Protein
MIA_00489_1
Length
1,079 amino acids
Browser: contig01:1411603-1414843-
Protein function
| EGGNOG: | 0PHFH | CCR4 | Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. CCR4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth |
|---|---|---|---|
| SGD closest match: | S000000019 | CCR4 | Glucose-repressible alcohol dehydrogenase transcriptional effector |
| CGD closest match: | CAL0000194050 | CCR4 | Glucose-repressible alcohol dehydrogenase transcriptional effector |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_01389_1 | 42.466% | 438 | 5.17e-88 | MCA_01389_1 |
| CCR4_YARLI | 27.273% | 374 | 2.05e-25 | Glucose-repressible alcohol dehydrogenase transcriptional effector OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CCR4 PE=3 SV=1 |
| UniRef50_Q6CEJ6 | 27.273% | 374 | 4.74e-22 | Glucose-repressible alcohol dehydrogenase transcriptional effector n=2 Tax=Yarrowia lipolytica TaxID=4952 RepID=CCR4_YARLI |
| A0A167E6Z2_9ASCO | 28.049% | 328 | 9.38e-24 | CCR4-NOT core exoribonuclease subunit CCR4 OS=Sugiyamaella lignohabitans GN=CCR4 PE=4 SV=1 |
| A0A0J9XF67_GEOCN | 27.682% | 289 | 1.39e-22 | Similar to Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression OS=Geotrichum candidum GN=BN980_GECA12s04036g PE=4 SV=1 |
| A0A1E3PGL9_9ASCO | 27.273% | 319 | 7.06e-21 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52099 PE=4 SV=1 |
| A0A060TCH9_BLAAD | 24.224% | 322 | 4.31e-17 | ARAD1D36256p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D36256g PE=4 SV=1 |
| CCR4_CANAL | 23.397% | 312 | 1.03e-16 | Glucose-repressible alcohol dehydrogenase transcriptional effector OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CCR4 PE=3 SV=2 |
| CCR4_YEAST | 23.659% | 317 | 1.01e-13 | Glucose-repressible alcohol dehydrogenase transcriptional effector OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCR4 PE=1 SV=2 |
| A0A1E4TJP4_9ASCO | 27.149% | 221 | 1.43e-11 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20833 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0409
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
100
200
300
400
500
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700
800
900
1000
1079
Detailed signature matches
no IPR
Unintegrated signatures
-
mobidb-lite (disord...)
Protein sequence
>MIA_00489_1 MKIRNIFKKKQENSGSPVVIIDSSSYQSPSPESSTSPFQDDSDTLASFSARSSGSDSATSSSSTAATVTSVDHQKASLSS PPHVVSHRPSSSVCYAQVQHHLPATSLPSTLPSASTPSSLPPLQMPPIPPSTHHGTPISTTPSARPLSLQPQQLPRQSSS SASSSSASSSVSSNSAHSSQFSAPTSFASTNPPSPFKTSQQTNASVITTSGHNDHPLPQSSNPFSNSYEIPLQQPQPTFP IVPSLLPINIHDPPKQQQQQQPQSQTNSNSKSFLAFPKSQYLRNSRAGRHSLETDRPASATTSNSASANTLNSIPANTTH SVASVPHRTTSPPNTSSNRTSKYFFKSKKTDVLSSAHYNTSSNQPQQQQNQQHSQATFSSISAHIKKRASTFGPDLISRA QGVTSGVTRTTASSSSVSAAPAPAAAAGFNTLSSFSATSSTFSPSAGSAGASSLLSTSIDKSDKSDPTSDSWPPLRPWVP VNETLYNDYAASRLSHHPLTPNGDEEGTIIHKLQGFSVMSYNILSSLYTNRLENTIARKVGTSSSFSSSPSSLASQQAMR SRRERMALIMKEIKYYTPDILCLQEVDAQEYYGQMHYDLADYDSIYAPKHSHYTSGGNRPHSMLLSSSSSPSHSSGGGPG LGSTSIQPLVGSAAKNSLPIEGPAIFYKMDRFRLLEKRIFNYADLTLYYKSASAASKPETETLVDEAGLEAFAAERDVRE RVAGRSNVGIVAVLRHVPSGQIIIVANTQLVPDAKMPPTKLGSTIASTTSNSLADVRMVQAALCLEQIEYFTLKYTSAAP RSSDDNGNKVPVVLCGDLNSAATSGVYDLLAARGGPVSKLNDWQGRSYARFTDGLHPWHTGERLGLRSSYLVWGEDELVK KKKKKNPIVVATPPPPSPLLATEIHLMSNNPFSSYVTPSPTPPPVLPLSAPIEVVEKEEEDNSPTTTIHPKRRHILPYTK MSTAAGEGTLSDYIWYSTSTLAVAEVLGPDPNQRKRLIEEGEDNTDEYVWNDKRVNSTTAGSGSNGNNGNNYTNKTETVK GKGHETKHIQQERLAQGPTTYPSDHVCLLTRFEFKNQQF
GO term prediction
Biological Process
None predicted.
Molecular Function
None predicted.
Cellular Component
None predicted.