Protein

MIA_01559_1

Length
372 amino acids

Browser: contig02:1072848-1074016+

Protein function

EGGNOG:0PJMDPGUG_00082ribonuclease H
SGD closest match:S000004847RNH1Ribonuclease H
CGD closest match:CAL0000191701RNH1Rnh1p

Protein alignments

%idAln lengthE-value
MCA_05772_255.78%1471e-47MCA_05772_2
UniRef50_W9CG2933.75%3231e-43Ribonuclease H n=2 Tax=Leotiomycetes TaxID=147548 RepID=W9CG29_9HELO
A0A161HJH2_9ASCO35.92%3092e-46Ribonuclease H OS=Sugiyamaella lignohabitans GN=RNH1 PE=3 SV=1
A0A0J9X3A6_GEOCN48.00%1504e-35Ribonuclease H OS=Geotrichum candidum GN=BN980_GECA01s10097g PE=3 SV=1
A0A060TD98_BLAAD44.23%1562e-31Ribonuclease H OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D41536g PE=3 SV=1
Q6CHD9_YARLI31.35%2522e-26Ribonuclease H OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A09878g PE=3 SV=1
A0A1E3PU38_9ASCO36.53%1679e-26Ribonuclease H OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49110 PE=3 SV=1
Q5ABY8_CANAL32.64%2392e-25Rnh1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RNH1 PE=4 SV=1
RNH1_YEAST26.49%3703e-20Ribonuclease H OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RNH1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2420
Predicted cleavage: 13

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 372

Detailed signature matches

  1. Family IPR017067
    Ribonuclease H1, eukaryote
    1. PIRSF036852 (RNase_...)
  2. Domain IPR009027
    Ribosomal protein L9/RNase H1, N-terminal
    1. SSF55658 (L9 N-doma...)
  3. Domain IPR011320
    Ribonuclease H1, N-terminal
    1. PF01693 (Cauli_VI)
    2. G3DSA:3.40.97...
  4. Domain IPR012337
    Ribonuclease H-like domain
    1. SSF53098 (Ribonucle...)
    2. G3DSA:3.30.42...
  5. Domain IPR002156
    Ribonuclease H domain
    1. PF00075 (RNase_H)
    2. PS50879 (RNASE_H)
Unintegrated signatures no IPR
Unintegrated signatures
  1. TMhelix
  2. cd09280 (RNase_HI_e...)

Residue annotation

  1. active site cd09280
  2. RNA/DNA hybrid bin...

Protein sequence

>MIA_01559_1
MQSVDRFTNARWKVFKSYKEAVLFVKEADTDLKNISDTGRYYAVRRGRKTGIFSTWYVYLIELNTVLTGFFFYRDETKEV
IGGYRKAEYKLFKNQKEAEAYIDENPYADLVANSTGKFYAVKSGRQSGIFETAEEAIKHTLNFSHQEIKRFDEYDTAKEY
LQEMMGDKQASCEEGLLSLKTNNNNNEEKERICNVYTDGSSRGNGMCGAVAGVGVFYGDGDRRNVSRLLGSGSQTNNRAE
LSAVIDALLQAQLDRPDRLNIYSDSQYSIDLMTTLRSKWEERVYRRGNGKWMLNADLIQQGHQLLNELDKLNVSVAFHQI
KGHSDNYGNTQADKLANQGATMEGGYVRVADKDVEAEQKEEQQIWELLMDTP

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

Cellular Component

None predicted.