MIA_01395_1

Protein

Length

517 amino acids

Protein function

EGGNOG:	0QDB6	PGUG_04452	Monocarboxylate transporter
SGD closest match:	S000005833	MCH5	Riboflavin transporter MCH5
CGD closest match:	CAL0000190473	orf19.5720	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_00626_1	62.712%	413	0.0	MCA_00626_1
A0A0J9X330_GEOCN	61.408%	412	1.88e-178	Similar to Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases OS=Geotrichum candidum GN=BN980_GECA01s08436g PE=4 SV=1
UniRef50_A0A0J9YHP1	53.563%	407	5.95e-147	Similar to Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases n=3 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9YHP1_GEOCN
W0TYN6_YARLI	46.751%	477	1.42e-131	YALI0B04004p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B04004g PE=4 SV=1
MCH5_YEAST	40.000%	425	1.06e-101	Riboflavin transporter MCH5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCH5 PE=1 SV=2
A0A167D661_9ASCO	38.312%	462	1.81e-96	Mch4p OS=Sugiyamaella lignohabitans GN=MCH4 PE=4 SV=1
A0A1D8PQ72_CANAL	42.410%	415	5.67e-94	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5720 PE=4 SV=1
A0A060TFU5_BLAAD	36.867%	415	5.25e-85	ARAD1D17292p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D17292g PE=4 SV=1
A0A1E3PDP2_9ASCO	29.864%	442	2.55e-57	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84190 PE=4 SV=1
A0A1E4TLK5_9ASCO	28.764%	445	2.66e-39	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1237 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0656

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
91 - 509
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 517

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  119 - 471
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  111 - 509
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  91 - 509
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  115 - 504
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

510 - 517

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

292 - 329

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 114

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

170 - 180

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

383 - 393

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

449 - 459

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

230 - 240

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

109 - 300

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

321 - 506

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

141 - 151

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

416 - 420

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

260 - 270

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

482 - 486

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

202 - 206

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

358 - 362

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

153 - 175

TMHMM
TMhelix (TMhelix)

268 - 290

TMHMM
TMhelix (TMhelix)

456 - 478

TMHMM
TMhelix (TMhelix)

365 - 387

TMHMM
TMhelix (TMhelix)

488 - 510

TMHMM
TMhelix (TMhelix)

333 - 355

TMHMM
TMhelix (TMhelix)

421 - 443

TMHMM
TMhelix (TMhelix)

394 - 416

TMHMM
TMhelix (TMhelix)

208 - 230

TMHMM
TMhelix (TMhelix)

179 - 201

TMHMM
TMhelix (TMhelix)

110 - 132

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

421 - 448

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

152 - 169

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

330 - 357

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

115 - 140

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

460 - 481

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

363 - 382

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

207 - 229

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

181 - 201

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

241 - 259

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

487 - 509

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

271 - 291

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

394 - 415

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

129L

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

132S

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

133L

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

134G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

136I

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

137Q

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

157F

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

160F

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

161L

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

164C

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

168A

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

169G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

171V

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

172G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

219C

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

220A

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

223M

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

224T

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

227I

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

228A

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

231G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

242I

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

243G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

246T

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

247V

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

253G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

342L

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

345V

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

346N

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

349T

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

350F

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

353S

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

365S

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

369L

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

373N

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

376G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

380R

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

430G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

433N

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

434G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

437L

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

441P

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

442V

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

445G

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

456R

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

457Y

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

460M

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

461F

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

464T

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

465S

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

468C

putative substrate translocation pore
129L, 132S, 133L, 134G, 136I, 137Q, 157F, 160F, 161L, 164C, 168A, 169G, 171V, 172G, 219C, 220A, 223M, 224T, 227I, 228A, 231G, 242I, 243G, 246T, 247V, 253G, 342L, 345V, 346N, 349T, 350F, 353S, 365S, 369L, 373N, 376G, 380R, 430G, 433N, 434G, 437L, 441P, 442V, 445G, 456R, 457Y, 460M, 461F, 464T, 465S, 468C
CDD
cd06174 (MFS)

Protein sequence

>MIA_01395_1
MSFEPSSSSATDGIQHRRASVAGASGFEKMTVVDDALVEVRVKSTAVEFENPIPETSNVFEEINAENETLSDEERQYVAG
MTQSGPNNITNNHVDIDDDDDYTEYPEGGLIAWRVVLGSFFGLFSVFGLINSLGAIQAYVNENQLSNRSDSQVSWIFSVF
LFLCYLLAGQVGPLFDAYGPYQLVIAGTCFYTLGIMMTSLASQYYQFFLAFSLCAGLGCALLMTPEIAIIGHWFKKRRGT
AIGAATVGGSLGGVIFPVMLRQMYSTAGYAWALRALGFINLGTLLLSLFLMKPRLESVAPSVAVSSQSKIASVFSLKNML
DVRSLRDKRYAWLVAGNFLGELGVVNGLTFITSYALAQGKSPNMSYALLAILNAVGMPGRWLPGLIADRWLGRFNTLILT
TTMAFLTIFIIWLPFGHTTAGLIVFCVLHGFCNGAILSLAPVCCGQICKTRDYGKRYGTMFFITSFACLLGIPLSGALIR
GTNYNNLVIFNGSLYVGTTLAVLVSRYYAVGMRLCKW

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features