MIA_00351_1

Protein

Length

1,086 amino acids

Protein function

EGGNOG:	0PFD7	FG04919.1	P-type ATPase
SGD closest match:	S000002446	ENA2	Sodium transport ATPase 2
CGD closest match:	CAL0000188030	ENA2	Na(+)-exporting P-type ATPase

Protein alignments

	%id	Aln length
MCA_01736_1	83.178%	1070	MCA_01736_1
A0A0J9XB98_GEOCN	74.549%	1053	Similar to Saccharomyces cerevisiae YDR039C ENA2 P-type ATPase sodium pump OS=Geotrichum candidum GN=BN980_GECA06s04729g PE=3 SV=1
A0A1E3PDB7_9ASCO	66.323%	1066	p-type ATPase sodium pump OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84130 PE=3 SV=1
Q6CI72_YARLI	66.448%	1067	YALI0A01023p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A01023g PE=3 SV=1
A0A1E4TKW8_9ASCO	62.147%	1062	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30559 PE=3 SV=1
UniRef50_K0KJC4	62.584%	1045	Na+-exporting ATPase n=70 Tax=Ascomycota TaxID=4890 RepID=K0KJC4_WICCF
A0A167FR63_9ASCO	60.266%	1052	Putative Na(+)-exporting P-type ATPase ENA5 OS=Sugiyamaella lignohabitans GN=ENA5 PE=3 SV=1
Q5ABA1_CANAL	59.601%	1052	Na(+)-exporting P-type ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ENA2 PE=3 SV=1
A0A060TAG6_BLAAD	59.538%	1038	ARAD1D26796p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26796g PE=3 SV=1
ATN2_YEAST	57.208%	1096	Sodium transport ATPase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ENA2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0049

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IID (IPR006414)

Domains and repeats

Domain
34 - 108
Cation-transporting P-type ATPase, N-terminal (IPR004014)
145 - 253
P-type ATPase, A domain (IPR008250)
349 - 854
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
Domain
35 - 146
P-type ATPase, transmembrane domain (IPR023298)
294 - 385
P-type ATPase, transmembrane domain (IPR023298)
795 - 1,044
P-type ATPase, transmembrane domain (IPR023298)
Domain
836 - 1,038
Cation-transporting P-type ATPase, C-terminal (IPR006068)

1 100 200 300 400 500 600 700 800 900 1000 1086

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  719 - 826
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  298 - 412
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR006414

P-type ATPase, subfamily IID
1. cd02086 (P-type_ATP...)
  
  54 - 1,040
  
  CDD
  cd02086 (P-type_ATPase_Na_ENA)
2. TIGR01523
  
  33 - 1,045
  
  TIGRFAMs
  TIGR01523 (TIGR01523)
IPR004014

Cation-transporting P-type ATPase, N-terminal
1. PF00690 (Cation_ATP...)
  
  36 - 103
  
  Pfam
  PF00690 (Cation_ATPase_N)
2. SM00831 (Cation_ATP...)
  
  34 - 108
  
  SMART
  SM00831 (Cation_ATPase_N_a_2)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  795 - 1,044
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  35 - 146
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  294 - 385
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  145 - 253
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  584 - 854
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  390 - 409
  
  SUPERFAMILY
  SSF56784 (HAD-like)
2. G3DSA:3.40.50...
  
  640 - 766
  
  GENE3D
  G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  398 - 637
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  349 - 639
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR006068

Cation-transporting P-type ATPase, C-terminal
1. PF00689 (Cation_ATP...)
  
  836 - 1,038
  
  Pfam
  PF00689 (Cation_ATPase_C)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  393 - 399
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

864 - 882

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

955 - 982

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

129 - 309

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

364 - 804

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 82

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,039 - 1,086

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.11...

767 - 1,044

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
G3DSA:2.70.15...

43 - 257

GENE3D
G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
NON_CYTOPLASM... (N...)

827 - 841

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

332 - 336

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,005 - 1,015

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

908 - 935

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

104 - 108

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

143 - 261

Pfam
PF00122 (E1-E2_ATPase)
PF00702 (Hydrolase)

390 - 759

Pfam
PF00702 (Hydrolase)
PR00119 (CATATPASE)

655 - 665

PRINTS
PR00119 (CATATPASE)

391 - 405

PRINTS
PR00119 (CATATPASE)

769 - 781

PRINTS
PR00119 (CATATPASE)

193 - 207

PRINTS
PR00119 (CATATPASE)

633 - 644

PRINTS
PR00119 (CATATPASE)

745 - 764

PRINTS
PR00119 (CATATPASE)
TMhelix

888 - 907

TMHMM
TMhelix (TMhelix)

337 - 359

TMHMM
TMhelix (TMhelix)

83 - 105

TMHMM
TMhelix (TMhelix)

1,015 - 1,037

TMHMM
TMhelix (TMhelix)

109 - 128

TMHMM
TMhelix (TMhelix)

983 - 1,005

TMHMM
TMhelix (TMhelix)

805 - 827

TMHMM
TMhelix (TMhelix)

937 - 954

TMHMM
TMhelix (TMhelix)

310 - 327

TMHMM
TMhelix (TMhelix)

842 - 859

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

983 - 1,004

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

842 - 863

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

883 - 907

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

310 - 331

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,016 - 1,038

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

109 - 128

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

337 - 363

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

805 - 826

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

936 - 954

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

83 - 103

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

phosphorylation si...

393D

phosphorylation site
393D
CDD
cd02086 (P-type_ATPase_Na_ENA)
P-type ATPase sign...

