Protein

MIA_02858_1

Length
492 amino acids

Browser: contig03:1937527-1939073+

Protein function

EGGNOG:0PF9GFG01111.1Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
SGD closest match:S000001226GND16-phosphogluconate dehydrogenase, decarboxylating 1
CGD closest match:CAL0000188008GND16-phosphogluconate dehydrogenase, decarboxylating

Protein alignments

%idAln lengthE-value
MCA_04168_183.640%4890.0MCA_04168_1
A0A0J9XAB6_GEOCN80.816%4900.06-phosphogluconate dehydrogenase, decarboxylating OS=Geotrichum candidum GN=BN980_GECA07s00637g PE=3 SV=1
A0A060T803_BLAAD77.618%4870.06-phosphogluconate dehydrogenase, decarboxylating OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D06666g PE=3 SV=1
A0A1E3PKU6_9ASCO75.714%4900.06-phosphogluconate dehydrogenase, decarboxylating OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_70290 PE=3 SV=1
A0A170QZV3_9ASCO77.941%4760.06-phosphogluconate dehydrogenase, decarboxylating OS=Sugiyamaella lignohabitans GN=GND2 PE=3 SV=1
A0A1E4TBC4_9ASCO73.868%4860.06-phosphogluconate dehydrogenase, decarboxylating OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_133361 PE=3 SV=1
Q6CEH4_YARLI73.171%4920.06-phosphogluconate dehydrogenase, decarboxylating OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B15598g PE=3 SV=1
UniRef50_A0A1S9RJI972.597%4890.06-phosphogluconate dehydrogenase, decarboxylating n=2 Tax=Aspergillaceae TaxID=1131492 RepID=A0A1S9RJI9_9EURO
A0A1D8PFS4_CANAL71.717%4950.06-phosphogluconate dehydrogenase, decarboxylating OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GND1 PE=3 SV=1
6PGD1_YEAST70.902%4880.06-phosphogluconate dehydrogenase, decarboxylating 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GND1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0073

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 492

Detailed signature matches

  1. Family IPR006183
    6-phosphogluconate dehydrogenase
    1. PR00076 (6PGDHDRGNASE)
  2. Family IPR006113
    6-phosphogluconate dehydrogenase, decarboxylating
    1. TIGR00873
    2. PIRSF000109 (6PGD)
  3. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  4. Domain IPR006115
    6-phosphogluconate dehydrogenase, NADP-binding
    1. PF03446 (NAD_binding_2)
  5. Domain IPR008927
    6-phosphogluconate dehydrogenase C-terminal domain-like
    1. SSF48179 (6-phospho...)
  6. Domain IPR006114
    6-phosphogluconate dehydrogenase, C-terminal
    1. PF00393 (6PGD)
    2. SM01350 (6PGD_2)
  7. Domain IPR013328
    6-phosphogluconate dehydrogenase, domain 2
    1. G3DSA:1.10.10...
  8. SITE IPR006184
    6-phosphogluconate-binding site
    1. PS00461 (6PGD)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.20.5.320
  2. G3DSA:3.40.50...

Protein sequence

>MIA_02858_1
MSTEPRGDIGLIGLAVMGQNLVLNAADHGYEVVVFNRTVSKVDHFLANEAKGKSIIGAHSIEELVKNLKRPRRIILLVKA
GQAVDDFIALLEPHLEKGDIIIDGGNSHFPDTIRRYEELKSRGLLFVGSGVSGGEEGARHGPSLMPGGHPDAWPHIKAIF
QDIAAKTDGEPCCDWVGPSGSGHFVKMVHNGIEYGDMQLIAEAYDILKRGLGLSDKEMGDVFAKWNKGVLDSYLIEITRD
ILYFKDEDDGTPLVEKILDAAGQKGTGKWTVSTALDYGVPVTLIGEAVFSRTLSSIKDERVRASKILTGPTPAFSGDKQK
FIDDLEQALYASKIISYTQGFMLIREAGKVHDWEFNNAGLGLMWRGGCIIRSVFLGDITKAYQKNPKLESLLFDDFFHAA
IDKAQPSWRRIIGLGAELGIPTPAFATALAWYDGYRSNRLPANLIQAQRDYFGAHTYKVLDEFVSQKYPKEGGIHTNWTG
RGGNISASTYNA

GO term prediction

Biological Process

GO:0006098 pentose-phosphate shunt
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.