Protein

MIA_00575_1

Length
814 amino acids

Browser: contig01:1652081-1654599+

Protein function

EGGNOG:0PFVPACO2aconitate hydratase
SGD closest match:S000003736ACO2Homocitrate dehydratase, mitochondrial
CGD closest match:CAL0000193227ACO2Aconitate hydratase, mitochondrial

Protein alignments

%idAln lengthE-value
MCA_05791_187.848%7900.0MCA_05791_1
A0A0J9XJZ4_GEOCN85.375%8000.0Aconitate hydratase, mitochondrial OS=Geotrichum candidum GN=BN980_GECA27s00175g PE=3 SV=1
A0A1D8PT27_CANAL75.558%8060.0Aconitate hydratase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ACO2 PE=3 SV=1
A0A060T4C0_BLAAD74.005%8040.0Aconitate hydratase, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C43692g PE=3 SV=1
Q6C5V2_YARLI71.871%8070.0Aconitate hydratase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E14949g PE=3 SV=1
ACON2_YEAST71.970%7920.0Homocitrate dehydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACO2 PE=1 SV=1
A0A1E3PNQ1_9ASCO72.265%7860.0Aconitate hydratase, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45198 PE=3 SV=1
A0A167FHP5_9ASCO76.956%7030.0Aconitate hydratase, mitochondrial OS=Sugiyamaella lignohabitans GN=ACO2 PE=3 SV=1
UniRef50_A0A167FHP576.956%7030.0Aconitate hydratase, mitochondrial n=36 Tax=cellular organisms TaxID=131567 RepID=A0A167FHP5_9ASCO
A0A1E4TL49_9ASCO70.000%7900.0Aconitate hydratase, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_86901 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9806
Predicted cleavage: 30

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 814

Detailed signature matches

  1. Family IPR006248
    Aconitase, mitochondrial-like
    1. TIGR01340
  2. Domain IPR015931
    Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
    1. G3DSA:3.30.49...
  3. Domain IPR001030
    Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
    1. PR00415 (ACONITASE)
    2. SSF53732 (Aconitase...)
    3. PF00330 (Aconitase)
  4. Domain IPR015932
    Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
    1. G3DSA:3.40.10...
  5. Domain IPR015928
    Aconitase/3-isopropylmalate dehydratase, swivel
    1. G3DSA:3.20.19.10
    2. SSF52016 (LeuD/IlvD...)
  6. Domain IPR000573
    Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
    1. PF00694 (Aconitase_C)
  7. SITE IPR018136
    Aconitase family, 4Fe-4S cluster binding site
    1. PS00450 (ACONITASE_1)
    2. PS01244 (ACONITASE_2)

Protein sequence

>MIA_00575_1
MSMLRASRASILRSQKSLNRSLATAASSDFFSVPQEFKSRTPPYEALLNRLSTVKSILNDQPLTLAEKILYSHLVDPAES
LTSSNTKDIRGQAYLKLNPDRVAMQDASAQMALLQFMTCGMPSTAVPASIHCDHLIVGHDGADQDLPRSIAANKEVFDFL
QSCGKKYGIQFWGPGSGIIHQIVLENFSVPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKL
TGQLSGWSAPKDVITHLAGLLTVRGGTGSIIEYFGEGVETLSCTGMATICNMGAELGATTSTFPYTPSMQRYLTATHRAP
IADVAQRVNDKFGFLRADEGAEYDQVVEIDLSSLEPHVNGPFTPDLATPISKFAETAKEKEWPSEISAGLIGSCTNSSYQ
DMTRAASIIAEATKNGLKPKIPFFVTPGSEQIRATIERDGLTKTFEDAGAKILANACGPCIGQWDRSTESLYADHKEEKT
PKNSIFTSFNRNFRARNDGNPNTFNFLTSPEIVTAMIYAGSTNFNPLKDTIVTEGGKEFKFSPPPPAKELPDAADGGFTK
GPRSQYYPETDPKPVAETEVVVSPTSERLSLLEPFEPFDGKEISANVLLKVKGKCTTDHISAAGVWLKYKGHLENISYNT
LIGAQNEENGKVNVVEDFDGKEMSIPDLMIKWKEEGRPWLVVAEHNYGEGSAREHAALSPRFLGGKIILVKSFARIHETN
LKKQGVLPLTFADEADYDRISSTDKIETLDLLDMLDKDGNNGGELKLRVTKNDGTTFDITAKHTMSKDQVNFFKAGSAIN
YIGNLRKAELARKQ

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process

Molecular Function

GO:0003994 aconitate hydratase activity
GO:0051539 4 iron, 4 sulfur cluster binding

Cellular Component

None predicted.