Protein

MIA_01520_1

Length
235 amino acids

Browser: contig02:953668-954376+

Protein function

EGGNOG:0PFVXFG07536.1mitochondrial peroxiredoxin Prx1
SGD closest match:S000000160PRX1Mitochondrial peroxiredoxin PRX1
CGD closest match:CAL0000196398PRX1Thioredoxin peroxidase

Protein alignments

%idAln lengthE-value
A0A0J9X7Q7_GEOCN82.19%2192e-137Similar to Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides OS=Geotrichum candidum GN=BN980_GECA04s05422g PE=4 SV=1
Q6CGH1_YARLI79.36%2184e-131YALI0A19426p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A19426g PE=4 SV=1
A0A167CSD8_9ASCO76.68%2233e-131Prx1p OS=Sugiyamaella lignohabitans GN=PRX1 PE=4 SV=1
A0A060TGX2_BLAAD78.54%2193e-130ARAD1D26576p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26576g PE=4 SV=1
A0A1E3PSR3_9ASCO77.78%2163e-128Thioredoxin-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81075 PE=4 SV=1
UniRef50_A0A165JG6574.67%2251e-111Uncharacterized protein n=13 Tax=leotiomyceta TaxID=716546 RepID=A0A165JG65_9PEZI
Q5A5A0_CANAL66.67%2164e-108Thioredoxin peroxidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRX1 PE=4 SV=1
A0A1E4TGA0_9ASCO67.92%2125e-107Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2521 PE=4 SV=1
PRX1_YEAST61.14%2114e-90Mitochondrial peroxiredoxin PRX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRX1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2389
Predicted cleavage: 14

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 235

Detailed signature matches

  1. Family IPR024706
    Peroxiredoxin, AhpC-type
    1. PIRSF000239 (AHPC)
  2. Domain IPR012336
    Thioredoxin-like fold
    1. SSF52833 (Thioredox...)
  3. Domain IPR013766
    Thioredoxin domain
    1. PS51352 (THIOREDOXIN_2)
  4. Domain IPR000866
    Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
    1. PF00578 (AhpC-TSA)
  5. Domain IPR019479
    Peroxiredoxin, C-terminal
    1. PF10417 (1-cysPrx_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.10...
  2. G3DSA:3.40.30.10
  3. SFLDS00024 (Peroxir...)
  4. cd03016 (PRX_1cys)

Residue annotation

  1. dimer interface cd...
  2. decamer (pentamer ...
  3. SFLDS00024
  4. catalytic triad cd...

Protein sequence

>MIA_01520_1
MSIPAPKNGTLRLGSKAPDFSADTSNGPINFYDWAGDSWVVFFSHPDDFTPVCTTELGAFARLQPEFTKRGVKLIGLSAN
DTSSHNAWIRDINELSNTNLTFPIVADPKREVAQLYDMIDFQDATNLDDKGVQLTIRSVFIIDPKKTIRLILSYPASTGR
NTAEVLRVVDSLQTGDKHRVTTPINWTPGEDVIVHPSVSNDEAKTLFPKFRIVKPYLRLTPLDLSDSNPKGDAKL

GO term prediction

Biological Process

GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0051920 peroxiredoxin activity

Cellular Component

None predicted.