Protein

MIA_00491_1

Length
986 amino acids

Browser: contig01:1417266-1420227-

Protein function

EGGNOG:0PHFHCCR4Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. CCR4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth
SGD closest match:S000000019CCR4Glucose-repressible alcohol dehydrogenase transcriptional effector
CGD closest match:CAL0000194050CCR4Glucose-repressible alcohol dehydrogenase transcriptional effector

Protein alignments

%idAln lengthE-value
MCA_05368_159.328%5950.0MCA_05368_1
A0A0J9XF67_GEOCN49.215%5730.0Similar to Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression OS=Geotrichum candidum GN=BN980_GECA12s04036g PE=4 SV=1
UniRef50_A0A0J9XF6749.215%5730.0Similar to Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XF67_GEOCN
A0A060TCH9_BLAAD47.203%5720.0ARAD1D36256p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D36256g PE=4 SV=1
A0A1E3PFL5_9ASCO43.124%5891.03e-162Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83730 PE=4 SV=1
CCR4_YARLI43.784%5551.49e-162Glucose-repressible alcohol dehydrogenase transcriptional effector OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CCR4 PE=3 SV=1
CCR4_CANAL42.780%5541.53e-156Glucose-repressible alcohol dehydrogenase transcriptional effector OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CCR4 PE=3 SV=2
CCR4_YEAST41.651%5332.15e-135Glucose-repressible alcohol dehydrogenase transcriptional effector OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCR4 PE=1 SV=2
A0A1E4TJP4_9ASCO39.626%5356.40e-125Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20833 PE=4 SV=1
A0A167E6Z2_9ASCO46.429%3641.45e-109CCR4-NOT core exoribonuclease subunit CCR4 OS=Sugiyamaella lignohabitans GN=CCR4 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0006
Predicted cleavage: 156

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Repeat
  4. Repeat
1 100 200 300 400 500 600 700 800 900 986

Detailed signature matches

  1. Domain IPR032675
    Leucine-rich repeat domain, L domain-like
    1. SSF52058 (L domain-...)
    2. G3DSA:3.80.10.10
  2. Domain IPR005135
    Endonuclease/exonuclease/phosphatase
    1. SSF56219 (DNase I-like)
    2. PF03372 (Exo_endo_phos)
    3. G3DSA:3.60.10.10
  3. Repeat IPR001611
    Leucine-rich repeat
    1. PS51450 (LRR)
  4. Repeat IPR003591
    Leucine-rich repeat, typical subtype
    1. SM00369 (LRR_typ_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. SM00364 (LRR_bac_2)
  3. mobidb-lite (disord...)

Protein sequence

>MIA_00491_1
MNSSQSANNYHQAMPDASPLQQLQMGGPINAQAMYPLQFQKSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
QQQQQQQQQQQQQQQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQPQQHSSQLYFSQQQQQNVNLANLQLRQAAGLG
VATSSPVIATAPSVTSPNSTTLSTTTTAATNPTGKSSEQQPQSLLAPEPLDPALANSQFWQQQTQLAIASSKATQPHTYA
RNAALASRASHAPQGSQVQVPLTIYEQAMQFVAQNFHAHHFAAQAAHAAHATGPSSSSSSTNNTASGNTIATNPNTQSTV
NSNNGNNNSSSSGTNPTAPTSNSGNSVTTAATSASVAAGSTPTASTTTTSTTVTSTTTTTTSSANESSSSGTGAPSTPSK
SSRMSASLTGIHHMNQRKEQMEDERQRQINEQVKKQFWTAIDLSGLSLPKISPKLFNYDFLQKLYLAHNNLEYLPSSIKQ
LSQLKILDVSSNRLTSLPDELGLLYHLRYLFFFDNQIQQLPLQFGSLFQLDFMGIEGNPLDNETRTIMATEGTRAVIFNL
RDKAPRDIDPPPREWRVFEGNVVSVGTLPTSSSPKNSILNSFKDTESNNNNHNNSSNALATSTNTSLESFTVLSYNILCD
TYATPSMYSYTPSWAIEWSYRSKHLLHELEYYSPDIICLQEVDRYNYEALFAPTMRERGYEAHYMQKTRSKHSDVDETRV
DGCATFYRSDKFKLIERAGVEFAQAARENEDLRKGQDTFNRFLNRDNVAMILVLEHIASGRLLVATNTHLHWDPAYKDVK
VMQIVILLEELAKVVKRYAGSGRESNSSASNSSKRHSDIKNVPAIICGDFNSTADSGVCSLLLSGHIRDHEDLAGRSYGR
YSSEGTSHDFSFKSSYEGLKDELKFTNFTPNFVEVIDYIFFADQALEVKGALGPMDTAYSSTHVAIPDASHPSDHIPIMA
EFAFKKLREKTQSHPPVNFSSMSRKT

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding

Cellular Component

None predicted.