MIA_01018_1

Protein

Length

570 amino acids

Browser: contig01:2919683-2921396-

Protein function

EGGNOG:	0PGSS		Major Facilitator Superfamily
SGD closest match:	S000001428	YIL166C	Uncharacterized transporter YIL166C
CGD closest match:	CAL0000201100	orf19.6520	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
A0A0J9YHM4_GEOCN	73.684%	513	0.0	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s06654g PE=4 SV=1
A0A167D9I1_9ASCO	63.209%	511	0.0	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_906 PE=4 SV=1
UniRef50_A3LWD0	63.511%	507	0.0	Putative allantoate permease n=276 Tax=Dikarya TaxID=451864 RepID=A3LWD0_PICST
A0A1E3PQH2_9ASCO	61.702%	517	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_19598 PE=4 SV=1
A0A1D8PQZ7_CANAL	59.404%	537	0.0	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6520 PE=4 SV=1
Q6CDV0_YARLI	57.117%	548	0.0	YALI0B21010p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B21010g PE=4 SV=1
A0A060T3B5_BLAAD	53.875%	542	0.0	ARAD1C35992p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C35992g PE=4 SV=1
YIQ6_YEAST	47.348%	509	8.31e-175	Uncharacterized transporter YIL166C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YIL166C PE=1 SV=1
A0A1E4TFX3_9ASCO	28.926%	484	5.55e-52	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2334 PE=4 SV=1
MCA_01039_1	26.398%	447	1.24e-45	MCA_01039_1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0144

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
91 - 532
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 570

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  115 - 493
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  91 - 532
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  111 - 494
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

533 - 570

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

466 - 476

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

196 - 206

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

260 - 270

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

374 - 384

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 105

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

328 - 557

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

98 - 301

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

498 - 511

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

228 - 238

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

407 - 441

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

292 - 350

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

124 - 176

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

477 - 496

TMHMM
TMhelix (TMhelix)

236 - 258

TMHMM
TMhelix (TMhelix)

380 - 402

TMHMM
TMhelix (TMhelix)

511 - 533

TMHMM
TMhelix (TMhelix)

351 - 373

TMHMM
TMhelix (TMhelix)

271 - 293

TMHMM
TMhelix (TMhelix)

442 - 464

TMHMM
TMhelix (TMhelix)

207 - 226

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

512 - 532

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

106 - 123

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

477 - 497

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

177 - 195

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

351 - 373

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

271 - 291

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

239 - 259

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

207 - 227

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

442 - 465

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

385 - 406

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

125R

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

128I

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

129S

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

130Q

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

132L

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

133S

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

151Q

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

154F

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

155K

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

158F

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

162E

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

163L

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

165S

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

166Q

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

212E

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

213G

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

216I

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

217A

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

220V

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

221S

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

224S

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

236L

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

237S

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

240W

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

241T

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

247N

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

361Y

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

364T

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

365S

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

368S

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

369A

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

372T

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

385T

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

389T

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

393N

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

396H

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

400L

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

450V

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

453A

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

454S

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

457I

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

461L

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

462V

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

465C

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

476T

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

477V

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

482Y

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

483N

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

486V

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

487Q

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

490G

putative substrate translocation pore
125R, 128I, 129S, 130Q, 132L, 133S, 151Q, 154F, 155K, 158F, 162E, 163L, 165S, 166Q, 212E, 213G, 216I, 217A, 220V, 221S, 224S, 236L, 237S, 240W, 241T, 247N, 361Y, 364T, 365S, 368S, 369A, 372T, 385T, 389T, 393N, 396H, 400L, 450V, 453A, 454S, 457I, 461L, 462V, 465C, 476T, 477V, 482Y, 483N, 486V, 487Q, 490G
CDD
cd06174 (MFS)

Protein sequence

>MIA_01018_1
MAHENKDKGDIVTEAKSTKEFPHEQTYVSTALAKSQDDEEIYELESEQALKRRKPFYGGKDHVFNDPEVAEYYREMYEKA
TYEGRFHFDPDFHWTPKDERKLLWKIELRACLWACIMFIGLQLDRGNISQALSDNMLKDLNMTTNNYNTGQTIFKVCFLA
AELPSQLISKKVGPDRWIPTQITIWSIVALCQCKLSGKGSFYATRALLGLLEGGFIADTVSWLSYFYTGTELPIRLSFFW
TALTVTNICASLLAFAILRMRGILGWEGWRWLFLLEGIFTLIIGLLSYIQLPPSPVQTKAWFRPKGWFTEFEEKLIVNRV
LRDDPSKGDMHNRQAVTLKQLWESLCDYDLWPLYFIGLVAYIPTSTVSAYLTLTLKQLGFSTFNTNLLTIPPNVAHIILL
LAQTWFTERINERTITCTLQPLWIIPCVGTLAFWSQSLNNVWGTYALLVVLLASPYIHAILVGWCSRNSNTVRSRTVSAA
VYNMFVQAGGIISSNIYRKDDSPKYRRGNRVLFGIAFVSLASLIVTKCYYVWRNKTRERIWNAMSVDEQNDYRKNTTDKG
NKRLDFRFVH

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features