Protein

MIA_01061_1

Length
311 amino acids

Browser: contig01:3040274-3041540-

Protein function

EGGNOG:0PJGUFG06220.1Translation initiation factor 2
SGD closest match:S000003767SUI2Eukaryotic translation initiation factor 2 subunit alpha
CGD closest match:CAL0000201409SUI2Translation initiation factor eIF2 subunit alpha

Protein alignments

%idAln lengthE-value
MCA_02861_189.667%3007.76e-178MCA_02861_1
A0A0J9X8P8_GEOCN80.000%3005.35e-158Similar to Saccharomyces cerevisiae YJR007W SUI2 Alpha subunit of the translation initiation factor eIF2 OS=Geotrichum candidum GN=BN980_GECA05s03343g PE=4 SV=1
A0A161HHF6_9ASCO81.818%2977.04e-156Translation initiation factor eIF2 subunit alpha OS=Sugiyamaella lignohabitans GN=SUI2 PE=4 SV=1
Q6CG42_YARLI76.768%2975.24e-146YALI0B01034p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B01034g PE=4 SV=1
A0A060T7Z4_BLAAD76.431%2975.65e-144ARAD1C32098p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C32098g PE=4 SV=1
A0A1E4TCT3_9ASCO70.946%2961.60e-138Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28487 PE=4 SV=1
UniRef50_P5628666.892%2962.43e-127Eukaryotic translation initiation factor 2 subunit alpha n=210 Tax=Eukaryota TaxID=2759 RepID=IF2A_SCHPO
A0A1E3PLG5_9ASCO70.588%2891.03e-128Nucleic acid-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82149 PE=4 SV=1
IF2A_YEAST65.068%2922.26e-115Eukaryotic translation initiation factor 2 subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUI2 PE=1 SV=1
Q5AAU7_CANAL63.322%2896.11e-115Translation initiation factor eIF2 subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SUI2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0354

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 311

Detailed signature matches

  1. Family IPR011488
    Translation initiation factor 2, alpha subunit
    1. PF07541 (EIF_2_alpha)
  2. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  3. Domain IPR022967
    RNA-binding domain, S1
    1. SM00316 (S1_6)
  4. Domain IPR003029
    S1 domain
    1. PS50126 (S1)
    2. PF00575 (S1)
  5. Domain IPR024054
    Translation initiation factor 2, alpha subunit, middle domain
    1. SSF116742 (eIF2alph...)
    2. G3DSA:1.10.15...
  6. Domain IPR024055
    Translation initiation factor 2, alpha subunit, C-terminal
    1. G3DSA:3.30.70...
    2. SSF110993 (eIF-2-al...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. cd04452 (S1_IF2_alpha)
  3. mobidb-lite (disord...)

Residue annotation

  1. kinase interaction...
  2. eIF2B interation s...
  3. protein synthesis ...

Protein sequence

>MIA_01061_1
MAEEVNTTSCRFYENKYPEVDDFVVVNVREIADMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKHVKVGRNEVVVVLRV
DTDKGYIDLSKRRVSPEDAAKAEDKYNKSKAVHSILRHVAEKHKYPLEKLYEKIGWPLSRKYGHAYEAFKLAITNPEQVF
EGIEAPSKAIMDDLLLQISRKLTPNPVKVRADIEVTCFSYEGVDAVKAALSAGEALNTEDIPVKVKLVAAPLFVLTSVSL
DKQKAIDRLTEAIEVIKTKIEAAGGHLIVKMAPKTVSETDDAELAKLMEKSEAETRQVAGDDDEESEDEED

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity

Cellular Component

None predicted.