MIA_00984_1

Protein

Length

1,084 amino acids

Protein function

EGGNOG:	0PFD7	FG04919.1	P-type ATPase
SGD closest match:	S000002445	ENA5	Sodium transport ATPase 5
CGD closest match:	CAL0000188030	ENA2	Na(+)-exporting P-type ATPase

Protein alignments

	%id	Aln length
MCA_01736_1	78.07%	1076	MCA_01736_1
A0A0J9XB98_GEOCN	72.72%	1074	Similar to Saccharomyces cerevisiae YDR039C ENA2 P-type ATPase sodium pump OS=Geotrichum candidum GN=BN980_GECA06s04729g PE=3 SV=1
A0A1E3PDB7_9ASCO	65.66%	1060	p-type ATPase sodium pump OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84130 PE=3 SV=1
Q6CI72_YARLI	65.24%	1076	YALI0A01023p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A01023g PE=3 SV=1
A0A1E4TKW8_9ASCO	60.29%	1103	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30559 PE=3 SV=1
A0A167FR63_9ASCO	60.95%	1050	Putative Na(+)-exporting P-type ATPase ENA5 OS=Sugiyamaella lignohabitans GN=ENA5 PE=3 SV=1
UniRef50_K0KJC4	61.00%	1036	Na+-exporting ATPase n=70 Tax=Ascomycota TaxID=4890 RepID=K0KJC4_WICCF
Q5ABA1_CANAL	58.87%	1065	Na(+)-exporting P-type ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ENA2 PE=3 SV=1
A0A060TAG6_BLAAD	58.48%	1038	ARAD1D26796p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26796g PE=3 SV=1
ATN5_YEAST	55.67%	1076	Sodium transport ATPase 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ENA5 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0037

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IID (IPR006414)

Domains and repeats

Domain
39 - 113
Cation-transporting P-type ATPase, N-terminal (IPR004014)
150 - 258
P-type ATPase, A domain (IPR008250)
357 - 645
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
589 - 859
HAD-like domain (IPR023214)
Domain
40 - 151
P-type ATPase, transmembrane domain (IPR023298)
299 - 390
P-type ATPase, transmembrane domain (IPR023298)
800 - 1,047
P-type ATPase, transmembrane domain (IPR023298)
Domain
841 - 1,041
Cation-transporting P-type ATPase, C-terminal (IPR006068)

1 100 200 300 400 500 600 700 800 900 1000 1084

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  286 - 417
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  724 - 831
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR006414

P-type ATPase, subfamily IID
1. cd02086 (P-type_ATP...)
  
  59 - 1,043
  
  CDD
  cd02086 (P-type_ATPase_Na_ENA)
2. TIGR01523
  
  41 - 1,048
  
  TIGRFAMs
  TIGR01523 (TIGR01523)
IPR004014

Cation-transporting P-type ATPase, N-terminal
1. PF00690 (Cation_ATP...)
  
  41 - 108
  
  Pfam
  PF00690 (Cation_ATPase_N)
2. SM00831 (Cation_ATP...)
  
  39 - 113
  
  SMART
  SM00831 (Cation_ATPase_N_a_2)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  40 - 151
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  299 - 390
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  800 - 1,047
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  150 - 258
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  589 - 859
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  395 - 414
  
  SUPERFAMILY
  SSF56784 (HAD-like)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  403 - 642
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  357 - 645
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR006068

Cation-transporting P-type ATPase, C-terminal
1. PF00689 (Cation_ATP...)
  
  841 - 1,041
  
  Pfam
  PF00689 (Cation_ATPase_C)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  398 - 404
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

869 - 887

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

134 - 314

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

369 - 809

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,042 - 1,084

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 92

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

958 - 985

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.11...

654 - 1,055

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
G3DSA:2.70.15...

48 - 262

GENE3D
G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
NON_CYTOPLASM... (N...)

110 - 114

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,008 - 1,018

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

832 - 846

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

337 - 341

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

914 - 932

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

306 - 375

Pfam
PF00122 (E1-E2_ATPase)

148 - 266

Pfam
PF00122 (E1-E2_ATPase)
PF13246 (Cation_ATPase)

484 - 569

Pfam
PF13246 (Cation_ATPase)
PR00119 (CATATPASE)

396 - 410

PRINTS
PR00119 (CATATPASE)

774 - 786

PRINTS
PR00119 (CATATPASE)

198 - 212

PRINTS
PR00119 (CATATPASE)

638 - 649

PRINTS
PR00119 (CATATPASE)

660 - 670

PRINTS
PR00119 (CATATPASE)

750 - 769

PRINTS
PR00119 (CATATPASE)
TMhelix

810 - 832

TMHMM
TMhelix (TMhelix)

344 - 366

TMHMM
TMhelix (TMhelix)

312 - 334

TMHMM
TMhelix (TMhelix)

932 - 954

TMHMM
TMhelix (TMhelix)

114 - 133

TMHMM
TMhelix (TMhelix)

847 - 869

TMHMM
TMhelix (TMhelix)

890 - 912

TMHMM
TMhelix (TMhelix)

93 - 110

TMHMM
TMhelix (TMhelix)

1,017 - 1,039

TMHMM
TMhelix (TMhelix)

985 - 1,007

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

315 - 336

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

986 - 1,007

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

888 - 913

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

810 - 831

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

933 - 957

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

342 - 368

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

847 - 868

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

93 - 109

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,019 - 1,041

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

115 - 133

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

phosphorylation si...

398D

phosphorylation site
398D
CDD
cd02086 (P-type_ATPase_Na_ENA)
P-type ATPase sign...

