400 500 641

Detailed signature matches

  1. Domain IPR029044
    Nucleotide-diphospho-sugar transferases
    1. G3DSA:3.90.55...
    2. SSF53448 (Nucleotid...)
  2. Domain IPR005835
    Nucleotidyl transferase domain
    1. PF00483 (NTP_transf...)
  3. Domain IPR035543
    Translation initiation factor eIF-2B subunit epsilon, N-terminal
    1. cd04197 (eIF-2B_eps...)
  4. Domain IPR011004
    Trimeric LpxA-like
    1. SSF51161 (Trimeric ...)
  5. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  6. Domain IPR003307
    W2 domain
    1. PS51363 (W2)
  7. Repeat IPR001451
    Hexapeptide repeat
    1. PF00132 (Hexapep)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.25.40...
  2. G3DSA:2.160.1...
  3. cd11558 (W2_eIF2B_e...)
  4. mobidb-lite (disord...)

Residue annotation

  1. putative essential...

Protein sequence

>MIA_02923_1
MAPPKKKSANKNEAQNEGLQAIVLSDSYQDRFLPLTRERPRCLLPLANTPLLEYTLEFLATARVTEVFVIASSHAKQIEQ
YVQGSRWMAASAPFRVEVIESESSSIGDALRDIDRLGLVTRDFLLISGDIVSNIDFSKVLEAHRARADRNAIMTMVLRQA
AANHRTRARDGAGLFVIAEPSGQCVRYEQAPEPQQERLGAVEIDWEAVGGFETLSLRNDLIDCHIDICTPDVPALFTENF
DYNELRTDFVRGIVTSELLGKTIYTYLVDGEYSARVESYQTYDAVSRDVIARYAYPLTPEYNLLEDQRFRHHSGHIYKEE
GGVVLAQSCVVGPESVIGAGTVIGEGSVVGQSVVGRRCVIGSGVELEGAYLWAGVTVEDGARVERAVVASGAVIRSGVRV
GGGAVVLFGEEVTADRFGAPDDMDSLVYEVGRIELSDEEGWIDGEDEDGVKRGGSGKEKKSRRGTKGKDVEEDDDEDDDF
HSEAIASIERAITENHDMDIAVLELNTLRMTLNVGYEQVRAATAAALVRYVEKLVRTGTLKLKAAVERVFGRWGGLFRRQ
AFEGADEEDVLRAVAREFAQGGGSKWQAGVVYAMESLYDVEAVGEDACVGFHGALARAGGDAVLVGLVGRFVEWLESAES
E

GO term prediction

Biological Process

GO:0009058 biosynthetic process

Molecular Function

GO:0005488 binding
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity

Cellular Component

None predicted.