Protein

MIA_02896_1

Length
1,757 amino acids

Browser: contig03:2036704-2042028-

Protein function

EGGNOG:0PI2RUBP12ubiquitin carboxyl-terminal hydrolase
SGD closest match:S000003733UBP12Ubiquitin carboxyl-terminal hydrolase 12
CGD closest match:CAL0000197778orf19.6260Putative ubiquitin-specific protease

Protein alignments

%idAln lengthE-value
MCA_02727_150.909%4409.33e-135MCA_02727_1
A0A0J9XA09_GEOCN48.157%4073.67e-109Similar to Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin carboxyl-terminal hydrolase OS=Geotrichum candidum GN=BN980_GECA05s04509g PE=3 SV=1
UniRef50_A0A0J9XA0948.157%4077.50e-106Similar to Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin carboxyl-terminal hydrolase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XA09_GEOCN
A0A060T8Z8_BLAAD45.430%3722.98e-92ARAD1D11484p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D11484g PE=3 SV=1
Q6CEM1_YARLI50.534%2811.04e-80YALI0B14597p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B14597g PE=3 SV=1
UBP12_YEAST40.214%3731.00e-74Ubiquitin carboxyl-terminal hydrolase 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP12 PE=1 SV=1
A0A1E3PJ34_9ASCO50.175%2851.04e-81Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_6315 PE=4 SV=1
A0A1D8PDT6_CANAL48.669%2633.07e-71Putative ubiquitin-specific protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6260 PE=3 SV=1
A0A1E4TDS1_9ASCO57.143%1963.09e-69Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_17713 PE=4 SV=1
A0A161HJ96_9ASCO51.000%2001.03e-57Ubp12p OS=Sugiyamaella lignohabitans GN=UBP12 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0046

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1400 1600 1757

Detailed signature matches

  1. Domain IPR006615
    Peptidase C19, ubiquitin-specific peptidase, DUSP domain
    1. PS51283 (DUSP)
    2. SSF143791 (DUSP-like)
    3. G3DSA:3.30.22...
  2. Domain IPR028889
    Ubiquitin specific protease domain
    1. PS50235 (USP_3)
  3. Domain IPR001394
    Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    1. PF00443 (UCH)
  4. SITE IPR018200
    Ubiquitin specific protease, conserved site
    1. PS00972 (USP_1)
    2. PS00973 (USP_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.90.70.10
  3. SSF54001 (Cysteine ...)
  4. cd02674 (Peptidase_...)
  5. mobidb-lite (disord...)

Residue annotation

  1. Active Site cd02674

Protein sequence

>MIA_02896_1
MIPAEKSPTEPIHHDISSHISVQPASNVNFSSDSLPKVDFSSPEETSDPISSANSSCNSSNNTTDISNSAYPQVKTPIKF
TEAETDIAMDDEEENISNISPNSQSSSVGISSRNKRLVSDMDFSPRPQSNASTGAAFQQSSTGVSTRIRPNDQQTPHSHL
NSTISSAMPPVSEKLSDDEDISMPYDELEIDLSNDPIKIVSRKERVSYIKHQSASIRPAVGDVLYLVSAAWVESFANFST
DDFAETFGNLDIVNHSSRQLFSAELSKYLPLPKPAWDNLVKWYRPEGKDGFDYFSLPRKVTGIEPLQFDYFPLTVYTKIF
TRISLSISPNTKIVISESSLGSDFYYTVFQLYSLPSNTLFEQIRIWGVVNTPDTLRIMKQDTPLAQLPFKAMSSNLHAID
LDSNKKISDSNLNMFSFIIIEFKEINDKASPWPSEQIKPPLPPRRNLPPPYTLDVPKNDSISEKTKQEDNDEDEDDEEVD
SEEEDEDEDDDNKKVSENPVTAPPPPPPSRPKNAQTYSYRNTYTVPIGTMGLNNLGNTCYMNSALQCLTHVPELVNYFLS
GYFKREINRTNPIGYNGKIAEAFGDLLMHLFGEERSGSSYACRPFKTTVGRLNSAFAGYQQQDTQEFLSYLLDGLHEDLN
RVLKKPLTEKPDLKKHGSHSPEEIAELAEECWRLHKLRNDSVILDLFVGLYKSTLVCPTCHLTSITFDPFMDLTLPLPSN
EYWCKDMLVFPKNGRPIRLAVELDPSATMCHLRKFIADNTGVDPRALHFADILDKHIYKNIKDGNVNDQITSYDTIYVYE
ADAPLDRDSKINEEEKVQKDQEEEVEETEKEEEDDIHFVIPVYLFISSEGQSRKAPFPYYITLTKSDAENPSIIIQKILT
KLAQYSNSELFDVAIDQISSGSLSWKSVIDVFTPHICYNSKYNRDIPYTGEPTDTRCTFLERVEEISTNVSLGARMLEQQ
KQEEERQRQEYANYNNYQQTNIQPDNDSLGDGLPAYEEAVNDFAGDDYTSQFTKNSPPDLPNRDDYSPIENSNTNDELSS
NQADNGEESESSFDGNSDSVSRLPANSSSSNLQYADRMTPEDSIINSDPTSSYDEDITFSKSKNFQSSSYKGGLPGGNGN
DEEFEKTPSEESAQENGDFDALNLSTLPDSDTSSASSLSFSGPLENSNANNHAVTIVNGDHASGDDHYGSSFSPPSPISS
RKNYHNAPRYQPSRIHRNYQNNKYGYSNIYSRFSPRVPDFIRDAYFDPDNKLIVSPSALIAIEIEQSRYDSLFDETNLPS
LFIDIVSPDIIKRRAAREAMRVKGATLDDCLDQFYKTEVLGEDDLWYCTNCQGFKRASKTLELWKTPDVFIIHLKRFSSW
REKINDTIKFPITGLDMSRRIIETKTNSKFLETPPKTIPIDEEDKSLMYDLFAVDNHFGSVHGGHYTAYVKNFADNKWYY
FDDSRVTEANPEEAISGSAYLLFYRRRGSSPLGGEHMNEIFTTIEAEREANTDSNSSLDAHVDSTEDDKRLLAKRFPGVG
RSLGGGSGSLGSSVVSNFGSSLCGTGSEFSSTSELPSSAEEGTHMVSNTQFESDFIGDGSGNSSSSSSINSSVSNDNVRG
AVDGHQDSLNKTSFSGELGPAATSTRNVSRDRRGSNSRIIGDSSPKDVKALAKIDINTENPTSHDVELDLEENNIDEDGD
DNNSLYDDAGFQNLVDGYHSTRRLERPPVMAIEVLKPDQLLPKASAGSQEVSQGLKQSTEESLDYAKHSLPSPASED

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Cellular Component

None predicted.