MIA_02047_1

Protein

Length

449 amino acids

Protein function

EGGNOG:	0PG05	SAH1	adenosylhomocysteinase
SGD closest match:	S000000845	SAH1	Adenosylhomocysteinase
CGD closest match:	CAL0000201641	SAH1	Adenosylhomocysteinase

Protein alignments

	%id	Aln length
MCA_04710_1	93.99%	449	MCA_04710_1
Q6C211_YARLI	88.86%	449	Adenosylhomocysteinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F11759g PE=3 SV=1
A0A0J9XBL7_GEOCN	88.99%	445	Adenosylhomocysteinase OS=Geotrichum candidum GN=BN980_GECA08s01792g PE=3 SV=1
A0A060T8F3_BLAAD	87.97%	449	Adenosylhomocysteinase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C28974g PE=3 SV=1
A0A1E3PL10_9ASCO	85.91%	447	Adenosylhomocysteinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46565 PE=3 SV=1
A0A167DK67_9ASCO	85.84%	445	Adenosylhomocysteinase OS=Sugiyamaella lignohabitans GN=SAH1 PE=3 SV=1
A0A1E4TKG5_9ASCO	83.89%	447	Adenosylhomocysteinase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_833 PE=3 SV=1
SAHH_CANAL	83.93%	448	Adenosylhomocysteinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SAH1 PE=1 SV=2
SAHH_YEAST	82.85%	449	Adenosylhomocysteinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SAH1 PE=1 SV=1
UniRef50_P39954	82.85%	449	Adenosylhomocysteinase n=780 Tax=root TaxID=1 RepID=SAHH_YEAST

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0414

Protein family membership

Adenosylhomocysteinase-like (IPR000043)
- Adenosylhomocysteinase (IPR034373)

Domains and repeats

Domain
194 - 355
S-adenosyl-L-homocysteine hydrolase, NAD binding domain (IPR015878)
Domain
194 - 355
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 350 400 449

Detailed signature matches

IPR000043

Adenosylhomocysteinase-like
1. PF05221 (AdoHcyase)
  
  7 - 144
  
  Pfam
  PF05221 (AdoHcyase)
2. SM00996 (AdoHcyase_2)
  
  7 - 448
  
  SMART
  SM00996 (AdoHcyase_2)
3. TIGR00936
  
  8 - 441
  
  TIGRFAMs
  TIGR00936 (TIGR00936)
4. cd00401 (SAHH)
  
  17 - 436
  
  CDD
  cd00401 (SAHH)
5. PIRSF001109 (SAHH)
  
  1 - 449
  
  PIRSF
  PIRSF001109 (SAHH)
IPR034373

Adenosylhomocysteinase
1. MF_00563 (AdoHcyase)
  
  3 - 441
  
  HAMAP
  MF_00563 (AdoHcyase)
IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain
1. PF00670 (AdoHcyase_NAD)
  
  194 - 355
  
  Pfam
  PF00670 (AdoHcyase_NAD)
2. SM00997 (AdoHcyase_...)
  
  194 - 355
  
  SMART
  SM00997 (AdoHcyase_NAD_2)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  194 - 355
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site
1. PS00739 (ADOHCYASE_2)
  
  216 - 232
  
  PROSITE patterns
  PS00739 (ADOHCYASE_2)
2. PS00738 (ADOHCYASE_1)
  
  79 - 93
  
  PROSITE patterns
  PS00738 (ADOHCYASE_1)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

211 - 422

GENE3D
G3DSA:3.40.50.1480 (G3DSA:3.40.50.1480)

1 - 145

GENE3D
G3DSA:3.40.50.1480 (G3DSA:3.40.50.1480)

146 - 210

GENE3D
G3DSA:3.40.50.1480 (G3DSA:3.40.50.1480)
SSF52283 (Formate/g...)

356 - 449

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)

5 - 193

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)

Residue annotation

homotetramer inter...

