MIA_02830_1

Protein

Length

525 amino acids

Protein function

EGGNOG:	0PGTQ		aminotriazole resistance protein
SGD closest match:	S000005905	YOR378W	Drug resistance protein YOR378W
CGD closest match:	CAL0000192014	orf19.2350	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_03550_1	54.667%	525	0.0	MCA_03550_1
Q59WF2_CANAL	43.945%	512	1.64e-138	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2350 PE=4 SV=1
UniRef50_Q59WF2	43.945%	512	3.97e-135	Uncharacterized protein n=21 Tax=Saccharomycetales TaxID=4892 RepID=Q59WF2_CANAL
YO378_YEAST	46.497%	471	4.72e-130	Drug resistance protein YOR378W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YOR378W PE=1 SV=1
A0A060T9P2_BLAAD	43.606%	477	1.22e-122	ARAD1D20108p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20108g PE=4 SV=1
A0A167C1I5_9ASCO	40.307%	521	5.19e-115	Amf1p OS=Sugiyamaella lignohabitans GN=AMF1 PE=4 SV=1
A0A1E3PEI3_9ASCO	29.904%	418	1.39e-47	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_71964 PE=4 SV=1
A0A0J9XHK3_GEOCN	29.569%	487	1.62e-40	Similar to Saccharomyces cerevisiae YOR378W Putative paralog of ATR1, member of the DHA2 family of drug:H+ antiporters OS=Geotrichum candidum GN=BN980_GECA18s01737g PE=4 SV=1
Q6C2L1_YARLI	26.721%	494	6.57e-37	YALI0F06908p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F06908g PE=4 SV=1
A0A1E4TJU9_9ASCO	29.844%	449	3.85e-34	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_80956 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0071

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
55 - 521
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 500 525

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  67 - 467
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  55 - 519
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  62 - 255
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  306 - 521
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  64 - 474
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

383 - 388

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

119 - 129

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

184 - 189

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 60

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

440 - 450

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

246 - 256

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

307 - 326

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

513 - 525

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

54 - 256

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

324 - 525

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

151 - 161

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

212 - 222

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

408 - 412

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

473 - 491

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

277 - 287

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

89 - 99

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

346 - 359

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

494 - 516

TMHMM
TMhelix (TMhelix)

100 - 122

TMHMM
TMhelix (TMhelix)

389 - 408

TMHMM
TMhelix (TMhelix)

63 - 85

TMHMM
TMhelix (TMhelix)

360 - 382

TMHMM
TMhelix (TMhelix)

224 - 246

TMHMM
TMhelix (TMhelix)

259 - 276

TMHMM
TMhelix (TMhelix)

192 - 214

TMHMM
TMhelix (TMhelix)

418 - 440

TMHMM
TMhelix (TMhelix)

286 - 305

TMHMM
TMhelix (TMhelix)

452 - 474

TMHMM
TMhelix (TMhelix)

166 - 185

TMHMM
TMhelix (TMhelix)

129 - 151

TMHMM
TMhelix (TMhelix)

326 - 345

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

223 - 245

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

413 - 439

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

61 - 88

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

190 - 211

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

492 - 512

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

288 - 306

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

130 - 150

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

389 - 407

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

162 - 183

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

360 - 382

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

327 - 345

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

100 - 118

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

257 - 276

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

451 - 472

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

78V

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

81T

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

82I

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

83V

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

85Y

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

86R

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

104S

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

107Y

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

108S

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

111V

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

115I

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

116L

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

118A

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

119G

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

168P

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

169A

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

172N

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

173P

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

176A

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

177G

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

180G

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

193M

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

194C

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

197G

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

198G

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

204F

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

335W

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

338F

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

339G

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

342I

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

343Y

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

346H

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

360M

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

364L

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

368C

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

371G

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

375S

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

426P

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

429M

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

430D

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

433F

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

437T

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

438V

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

441S

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

452A

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

453G

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

456V

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

457S

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

460V

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

461N

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

464I

putative substrate translocation pore
78V, 81T, 82I, 83V, 85Y, 86R, 104S, 107Y, 108S, 111V, 115I, 116L, 118A, 119G, 168P, 169A, 172N, 173P, 176A, 177G, 180G, 193M, 194C, 197G, 198G, 204F, 335W, 338F, 339G, 342I, 343Y, 346H, 360M, 364L, 368C, 371G, 375S, 426P, 429M, 430D, 433F, 437T, 438V, 441S, 452A, 453G, 456V, 457S, 460V, 461N, 464I
CDD
cd06174 (MFS)

Protein sequence

>MIA_02830_1
MNEKEYSECITTFQADSGKDEYTRDIEAEENDCNLTHSTSHIDGTTDPVPPYDQIALLHEIAFVFVIISAQIFTQASVAQ
TIVAYRSIGKTFGVSSIGELSWYSSAYSLTVGTFILIAGRLGDMYGLKRIYIAGMLWMALWSLVCGLAHYSKSSIFFSVC
RALQGIGPAFINPIAAGIFGSYYPVGSRRVLVMCLFGGIGPTGFTMGSLFSGLITQLGGSWPWFFYAESIACAVFAGLSY
IFIPANIGHVWTTKQTFDYLGAITGVCGLVLFNFAWNQGPVVGWDTPYVYILLIVSVLILALFLYVEHRVENPLLPPETF
RGDVGTLLGCIAAGWSCFGIWIYYVHRFGYELEHRTMLNMTARLCMICIGGVYASLFCAFLIPRIKSSWIMLISMFGYFF
GNLLTVLRPVNQIFWAQMFVSLLLIPFGMDMSFPAATVILSQNLPKEKQGVAGSVVSTVVNYSISIGLGIAATVEYYSEK
NGHSEEQVIRNAQWTGTGLGGLGVLIAAVFVFKQVFWTKKQKENM

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features