393D

P-type ATPase signature motif
393D, 394K, 395T, 396G, 397T, 398L, 399T
CDD
cd02086 (P-type_ATPase_Na_ENA)

394K

P-type ATPase signature motif
393D, 394K, 395T, 396G, 397T, 398L, 399T
CDD
cd02086 (P-type_ATPase_Na_ENA)

395T

P-type ATPase signature motif
393D, 394K, 395T, 396G, 397T, 398L, 399T
CDD
cd02086 (P-type_ATPase_Na_ENA)

396G

P-type ATPase signature motif
393D, 394K, 395T, 396G, 397T, 398L, 399T
CDD
cd02086 (P-type_ATPase_Na_ENA)

397T

P-type ATPase signature motif
393D, 394K, 395T, 396G, 397T, 398L, 399T
CDD
cd02086 (P-type_ATPase_Na_ENA)

398L

P-type ATPase signature motif
393D, 394K, 395T, 396G, 397T, 398L, 399T
CDD
cd02086 (P-type_ATPase_Na_ENA)

399T

P-type ATPase signature motif
393D, 394K, 395T, 396G, 397T, 398L, 399T
CDD
cd02086 (P-type_ATPase_Na_ENA)
putative ATP bindi...

393D

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

394K

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

395T

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

528F

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

552K

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

553G

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

554A

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

602L

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

663T

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

664G

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

665D

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

722R

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

725P

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

728K

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

747D

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)

750N

putative ATP binding site
393D, 394K, 395T, 528F, 552K, 553G, 554A, 602L, 663T, 664G, 665D, 722R, 725P, 728K, 747D, 750N
CDD
cd02086 (P-type_ATPase_Na_ENA)
putative cation bi...

808H

putative cation binding site
808H, 812G, 813N, 815A, 816Q, 841E, 844W, 845V
CDD
cd02086 (P-type_ATPase_Na_ENA)

812G

putative cation binding site
808H, 812G, 813N, 815A, 816Q, 841E, 844W, 845V
CDD
cd02086 (P-type_ATPase_Na_ENA)

813N

putative cation binding site
808H, 812G, 813N, 815A, 816Q, 841E, 844W, 845V
CDD
cd02086 (P-type_ATPase_Na_ENA)

815A

putative cation binding site
808H, 812G, 813N, 815A, 816Q, 841E, 844W, 845V
CDD
cd02086 (P-type_ATPase_Na_ENA)

816Q

putative cation binding site
808H, 812G, 813N, 815A, 816Q, 841E, 844W, 845V
CDD
cd02086 (P-type_ATPase_Na_ENA)

841E

putative cation binding site
808H, 812G, 813N, 815A, 816Q, 841E, 844W, 845V
CDD
cd02086 (P-type_ATPase_Na_ENA)

844W

putative cation binding site
808H, 812G, 813N, 815A, 816Q, 841E, 844W, 845V
CDD
cd02086 (P-type_ATPase_Na_ENA)

845V

putative cation binding site
808H, 812G, 813N, 815A, 816Q, 841E, 844W, 845V
CDD
cd02086 (P-type_ATPase_Na_ENA)

Protein sequence

>MIA_00351_1
MDSEKKIPVVHTLSMDPSYMSGNEKSLDMDVKNAPWTLSIEQAANAFETNVTSGLTHDEAKKRLETYGPNQLDQGEGVSM
VKVFLRQVCNAMILVLVISMAISFGIRDWIAGGVIAGVIGINVVVGFIQEYNAEKTMDSLRSLSSPTARVIRNGTDETIP
SIEVVPGDLISVKVGDTIPSDFRVVDSMNFETDEALLTGESLPVAKEQVPVFPLECGVGDRINMAYSSSIVTKGRAIGIC
TSTGMNTEIGVIAMSLRSQNKGFRPVKRDEFGKARKRDYVGAFVGTIKDAIGAFLGVNVGTPLHRKLAQLAILLFGIAVV
FAIVVMAAQKFKVNKEVAIYAIAVALSMIPASLVVVLTITMAVGTKIMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQ
GKMVGRKVWIPTVGTYQVVNSTEAFNPTIGQVTFSPNTPFEDGSEDDVHENIPEPFPKKFTEWLDVASLANIAKVHYEID
ENGAHIWKANGDPTEIAIQVFTHRMDWQRPKWTEGDNPKFSHLAEYPFDSSIKRMTAVYKENATGLTHIFTKGAVERVLN
CCSTWYGGSNPDENGISPLTEDDKEMIMKNMDALAKQGLRVLSFSRKLYNGPENTDWKELDRGNLEKDLHFLGLIGIYDP
PRLESAGAVKLCHKAGINVHMLTGDHPGTAKSIAQEVGILPHNLYHYPEDVVKVMVMTAHQFDSLSDDEIDALPVLPLVI
ARCAPQTKVRMIDALHRRKAFCAMTGDGVNDSPSLKRADVGIAMGIAGSDVAKDASDIVLSDDNFASILNAVEEGRRMAA
NIQKFVLHLLAGNIAQALFLLIGLVFQDEDGISVFPLSPVEVLWVIMITSSFPAMGLGVESAAPDIMERPPVDPKAGVFT
WEVIIDMLVYGLWIAGVCIFSFVVVVYKDGTGKDVLGKNCNNKYTELCYHVFRGRSASFLTMTWCLLLLAWEVIDMRRSL
FAMHPETDTPYTQVFKDLWSNQFLFWSVILGFVSAPPLLYIPVINKDVFKHGPIGWEWGISVASVFIFMIGAEAYKFFKR
MYYRRNRDSPKNPQDDLDNSPFAKYASLSRQNTMEHQTVIIGAAKN

GO term prediction

Biological Process

GO:0006812 cation transport

Molecular Function

GO:0000166 nucleotide binding
GO:0019829 cation-transporting ATPase activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features