18F

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

21K

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

25L

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

28N

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

29E

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

165H

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

168Y

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

169K

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

185D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

187V

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

191K

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

192F

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

196Y

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

199R

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

200E

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

204D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

207K

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

208R

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

211D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

212V

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

213M

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

214I

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

215A

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

216G

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

217K

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

225G

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

226D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

229K

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

238M

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

239G

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

241K

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

246E

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

247I

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

248D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

249P

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

250I

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

251N

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

252A

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

253L

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

254Q

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

256A

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

257V

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

258S

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

259G

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

261P

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

262V

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

263K

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

264T

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

267D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

280G

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

281C

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

282R

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

283D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

284I

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

294R

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

295N

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

296D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

307I

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

324I

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

325K

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

330R

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

354T

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

357S

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

359F

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

360V

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

363C

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

402V

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

408D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

409E

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

412A

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

413R

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

416L

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

419L

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

420D

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

422N

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

423L

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

424S

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

426L

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

429V

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

430Q

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

433Y

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)

434L

homotetramer interface
18F, 21K, 25L, 28N, 29E, 165H, 168Y, 169K, 185D, 187V, 191K, 192F, 196Y, 199R, 200E, 204D, 207K, 208R, 211D, 212V, 213M, 214I, 215A, 216G, 217K, 225G, 226D, 229K, 238M, 239G, 241K, 246E, 247I, 248D, 249P, 250I, 251N, 252A, 253L, 254Q, 256A, 257V, 258S, 259G, 261P, 262V, 263K, 264T, 267D, 280G, 281C, 282R, 283D, 284I, 294R, 295N, 296D, 307I, 324I, 325K, 330R, 354T, 357S, 359F, 360V, 363C, 402V, 408D, 409E, 412A, 413R, 416L, 419L, 420D, 422N, 423L, 424S, 426L, 429V, 430Q, 433Y, 434L
CDD
cd00401 (SAHH)
catalytic site cd0...

56H

catalytic site
56H, 134D, 159E, 193D
CDD
cd00401 (SAHH)

134D

catalytic site
56H, 134D, 159E, 193D
CDD
cd00401 (SAHH)

159E

catalytic site
56H, 134D, 159E, 193D
CDD
cd00401 (SAHH)

193D

catalytic site
56H, 134D, 159E, 193D
CDD
cd00401 (SAHH)
ligand binding sit...

56H

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

58T

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

60Q

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

61T

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

134D

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

159E

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

160T

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

189K

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

193D

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

350L

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

355G

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

356H

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

361M

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)

365F

ligand binding site
56H, 58T, 60Q, 61T, 134D, 159E, 160T, 189K, 193D, 350L, 355G, 356H, 361M, 365F
CDD
cd00401 (SAHH)
NAD binding site c...

160T

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

161T

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

162T

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

194N

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

198C

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

223G

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

225G

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

226D

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

227V

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

245T

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

246E

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

247I

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

248D

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

251N

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

278T

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

279T

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

280G

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

281C

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

284I

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

302I

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

303G

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

304H

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

347L

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

349N

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

356H

NAD binding site
160T, 161T, 162T, 194N, 198C, 223G, 225G, 226D, 227V, 245T, 246E, 247I, 248D, 251N, 278T, 279T, 280G, 281C, 284I, 302I, 303G, 304H, 347L, 349N, 356H
CDD
cd00401 (SAHH)

Protein sequence

>MIA_02047_1
MSAPATNYKVADIGLAAFGRKEIELAENEMPGLIETRKKYASVQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWSSC
NIFSTQDHAAAAIAAAGVPVFAWKGETEEEYIWCIEQQLNAFKDGKKLNLILDDGGDLTRLVHEKYPELLEDCFGLSEET
TTGVHHLYKMVKEGTLKVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKTAVVAGFGDVGKGCALALQSMGA
KVIVTEIDPINALQAAVSGYPVKTMEDAAAVGQIFVTTTGCRDIITGEHFKVMRNDAIVCNIGHFDIEIDVAWLKANAKS
HVNIKPGVDRYLMESGSHIILLAEGRLVNLGCATGHSSFVMSCSFTNQVLAQIALFNSKNEEFLAKHVEFAKSGPFNVGV
HVLPKILDETVARLHLKHLDVNLSVLSPVQSDYLGIAPEGPYKADIYRY

GO term prediction

Biological Process

GO:0006730 one-carbon metabolic process
GO:0019510 S-adenosylhomocysteine catabolic process

Molecular Function

GO:0004013 adenosylhomocysteinase activity
GO:0051287 NAD binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features