MIA_02319_1

Protein

Length

516 amino acids

Protein function

EGGNOG:	0QDJA		Allantoate
SGD closest match:	S000003994	THI73	Thiamine pathway transporter THI73
CGD closest match:	CAL0000177200	DAL8	Dal8p

Protein alignments

	%id	Aln length	E-value
MCA_04148_1	71.760%	517	0.0	MCA_04148_1
A0A060SY94_BLAAD	58.546%	509	0.0	ARAD1A19030p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A19030g PE=4 SV=1
UniRef50_B6HUY9	56.226%	514	4.87e-177	Pc22g14520 protein n=143 Tax=Fungi TaxID=4751 RepID=B6HUY9_PENRW
A0A1E3PG96_9ASCO	33.652%	523	2.59e-91	Allantoin permease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47618 PE=4 SV=1
Q6CA52_YARLI	34.055%	508	4.06e-90	YALI0D05819p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D05819g PE=4 SV=1
Q5ANP1_CANAL	34.316%	475	5.51e-89	Dal8p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DAL8 PE=4 SV=1
A0A167CPW8_9ASCO	33.024%	539	5.52e-88	Thi73p OS=Sugiyamaella lignohabitans GN=THI73 PE=4 SV=1
THI73_YEAST	33.401%	494	1.88e-78	Thiamine pathway transporter THI73 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI73 PE=1 SV=1
A0A1E4THX6_9ASCO	28.509%	456	1.21e-48	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148212 PE=4 SV=1
A0A0J9X623_GEOCN	25.631%	515	2.02e-43	Similar to Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease OS=Geotrichum candidum GN=BN980_GECA02s07710g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0144

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
46 - 489
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 516

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  73 - 443
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  69 - 488
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  46 - 489
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  70 - 445
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

354 - 364

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

186 - 196

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 64

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

480 - 516

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

249 - 289

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

130 - 135

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

415 - 425

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

57 - 265

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

286 - 495

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

386 - 396

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

447 - 457

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

154 - 164

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

310 - 328

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

217 - 227

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

83 - 105

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

160 - 182

TMHMM
TMhelix (TMhelix)

397 - 419

TMHMM
TMhelix (TMhelix)

365 - 387

TMHMM
TMhelix (TMhelix)

298 - 320

TMHMM
TMhelix (TMhelix)

107 - 129

TMHMM
TMhelix (TMhelix)

330 - 352

TMHMM
TMhelix (TMhelix)

195 - 217

TMHMM
TMhelix (TMhelix)

426 - 447

TMHMM
TMhelix (TMhelix)

136 - 155

TMHMM
TMhelix (TMhelix)

70 - 92

TMHMM
TMhelix (TMhelix)

457 - 479

TMHMM
TMhelix (TMhelix)

230 - 249

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

397 - 414

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

106 - 129

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

228 - 248

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

136 - 153

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

65 - 82

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

197 - 216

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

290 - 309

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

458 - 479

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

426 - 446

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

365 - 385

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

165 - 185

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

329 - 353

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

84K

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

87L

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

88S

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

89Y

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

91A

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

92I

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

110S

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

113F

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

114Y

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

117F

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

121S

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

122V

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

124T

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

125N

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

171E

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

172C

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

175D

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

176P

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

179M

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

180L

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

183G

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

195I

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

196G

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

199F

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

200S

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

206V

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

307N

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

310N

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

311G

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

314S

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

315N

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

318T

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

331T

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

335S

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

339G

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

342I

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

346I

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

401G

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

404Y

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

405A

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

408V

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

412S

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

413L

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

416S

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

427A

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

428N

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

431M

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

432F

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

435Y

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

436C

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

439N

putative substrate translocation pore
84K, 87L, 88S, 89Y, 91A, 92I, 110S, 113F, 114Y, 117F, 121S, 122V, 124T, 125N, 171E, 172C, 175D, 176P, 179M, 180L, 183G, 195I, 196G, 199F, 200S, 206V, 307N, 310N, 311G, 314S, 315N, 318T, 331T, 335S, 339G, 342I, 346I, 401G, 404Y, 405A, 408V, 412S, 413L, 416S, 427A, 428N, 431M, 432F, 435Y, 436C, 439N
CDD
cd06174 (MFS)

Protein sequence

>MIA_02319_1
MTASEKDTPIHDESIQKGPDVYEVEDIKDNVDFSKMDKAAAIMHNNEINLEDIDPKEIARITRKVDMMILPFIFVSYIFF
YVDKTTLSYAAIFGITKDLQLTGDKYSWLSSVFYFGFLAWSVPTNYLMLKFPIAKYLGINIFMWGVFLMIQAACTNFRSL
VVLRILGGAAECCADPAFMLITGMWYTRRQQPVRIGIWFSATGIGVAFGGLLGYGIGNIKGSLPSWKYEFLIIGAICALW
GIIVFFFLPDSPVTSKYLTEDERVILLNILKSNQTGIENKTLKWDQVKECLLDIKVWLLFFGVLGANVPNGGYSNFGTII
IKGLGFSTLGTTLLSIPYGASIALSILLCVYLNNILSRNGKNTRVLLLALFVLPNIAGTFGLYFLPQHRKGGRLACYYLT
GPGYASFVLVLSLFSSNFAGHTKRTVANTIMFLGYCIGNLIGPFFYLDSQKPRYPLGIGSMLTGTMVSAGTGIILGFYLR
YCNSKRDKEQGGRTEDLSNAFMDMTDIQNKNFRYVY

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features