MIA_02099_1

Protein

Length

322 amino acids

Protein function

EGGNOG:	0PJYN		short chain dehydrogenase
CGD closest match:	CAL0000195024	CAALFM_CR07170WA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
A0A0J9XKM6_GEOCN	55.873%	315	2.60e-120	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA25s00549g PE=4 SV=1
MCA_01315_1	53.968%	315	1.38e-119	MCA_01315_1
UniRef50_R7RYV8	49.691%	324	2.65e-90	NAD-P-binding protein n=9 Tax=Dikarya TaxID=451864 RepID=R7RYV8_STEHR
A0A060TAG7_BLAAD	24.510%	204	3.89e-09	ARAD1D19030p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D19030g PE=4 SV=1
A0A1E4TBX3_9ASCO	26.087%	207	3.23e-07	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_29448 PE=4 SV=1
A0A1D8PTE1_CANAL	24.159%	327	1.91e-06	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR07170WA PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0286
Predicted cleavage: 15

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
11 - 314
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 322

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PR00081 (GDHRDH)
  
  17 - 34
  
  PRINTS
  PR00081 (GDHRDH)
  
  240 - 257
  
  PRINTS
  PR00081 (GDHRDH)
  
  277 - 297
  
  PRINTS
  PR00081 (GDHRDH)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  11 - 314
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

3 - 321

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PF13561 (adh_short_C2)

109 - 313

Pfam
PF13561 (adh_short_C2)
cd05233 (SDR_c)

18 - 311

CDD
cd05233 (SDR_c)
mobidb-lite (disord...)

59 - 101

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

NAD(P) binding sit...

22G

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

24S

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

25G

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

26A

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

27I

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

49L

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

50R

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

51H

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

113V

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

114D

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

115V

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

141C

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

142A

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

143A

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

169V

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

201I

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

202G

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

203S

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

216Y

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

220K

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

249P

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

250G

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

251P

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

252V

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

254T

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)

255E

NAD(P) binding site
22G, 24S, 25G, 26A, 27I, 49L, 50R, 51H, 113V, 114D, 115V, 141C, 142A, 143A, 169V, 201I, 202G, 203S, 216Y, 220K, 249P, 250G, 251P, 252V, 254T, 255E
CDD
cd05233 (SDR_c)
active site cd05233

170N

active site
170N, 203S, 216Y, 220K
CDD
cd05233 (SDR_c)

203S

active site
170N, 203S, 216Y, 220K
CDD
cd05233 (SDR_c)

216Y

active site
170N, 203S, 216Y, 220K
CDD
cd05233 (SDR_c)

220K

active site
170N, 203S, 216Y, 220K
CDD
cd05233 (SDR_c)

Protein sequence

>MIA_02099_1
MLNPRPIDLSLGLENTHVLVTGGSGAIGQVIVDAFLQAGAKVSVFELVLRHEKQSPSAIHVPAQLPTPTTSPPIMSTSPL
SSSSRPATEPSPPPSLLDESPRPACDRFMEYRVDVSQPAQLSRGFALAAAHFGLIQVCVACAAQDLSYLAHHASLIDLPF
AQWQQTFSVNVHGTFLTAQEWLRQVRDGADQHTKNLSLVVIGSESGRFGELGNADYASGKSAVQYGLVNSLVKDVVQIHP
RARVNAVAPGPVDTEKFHEECALNPSQYYEDCQATTAMKRPTSIQGVARTILFLASENWSGDITGQVINVDGGKNGKLFW
NI

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_02099_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component