398D

P-type ATPase signature motif
398D, 399K, 400T, 401G, 402T, 403L, 404T
CDD
cd02086 (P-type_ATPase_Na_ENA)

399K

P-type ATPase signature motif
398D, 399K, 400T, 401G, 402T, 403L, 404T
CDD
cd02086 (P-type_ATPase_Na_ENA)

400T

P-type ATPase signature motif
398D, 399K, 400T, 401G, 402T, 403L, 404T
CDD
cd02086 (P-type_ATPase_Na_ENA)

401G

P-type ATPase signature motif
398D, 399K, 400T, 401G, 402T, 403L, 404T
CDD
cd02086 (P-type_ATPase_Na_ENA)

402T

P-type ATPase signature motif
398D, 399K, 400T, 401G, 402T, 403L, 404T
CDD
cd02086 (P-type_ATPase_Na_ENA)

403L

P-type ATPase signature motif
398D, 399K, 400T, 401G, 402T, 403L, 404T
CDD
cd02086 (P-type_ATPase_Na_ENA)

404T

P-type ATPase signature motif
398D, 399K, 400T, 401G, 402T, 403L, 404T
CDD
cd02086 (P-type_ATPase_Na_ENA)
putative ATP bindi...

398D

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

399K

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

400T

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

533F

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

557K

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

558G

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

559A

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

607L

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

668T

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

669G

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

670D

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

727R

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

730P

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

733K

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

752D

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)

755N

putative ATP binding site
398D, 399K, 400T, 533F, 557K, 558G, 559A, 607L, 668T, 669G, 670D, 727R, 730P, 733K, 752D, 755N
CDD
cd02086 (P-type_ATPase_Na_ENA)
putative cation bi...

813H

putative cation binding site
813H, 817G, 818N, 820S, 821Q, 846E, 849W, 850V
CDD
cd02086 (P-type_ATPase_Na_ENA)

817G

putative cation binding site
813H, 817G, 818N, 820S, 821Q, 846E, 849W, 850V
CDD
cd02086 (P-type_ATPase_Na_ENA)

818N

putative cation binding site
813H, 817G, 818N, 820S, 821Q, 846E, 849W, 850V
CDD
cd02086 (P-type_ATPase_Na_ENA)

820S

putative cation binding site
813H, 817G, 818N, 820S, 821Q, 846E, 849W, 850V
CDD
cd02086 (P-type_ATPase_Na_ENA)

821Q

putative cation binding site
813H, 817G, 818N, 820S, 821Q, 846E, 849W, 850V
CDD
cd02086 (P-type_ATPase_Na_ENA)

846E

putative cation binding site
813H, 817G, 818N, 820S, 821Q, 846E, 849W, 850V
CDD
cd02086 (P-type_ATPase_Na_ENA)

849W

putative cation binding site
813H, 817G, 818N, 820S, 821Q, 846E, 849W, 850V
CDD
cd02086 (P-type_ATPase_Na_ENA)

850V

putative cation binding site
813H, 817G, 818N, 820S, 821Q, 846E, 849W, 850V
CDD
cd02086 (P-type_ATPase_Na_ENA)

Protein sequence

>MIA_00984_1
MNPEKKLPIVKIKSDAQSAYSISDHDGSNSPTIQNAKQAPWTLTIEQTAQEFKTSITQGLTDQEIETRLAKYGLNELDQG
EGVSILKVLMRQVCNAMVLVLVISMAISFGIKDWIAGGVIGGVIGINVFVGFIQEYNAEKTMESLRSLSSPTARVIRSGT
DETIPSVNVVPGDLIVVKVGDTVPADFRIVDSMNFETDEALLTGESLPVSKDQNTVFPTDCGVGDRINMAYSSSIVTKGR
ATGICTSTGMFTEIGVIAMSLRSQNKGFRPVKRDEFGKAHKRDYIGAFIGTVKDAIGAFLGVNVGTPLQRKLAQLAIFLF
GVAVVFAIVVMAAQKFKVNREVAVYAIAVALSMIPGSLVVVLTITMAVGTKVMVKRNVIVRKLDSLEALGIVSDICSDKT
GTLTQGKMVGRKVWIPSVGTYQVINSTEAFNPTAGQVTFSPNTPYQDSTEDDVHQPCPQPHPKHFTEWLSSASLANIANI
HCETDESGSNVWKANGDPTEIAIQVFAQRMDWQRTKWTDGDNPKFTHLAEYPFDSSIKRMSAIYRENATGHVCIFTKGAV
ERVLGCCSTWYGGSNPDENGVSTLTESDTQFILKNMDALAKQGLRVLSFSYKIYTGPKDINWKEADRNDIEKDLHFLGLI
GIYDPPRLESAGAVKMCHRAGISVHMLTGDHPGTAKSIAQEVGILPHNLYHYPEDVVKAMIMTAQQFDSLSDDEIDALPV
LPLVIARCAPQTKVRMIDALHRRKAFCAMTGDGVNDSPSLKRADVGIAMGISGSDVAKDASDIVLSDDNFASILNAVEEG
RRMAANIQKFVLHLLAGNVSQALFLLIGLAFQDDDGYSVFPLSPVEVLWVIMITSSFPAMGLGIEAAAPDIMDRPPANSK
AGIFTWEIIVDMICFGILIAIACIISFVVVVYGDGKGNLGENCNNKYTEPCLYVFRGRSTSFLTMTWCLLLLAWEVIDLR
RSVFAMHPDSETPYTQVFEDLWSNQFLFWSVVLGFATAPPLLYIPVINKIVFKHGPITWEWGVSVATVVLFFMGSEMYKW
FKRIYFRRKNNSEKNQDDLESATFSKYSSISKEPQEHLIKKSIQ

GO term prediction

Biological Process

GO:0006812 cation transport

Molecular Function

GO:0000166 nucleotide binding
GO:0019829 cation-transporting ATPase activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features