Protein

MIA_00744_1

Length
862 amino acids

Browser: contig01:2114302-2117052+

Protein function

EGGNOG:0PH9AHULAE3 ubiquitin-protein ligase
SGD closest match:S000000927RSP5E3 ubiquitin-protein ligase RSP5
CGD closest match:CAL0000178037RSP5E3 ubiquitin-protein ligase

Protein alignments

%idAln lengthE-value
MCA_06117_187.745%6120.0MCA_06117_1
A0A0J9XBS5_GEOCN85.458%6120.0E3 ubiquitin-protein ligase OS=Geotrichum candidum GN=BN980_GECA09s02177g PE=4 SV=1
A0A167D731_9ASCO81.715%6180.0E3 ubiquitin-protein ligase OS=Sugiyamaella lignohabitans GN=RSP5 PE=4 SV=1
UniRef50_A0A167D73181.715%6180.0E3 ubiquitin-protein ligase n=76 Tax=Dikarya TaxID=451864 RepID=A0A167D731_9ASCO
A0A060T4D3_BLAAD81.373%6120.0E3 ubiquitin-protein ligase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C44044g PE=4 SV=1
A0A1E4TDD7_9ASCO78.125%6080.0E3 ubiquitin-protein ligase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_144090 PE=4 SV=1
Q6C5H0_YARLI78.261%6210.0E3 ubiquitin-protein ligase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E18117g PE=4 SV=1
Q59Y21_CANAL76.974%6080.0E3 ubiquitin-protein ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RSP5 PE=4 SV=1
RSP5_YEAST73.934%6100.0E3 ubiquitin-protein ligase RSP5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RSP5 PE=1 SV=1
A0A1E3PJN2_9ASCO73.849%6080.0E3 ubiquitin-protein ligase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83209 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1954
Predicted cleavage: 13

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 862

Detailed signature matches

  1. Family IPR024928
    E3 ubiquitin-protein ligase, SMURF1 type
    1. PIRSF001569 (E3_ub_...)
  2. Domain IPR000008
    C2 domain
    1. PF00168 (C2)
    2. SM00239 (C2_3c)
    3. PS50004 (C2)
    4. SSF49562 (C2 domain...)
    5. G3DSA:2.60.40...
  3. Domain IPR001202
    WW domain
    1. PS01159 (WW_DOMAIN_1)
    2. SM00456 (ww_5)
    3. SSF51045 (WW domain)
    4. PF00397 (WW)
    5. PS50020 (WW_DOMAIN_2)
    6. cd00201 (WW)
  4. Domain IPR000569
    HECT domain
    1. PF00632 (HECT)
    2. cd00078 (HECTc)
    3. SSF56204 (Hect, E3 ...)
    4. SM00119 (hect_3)
    5. PS50237 (HECT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.20.70.10
  2. G3DSA:3.30.24...
  3. G3DSA:3.90.17...
  4. cd08382 (C2_Smurf-like)
  5. mobidb-lite (disord...)

Residue annotation

  1. putative Ca2+ bind...
  2. binding pocket cd0...
  3. binding pocket cd0...
  4. binding pocket cd0...
  5. catalytic cleft cd...
  6. E2 interaction sit...

Protein sequence

>MIA_00744_1
MPGPARVFRLRVTTITITDFFFSVIAADALAKRDVFRLPDPFAVITVDGSQTKSTQAIKKTLSPYWHKQFDVDVTENSII
AVQIFDQKKFKKKDQGFLGVINIRVGDVIDLHAGGDEMITRDLKKSNDNLSVTGKLILNLSTNVAAPIATERAAPASTSS
SSSNAPAPVASPASSSKNGSYSGPASSSNRGSSSNASAFAMAASESAAFSQQQHTLADNMNQLSLGNGHPSSSRFSESSA
GTSTPTSATNNRPVYSSFEDQHGRLPPGWERKTDNLGRTYYVDHNTRTTTWTRPSSDINESDQRVARQTATELERQRHHN
RMLPEDSRTTSPSPGTESSQRPASPQSQQQRAQSPYASAQNVSSTANAVQMLNTGATTAGLGELPVGWEQRVTPEGRPYF
VDHNTRTTTWVDPRRQQYIRIYGNASAQGNIQQQPVSQLGPLPSGWEMRLTSTARVYFVDHNTKTTTWDDPRLPSSLDQN
VPQYKRDFRRKLIYFRSQPALRATAGQCHIKVRRGHIFEDSYQEIMRQTPADLKKRLMIKFEGEEGLDYGGVSREFFFLL
SHEMFNPFYCLFEYSAHDNYTLQINPHSGVNPEHLNYFKFIGRVVGLAIFHRRFLDGFFIAAFYKMILRKKVVLSDMEGV
DADFYRNLEWTLNNDIDGILDLTFSVEDDLFGKIVTVDLKPGGRDLPVTNENKREYVELVTEWKISRRVEEQFRAFMVGF
NELIPQELINVFDERELELLIGGISEIDVDDWKKHTDYRGYSENDEVIQWFWKCVRSWDSEQKSRLLQFTTGTSRIPVNG
FKDLQGSDGPRRFTIEKAGEPDQLPKSHTCFNRVDLPPYKNYETLQQKLLLAVEETVGFGQE

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process

Molecular Function

GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0061630 ubiquitin protein ligase activity

Cellular Component

None predicted.