Protein
MIA_01527_1
Length
150 amino acids
Browser: contig02:989560-990046+
Protein function
| EGGNOG: | 0PPKY | COF1 | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1 1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity) |
|---|---|---|---|
| SGD closest match: | S000003973 | COF1 | Cofilin |
| CGD closest match: | CAL0000176762 | COF1 | Cofilin |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| COFI_YARLI | 61.806% | 144 | 6.06e-64 | Cofilin OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=COF1 PE=3 SV=1 |
| A0A1E3PQZ4_9ASCO | 59.459% | 148 | 2.95e-63 | Cofilin OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_63370 PE=3 SV=1 |
| A0A1E4TAN4_9ASCO | 61.111% | 144 | 3.51e-63 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_128855 PE=3 SV=1 |
| UniRef50_G8Y1W9 | 61.538% | 143 | 3.57e-59 | Piso0_005335 protein n=9 Tax=Dikarya TaxID=451864 RepID=G8Y1W9_PICSO |
| A0A060SZ67_BLAAD | 62.963% | 135 | 2.32e-60 | ARAD1A18018p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A18018g PE=3 SV=1 |
| COFI_YEAST | 57.639% | 144 | 1.96e-59 | Cofilin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COF1 PE=1 SV=1 |
| A0A0J9XLF6_GEOCN | 59.722% | 144 | 2.77e-59 | Similar to Saccharomyces cerevisiae YLL050C COF1 Cofilin, involved in pH-dependent actin filament depolarization OS=Geotrichum candidum GN=BN980_GECA32s02463g PE=3 SV=1 |
| A0A1D8PMW6_CANAL | 54.861% | 144 | 1.19e-55 | Cofilin OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=COF1 PE=3 SV=1 |
| MCA_05762_1 | 53.793% | 145 | 4.37e-55 | MCA_05762_1 |
| A0A167E6G9_9ASCO | 32.039% | 103 | 6.66e-06 | Twf1p OS=Sugiyamaella lignohabitans GN=TWF1 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0093
Protein family membership
- ADF/Cofilin (IPR017904)
Domains and repeats
-
Domain
1
20
40
60
80
100
120
140
150
Detailed signature matches
-
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cd11286 (ADF_cofili...)
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no IPR
Unintegrated signatures
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NON_CYTOPLASM... (N...)
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SIGNAL_PEPTIDE (Sig...)
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SIGNAL_PEPTID... (S...)
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SIGNAL_PEPTID... (S...)
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SIGNAL_PEPTID... (S...)
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SSF55753 (Actin dep...)
-
Residue annotation
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putative F-actin i...
Protein sequence
>MIA_01527_1 MYIITFLSIHSVVVADEAIEAFNELKQAKSKVKYVIYKLSEDLKSIVVDKKSTDSKYDDFVNDLPETDCRYAVYDFEYET QSGEGIRNKLIFFSWSPDTAKVKSKMVYASSKDAIRRSLPGITNEIQGTDLDEIAYDTVLERVSRSAGSH
GO term prediction
Biological Process
GO:0030042 actin filament depolymerization
Molecular Function
GO:0003779 actin binding
Cellular Component
GO:0005622 intracellular
GO:0015629 actin cytoskeleton