MIA_01508_1

Protein

Length

539 amino acids

Protein function

EGGNOG:	0PFF2	FG04799.1	transporter
SGD closest match:	S000005009	AQR1	Probable transporter AQR1
CGD closest match:	CAL0000179742	QDR2	MFS antiporter QDR2

Protein alignments

	%id	Aln length	E-value
MCA_01246_1	64.607%	534	0.0	MCA_01246_1
A0A0J9X3J0_GEOCN	51.373%	510	5.67e-144	Similar to Saccharomyces cerevisiae YNL065W AQR1 Plasma membrane multidrug transporter of the major facilitator superfamily OS=Geotrichum candidum GN=BN980_GECA01s03805g PE=4 SV=1
UniRef50_A0A0J9X494	50.588%	510	6.18e-139	Similar to Saccharomyces cerevisiae YNL065W AQR1 Plasma membrane multidrug transporter of the major facilitator superfamily n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X494_GEOCN
A0A167F432_9ASCO	46.654%	523	2.57e-130	Qdr2p OS=Sugiyamaella lignohabitans GN=QDR2 PE=4 SV=1
A0A1E3PGV9_9ASCO	44.106%	492	6.13e-126	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83453 PE=4 SV=1
A0A060TCH4_BLAAD	42.015%	526	1.62e-121	ARAD1D36146p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D36146g PE=4 SV=1
Q6C300_YARLI	40.952%	525	2.25e-105	YALI0F03751p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F03751g PE=4 SV=1
QDR2_CANAL	36.948%	498	1.91e-88	MFS antiporter QDR2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=QDR2 PE=3 SV=1
AQR1_YEAST	35.772%	492	3.72e-78	Probable transporter AQR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AQR1 PE=1 SV=1
A0A1E4TAB1_9ASCO	37.555%	458	1.96e-74	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3307 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0011

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
53 - 522
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 500 539

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  72 - 480
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  66 - 519
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  53 - 252
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  401 - 522
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  288 - 368
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  68 - 513
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1 - 63

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

370 - 404

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

241 - 306

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

514 - 539

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

121 - 131

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

451 - 461

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

179 - 189

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

53 - 251

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

291 - 531

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

210 - 220

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

484 - 494

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

328 - 346

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

424 - 428

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

151 - 155

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

88 - 101

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

65 - 87

TMHMM
TMhelix (TMhelix)

427 - 449

TMHMM
TMhelix (TMhelix)

307 - 329

TMHMM
TMhelix (TMhelix)

131 - 150

TMHMM
TMhelix (TMhelix)

462 - 484

TMHMM
TMhelix (TMhelix)

339 - 361

TMHMM
TMhelix (TMhelix)

156 - 178

TMHMM
TMhelix (TMhelix)

404 - 423

TMHMM
TMhelix (TMhelix)

494 - 513

TMHMM
TMhelix (TMhelix)

216 - 238

TMHMM
TMhelix (TMhelix)

102 - 124

TMHMM
TMhelix (TMhelix)

190 - 212

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

429 - 450

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

307 - 327

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

495 - 513

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

405 - 423

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

347 - 369

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

190 - 209

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

132 - 150

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

462 - 483

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

156 - 178

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

102 - 120

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

221 - 240

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

64 - 87

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

81V

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

84Y

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

85L

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

86P

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

88L

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

89T

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

106I

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

109Y

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

110S

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

113Q

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

117P

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

118A

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

120W

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

121G

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

167M

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

168A

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

171V

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

172A

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

175A

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

176G

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

179G

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

191M

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

192G

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

195G

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

196G

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

202N

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

318Y

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

321W

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

322F

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

325L

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

326T

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

329S

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

343L

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

347Y

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

351G

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

354S

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

358S

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

436T

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

439I

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

440S

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

446F

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

450S

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

451N

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

454M

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

465A

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

466S

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

469V

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

470N

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

473R

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

474C

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

477C

putative substrate translocation pore
81V, 84Y, 85L, 86P, 88L, 89T, 106I, 109Y, 110S, 113Q, 117P, 118A, 120W, 121G, 167M, 168A, 171V, 172A, 175A, 176G, 179G, 191M, 192G, 195G, 196G, 202N, 318Y, 321W, 322F, 325L, 326T, 329S, 343L, 347Y, 351G, 354S, 358S, 436T, 439I, 440S, 446F, 450S, 451N, 454M, 465A, 466S, 469V, 470N, 473R, 474C, 477C
CDD
cd06174 (MFS)

Protein sequence

>MIA_01508_1
MENPDECYPKKKLEDLKYSVENTAENTTNVLYGNPEEGISEKEITEQTAEEDEPYTIFSVSEKYFLSLFASFLALFSAIS
VPIYLPVLTELENYFHVDTEKINLTIVTYSIFQGIAPAFWGPLADKFGRRPIYPLCLIIYIGANIGLAMAKSYGMLLGFR
CLQAAGMAASVAIGAGLVGDITQRKDRGTFMGLFGGFTLLGNAVGPLIGAGLASTWIWRSIFWFLVICASVALLIVIIVL
PETNRSFVGNGSVRPYRIVNLSPVMAIVHGKRLIPYETAVATGKGLLNPPKNSSILRTFQLFLNKDVALVLIPSGLHYTA
WFVALTIQSTALTQDYHFTTIQLGISYLANGVGSVAGSVWGGRLLTWYYKKQATKFKEKWTLDHGIDSKPDPFHFDIVKT
RITPGFYLSPIMVITSIIFGWTIEKHVHWIVPIIMTFFISITGVTFVNISNTLMVDLFPQDSSSASACVNLVRCLLCAVG
LAVTDKMNLKLGTGGTMTLISGICILSLVSYAIEYKYGLKWNQERSFKNNDQKASALYS

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features