Protein

MIA_02262_1

Length
974 amino acids

Browser: contig03:304898-307823-

Protein function

EGGNOG:0PIVRPGUG_01652ubiquitin carboxyl-terminal hydrolase
SGD closest match:S000000953UBP3Ubiquitin carboxyl-terminal hydrolase 3
CGD closest match:CAL0000199093orf19.6319mRNA-binding ubiquitin-specific protease

Protein alignments

%idAln lengthE-value
A0A0J9X7J1_GEOCN48.276%4645.43e-130Similar to Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi OS=Geotrichum candidum GN=BN980_GECA05s01649g PE=3 SV=1
UniRef50_A0A0J9X7J148.276%4641.11e-126Similar to Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X7J1_GEOCN
MCA_01908_147.692%4553.45e-118MCA_01908_1
A0A060T4M6_BLAAD39.036%4159.37e-86ARAD1B00748p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B00748g PE=3 SV=1
A0A167FV26_9ASCO38.940%4341.17e-80mRNA-binding ubiquitin-specific protease UBP3 OS=Sugiyamaella lignohabitans GN=UBP3 PE=3 SV=1
A0A1E3PP05_9ASCO37.097%4342.68e-75Cysteine proteinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45356 PE=3 SV=1
A0A1D8PP95_CANAL34.071%4521.05e-60mRNA-binding ubiquitin-specific protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6319 PE=3 SV=1
Q6C6K5_YARLI33.496%4091.14e-55YALI0E08844p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E08844g PE=3 SV=1
UBP3_YEAST29.259%4992.69e-48Ubiquitin carboxyl-terminal hydrolase 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP3 PE=1 SV=1
A0A1E4TJM5_9ASCO26.810%3735.42e-32Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_55713 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0002
Predicted cleavage: 150

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 974

Detailed signature matches

  1. Domain IPR011990
    Tetratricopeptide-like helical domain
    1. G3DSA:1.25.40.10
  2. Domain IPR028889
    Ubiquitin specific protease domain
    1. PS50235 (USP_3)
  3. Domain IPR001394
    Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    1. PF00443 (UCH)
  4. SITE IPR018200
    Ubiquitin specific protease, conserved site
    1. PS00972 (USP_1)
    2. PS00973 (USP_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.90.70.10
  3. SSF54001 (Cysteine ...)
  4. cd02257 (Peptidase_C19)
  5. mobidb-lite (disord...)

Residue annotation

  1. Active Site cd02257
  2. Active Site cd02257

Protein sequence

>MIA_02262_1
MSNYSGYAATHQQPPLYYPSQNGFTPPIFYDNSPIMYGMASSPSMPNGVLHDYAGPPVSHGGNYGSGSIPNGGHSHHGGN
GNNQHRQNKHSKSSDHYGNNNHYRSKYHRHHNNNPHNSTNNNNSNAHGYQYHQGHQLTYRPFYPSQPPADFGSPQGLQSL
PMHHPSHIHHPPPFIPGADPSDAEALLDLTPHHPALPPLTSPPPPLSALGAPPPHTLPHLHIPTHPRHPPPPHPPPHHHL
HSTAHHSPTPGVTPSPKKKPVVLSDPNSSEFGEKSGNGSSTSISSNNSTGNNANKINDKVSVDNNSSSSSSSNDSRSSSS
NASATTATTASSSPKSKPSASKSQTEREEFVHCGGQITKVWFSAPNEPFPKRRAYYRRLEKLKKEREEAKRRKEEEAKKQ
AEKDTTSLDTEERVLSPAPTINSASASTSVKPSTPLPKSPVALSPVPVIIPAAPAISLAAETTTTEASPVAGSRTGTPAV
AAATPTVSKGISWAERLQQDNHADNLPVSPRKAYVNGTNGSTSNSITSSSNGSSIPAVHEKKTIKVANQKEPLGVVLHNY
DYKKVKNLAVPRIYSRGIINTGNICFMNSILQALVHCLPFYQLLEYIASNSVFSIKSETPLMDALINLTRECAEKPKDSS
KSINSQPLSPEAFYNTVRAHPRFVHYKRGRQEDAEEFLGYLLEALHDEFVGVMNATALKKEEEEAEEKKGAEEEGWQEVG
KNNKSMSVQQNKGFGESPVTRLFGGQLKSTLTASNLKTPSITRDPFQQIQLDISDEQVRSIEDAFVNLAQPEQLQYSTST
KQEVRATKQIVIDEVPEVLIVHLKRFSYTNDGDDLSGGAGGGALGSNGYVGAGGSGLQVPFAVENVQKISKPVTFPEQLR
LPREAVGSGALPPPTYTLSAVVYHHGPSAAAGHYTVDVKSVSGEGSEAREEWVNIDDVTLTKGVAAAGGGGVEVGSGTKT
AYILFYRRESGGHQ

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Molecular Function

GO:0005515 protein binding
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Cellular Component

None predicted.