Protein

MIA_00903_1

Length
1,603 amino acids

Browser: contig01:2541285-2546097+

Protein function

EGGNOG:0PJ9TTSC2GTPase Activating Protein
CGD closest match:CAL0000194326TSC2Tsc2p

Protein alignments

%idAln lengthE-value
MCA_05539_140.984%17080.0MCA_05539_1
A0A060TEM2_BLAAD39.295%15320.0ARAD1D08910p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D08910g PE=4 SV=1
UniRef50_A0A060TEM239.295%15320.0ARAD1D08910p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060TEM2_BLAAD
A0A0J9X370_GEOCN37.508%16130.0Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s01517g PE=4 SV=1
A0A167D7B0_9ASCO44.029%9630.0Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_827 PE=4 SV=1
Q6C6R0_YARLI45.297%9250.0YALI0E07095p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E07095g PE=4 SV=1
A0A1E3PMR5_9ASCO41.876%8740.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69849 PE=4 SV=1
A0A1D8PMB6_CANAL29.223%15570.0Tsc2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TSC2 PE=4 SV=1
A0A1E4TIE1_9ASCO28.944%14960.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_29916 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6363

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1603

Detailed signature matches

  1. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  2. Domain IPR011989
    Armadillo-like helical
    1. G3DSA:1.25.10.10
  3. Domain IPR024584
    Tuberin, N-terminal
    1. PF11864 (DUF3384)
  4. Domain IPR018515
    Tuberin-type domain
    1. PF03542 (Tuberin)
  5. Domain IPR000331
    Rap GTPase activating protein domain
    1. SSF111347 (Rap/Ran-GAP)
    2. PS50085 (RAPGAP)
    3. PF02145 (Rap_GAP)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TRANSMEMBRANE (Tran...)
  4. mobidb-lite (disord...)

Protein sequence

>MIA_00903_1
MSRSYKSNTNVHSNQSNSNTSVLGNVIKFAKQVRNGLSQTGPQIQERPNIVGGAPDRSFQNVFEKLGPSNNAPDRITAAK
EISKSITDYSVSSIQEIWESARDMLSLTNSPECRRAGLELMIACIRQTPDDTDVRLINSSFYNDIVNSCNVQDFDLQLQA
MMFLTHNGTVVEDFFKSKESLPKVLDSWFRILSEETQKIREKVNTDSTILWGSSTEKNFLDFVKFTILIYQHNSLLFSTG
NTIDLLDRVNKTCQATSSEQDILVCLDLVLTIQQNSYIPLKSLPDLSETLCGIIACATTINQSREKAWCIIKAIYNGPLA
INMFNNFLQFVGNRSVKTTMNTRQGATIALRCIVEMSSEKNREFEFPLYEVLAAYRSSIDSESMRQNLEVITCLFSLISN
DFIRDKVFTFAIWTSPKISPFEIFYSIARSRSMQRSTAQLSNYFDRQSFTDRESILTRSESKMSKQYQVLERLQEIFNYL
ADIFEQDKFKGPREIIINFFADMVDLINSRCAILVINHFRKFSCCHPFTEHWRNNLRILLNGFYFDRSWNSEIRLLALDL
LCDIYKIAREICETEIQQMLIENIFKISDSEKDITLFSYLVDKFVDLAEETSPESIEIASKFLFCVFSIPAEDSSQTRRR
SITSLTSSYANDRISMTSANSVPNNASPQFSPIHDNRGDASTFQSQELLESYRPIVAVGFCKAFLAVFQYSSIKARRFYY
NLIVICQKSLSSNDAASFLEVARLLCRIRSTTEGYIYLSTPTNMDGLSASVGRNTILNPKIDKSTIMWWYPETPSYILDN
HLNKPSSTLKRHSDETFEIQRLKANEYEIDIALWFNEIIGIIENGAHWEIYSFVWAHFGPQLSNLELFRTSGSDIHRLRK
ILCDQLLNTKLPNVKYPKDVTKFEILISLVRTISSLIGYHDMFTKQDGEEIVKCLVSGLSSWEQTAVSCIHALVVCCHEL
PLPIKKYLGQIFTKFQSKISNTNTSPHILEFLLSLSRLPTLVDNFTQDEYKRVFGMAFQYIRDAYTLSQQAESVNNTDPR
SLSPVSSPIGGPVSTPTISNNKQLSVYLLSLAYNVVATWFLTLRITNRKYLAKFIIRNLILAAGTKNDIDPQGMAYIDLI
SRFSYSDLDLTIQTTISLPSLEGSSNRQAKQWIYGNSIVSIDTDEQTGESYIVIRRPTGTTMLTLKPDEKIIPSWLEEAV
LKRNDKSLNIDRIADDIPIAFTPNYFFLQVMYSTDLNTSVKPLQLPNDVTTSRAISSFDRTPVVDFHKIGILYIGPNQQD
EKEILSNPVGSPSYRRFLENLGKLVRLKDNKKVYSGGLDTTNDIDGKYAYVWSDKVTQMIFHITTLMPAPANPSDTSYSS
KKRHIGNDFVNIYFDESELPFKFDIIKSQFNFINIVITPVSVNFSKHKVFTRSDETPVSPILQPSRPRPGEEHAVKPKVY
YKVRAYCKPGVPAIFAACHLKIVSEDSLAGFVRNLALISSKFATVWNNAGEYRSNWQYRLEQINTLRDKVVNDINKSTHN
QPAQANNKGHQRGESVDNKDIEVGQSFLDQLTAGGSGLGGLGSINEGGESMDKRDSSGQFTMEIQDGDDFPLLKSLDFTS
FTS

GO term prediction

Biological Process

GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction

Molecular Function

GO:0005096 GTPase activator activity
GO:0005488 binding

Cellular Component

None predicted.