MIA_00828_1

Protein

Length

649 amino acids

Protein function

EGGNOG:	0QE2Z		transporter
SGD closest match:	S000001039	ARN2	Siderophore iron transporter ARN2
CGD closest match:	CAL0000196424	SIT1	Siderophore transporter

Protein alignments

	%id	Aln length	E-value
MCA_05025_1	70.696%	546	0.0	MCA_05025_1
A0A0J9XBS7_GEOCN	50.804%	622	0.0	Similar to Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter OS=Geotrichum candidum GN=BN980_GECA07s02375g PE=4 SV=1
UniRef50_A0A0J9X4Q5	47.867%	633	0.0	Similar to Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X4Q5_GEOCN
Q6C0X7_YARLI	30.855%	538	1.95e-60	YALI0F20922p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20922g PE=4 SV=1
A0A060SYI4_BLAAD	30.541%	573	2.61e-58	ARAD1A16852p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A16852g PE=4 SV=1
Q5A2T6_CANAL	28.331%	593	2.40e-43	Siderophore transporter OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SIT1 PE=4 SV=1
A0A1E3PN76_9ASCO	26.200%	500	1.68e-42	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21345 PE=4 SV=1
A0A1E4TLQ4_9ASCO	27.556%	577	3.52e-42	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30763 PE=4 SV=1
A0A167ED34_9ASCO	27.984%	511	1.94e-40	Sit1p OS=Sugiyamaella lignohabitans GN=SIT1 PE=4 SV=1
ARN2_YEAST	24.958%	597	3.61e-39	Siderophore iron transporter ARN2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARN2 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0036

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
71 - 609
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 649

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  90 - 520
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  85 - 602
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  571 - 609
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  71 - 286
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  353 - 530
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  89 - 531
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

434 - 437

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

600 - 649

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

197 - 207

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

263 - 299

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

353 - 371

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

139 - 149

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

482 - 501

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 80

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

357 - 616

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

75 - 276

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

230 - 240

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

458 - 462

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

322 - 332

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

100 - 118

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

398 - 416

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

168 - 172

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

529 - 579

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

174 - 196

TMHMM
TMhelix (TMhelix)

333 - 352

TMHMM
TMhelix (TMhelix)

581 - 603

TMHMM
TMhelix (TMhelix)

145 - 167

TMHMM
TMhelix (TMhelix)

372 - 394

TMHMM
TMhelix (TMhelix)

82 - 104

TMHMM
TMhelix (TMhelix)

438 - 460

TMHMM
TMhelix (TMhelix)

502 - 524

TMHMM
TMhelix (TMhelix)

240 - 262

TMHMM
TMhelix (TMhelix)

296 - 318

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

81 - 99

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

208 - 229

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

300 - 321

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

333 - 352

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

502 - 528

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

119 - 138

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

417 - 433

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

372 - 397

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

173 - 196

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

241 - 262

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

580 - 599

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

463 - 481

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

150 - 167

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

438 - 457

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 61

MobiDB Lite
mobidb-lite (disorder_prediction)

628 - 649

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

100K

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

103S

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

104G

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

105T

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

107T

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

108P

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

124G

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

127E

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

128R

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

131G

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

135Y

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

136P

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

138V

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

139A

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

185D

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

186V

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

189G

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

190I

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

193Q

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

194I

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

197S

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

209L

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

210S

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

213E

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

214A

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

220T

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

383F

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

386Y

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

387A

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

390T

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

391S

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

394P

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

408S

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

412D

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

416R

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

419F

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

423S

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

479G

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

482R

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

483G

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

486Q

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

490Q

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

491V

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

494Q

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

505V

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

506T

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

509F

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

510F

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

513M

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

514S

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

517G

putative substrate translocation pore
100K, 103S, 104G, 105T, 107T, 108P, 124G, 127E, 128R, 131G, 135Y, 136P, 138V, 139A, 185D, 186V, 189G, 190I, 193Q, 194I, 197S, 209L, 210S, 213E, 214A, 220T, 383F, 386Y, 387A, 390T, 391S, 394P, 408S, 412D, 416R, 419F, 423S, 479G, 482R, 483G, 486Q, 490Q, 491V, 494Q, 505V, 506T, 509F, 510F, 513M, 514S, 517G
CDD
cd06174 (MFS)

Protein sequence

>MIA_00828_1
MKTPESDQPKEDPANGVPEKDLAEISIQSSSLNEVNSKSISETTSNEANEIKKDSESDSDVSLQPGVQMVELLRHAWPKK
LLYIAYGSIVLSSLIVSFSKYASGTYTPFVTSDFNTHSLLSTAGVIERIAGIVSYPVVAKTSDFFGRADGFALAFTIIIT
SYVMFAACQNINTYVAASVFDSIGDVAYGIMVQIFISDTSSLANRGFLLSLPEAITTIPTLYLGSIVAQSMLDHSTWRWG
YGMWAPILFFIAIPLVGIQWYLQRKATRSGVDKKKIRIFENFKEEDTIWKKIYRVLWIELDLGGALLLIAALSLILVPVT
LTGKAYSYRWRDASFISMFVVGFVILGAFLYWDTKIAKKPFIPYRMIKHWTVIAALLMNAFDFCAYAVYTSFFPSFLLVG
AGYSAGQSTRVDNSLRVSFQISSVVIGLFMKYFQRSKIFVFIGVPLCLLGQGLMIYLTNINGTHVGSEVAFVTAKVLYGV
GRGFYQTSLQVTVQSIVSKQDVAVVTALFFAAMSLGGAIGVSIGGGFWNNYLPERLTEFLPEEAQKNATSIFKSINVARA
TKGATREAVNTAYRVTLQKLAIMGTCFLVPLLFLMFFIANTHLDTAEEEQKYEEEQKEKVKTHVIMHHEENSPEEGSVVK
NSVVIQEKS

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

Filter view on

Entry type

Status

Per-residue features