MIA_02412_1

Protein

Length

521 amino acids

Protein function

EGGNOG:	0PFT2	FG04217.1	transporter
SGD closest match:	S000003492	TNA1	High-affinity nicotinic acid transporter
CGD closest match:	CAL0000180798	TNA1	Tna1p

Protein alignments

	%id	Aln length	E-value
A0A0J9X8G3_GEOCN	72.070%	512	0.0	Similar to Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease OS=Geotrichum candidum GN=BN980_GECA05s02397g PE=4 SV=1
MCA_01596_1	72.169%	521	0.0	MCA_01596_1
A0A060T589_BLAAD	62.402%	508	0.0	ARAD1B08778p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08778g PE=4 SV=1
Q6C9M0_YARLI	62.146%	494	0.0	YALI0D10043p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D10043g PE=4 SV=1
A0A1E3PQS9_9ASCO	63.057%	471	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69122 PE=4 SV=1
A0A167D5S6_9ASCO	61.454%	454	0.0	Tna1p OS=Sugiyamaella lignohabitans GN=TNA1 PE=4 SV=1
UniRef50_A0A167D5S6	61.454%	454	0.0	Tna1p n=9 Tax=Saccharomycetales TaxID=4892 RepID=A0A167D5S6_9ASCO
A0A1E4TJC7_9ASCO	51.992%	477	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_78029 PE=4 SV=1
A0A1D8PNL8_CANAL	50.924%	487	5.63e-164	Tna1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TNA1 PE=4 SV=1
TNA1_YEAST	29.094%	519	1.08e-73	High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TNA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0843

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
62 - 490
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 521

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  79 - 446
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  75 - 490
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  62 - 485
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  76 - 480
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1 - 74

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

190 - 200

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

421 - 431

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

257 - 304

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

363 - 368

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

135 - 140

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

482 - 521

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

63 - 272

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

295 - 498

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

160 - 170

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

224 - 234

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

326 - 344

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

389 - 399

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

94 - 112

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

453 - 457

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

201 - 223

TMHMM
TMhelix (TMhelix)

233 - 255

TMHMM
TMhelix (TMhelix)

166 - 188

TMHMM
TMhelix (TMhelix)

141 - 160

TMHMM
TMhelix (TMhelix)

112 - 134

TMHMM
TMhelix (TMhelix)

430 - 452

TMHMM
TMhelix (TMhelix)

462 - 484

TMHMM
TMhelix (TMhelix)

369 - 388

TMHMM
TMhelix (TMhelix)

73 - 92

TMHMM
TMhelix (TMhelix)

340 - 362

TMHMM
TMhelix (TMhelix)

308 - 330

TMHMM
TMhelix (TMhelix)

398 - 417

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

171 - 189

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

201 - 223

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

75 - 93

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

141 - 159

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

345 - 362

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

113 - 134

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

235 - 256

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

400 - 420

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

432 - 452

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

305 - 325

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

458 - 481

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

369 - 388

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 21

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

90R

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

93I

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

94S

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

95N

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

97N

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

98V

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

116L

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

119F

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

120F

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

123Y

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

127E

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

128I

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

130S

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

131N

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

177E

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

178A

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

181F

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

182P

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

185F

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

186Y

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

189S

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

201Y

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

202S

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

205F

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

206S

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

212G

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

316I

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

319A

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

320Y

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

323A

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

324Y

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

327A

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

340T

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

344S

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

348W

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

351A

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

355S

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

403A

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

406G

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

407L

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

410A

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

414L

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

415V

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

420M

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

431S

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

432T

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

435Q

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

436V

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

439G

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

440N

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

443G

putative substrate translocation pore
90R, 93I, 94S, 95N, 97N, 98V, 116L, 119F, 120F, 123Y, 127E, 128I, 130S, 131N, 177E, 178A, 181F, 182P, 185F, 186Y, 189S, 201Y, 202S, 205F, 206S, 212G, 316I, 319A, 320Y, 323A, 324Y, 327A, 340T, 344S, 348W, 351A, 355S, 403A, 406G, 407L, 410A, 414L, 415V, 420M, 431S, 432T, 435Q, 436V, 439G, 440N, 443G
CDD
cd06174 (MFS)

Protein sequence

>MIA_02412_1
MTDQNTNAQQNLEKDSASHTSSINEITEEKLEAQETCTGPEQILTPEEQKIRISKLAEKYGINERKLMLKCDLRIVPAIC
LLYLLAFLDRVNISNANVYGLASDLNLRGHQYNTALTIFFVPYIVSEIPSNYLLKKFKPHVWLCLCMVLFGCVTIAQGFV
QNFGGLVVTRFFLGLCEAGMFPGCFYLLSMWYRREEAQKRYSFFFSSTCLAGAFSGLIAAGIWRLDGKRGLEGWRWIFII
EGAVTVFCALIMFFCVSDFPEDASYLKENERLFIKEKLALDVGDSTHDVKITFKGILHVFKEWKIWFSGLMYFCLIIPAY
GYAYFAATIVKSLGHSPLKTQFYSVPPWVVAFGLSMIMAVFSDRLRHRFTFSFICCLIAASGFIMLLANKTNVHVRYGGL
FLAASGLYTAMPILVCWTNMNFSGHHRKAISTAWQVSFGNIGGIIATFSFLAKDAPHYVKGVSIGLAFSLLAGILMIFYL
LGLIHDNRKKRTPEAIAKWEAFSPEERRAGGDLSPYFFYDY

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features