Protein
MIA_00177_1
Length
403 amino acids
Browser: contig01:498761-499973+
Protein function
| EGGNOG: | 0PMDY | FG10671.1 | Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) |
|---|---|---|---|
| SGD closest match: | S000000523 | LEU2 | 3-isopropylmalate dehydrogenase |
| CGD closest match: | CAL0000185901 | LEU2 | 3-isopropylmalate dehydrogenase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_04991_1 | 59.024% | 410 | 1.96e-149 | MCA_04991_1 |
| A0A0J9XD73_GEOCN | 56.319% | 364 | 3.84e-128 | 3-isopropylmalate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA08s04762g PE=3 SV=1 |
| A0A167E5C3_9ASCO | 51.232% | 406 | 1.72e-116 | 3-isopropylmalate dehydrogenase OS=Sugiyamaella lignohabitans GN=LEU2 PE=3 SV=1 |
| UniRef50_A0A167E5C3 | 51.232% | 406 | 4.72e-113 | 3-isopropylmalate dehydrogenase n=11 Tax=saccharomyceta TaxID=716545 RepID=A0A167E5C3_9ASCO |
| A0A1E4TM50_9ASCO | 48.250% | 400 | 5.56e-100 | 3-isopropylmalate dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_93497 PE=3 SV=1 |
| LEU3_YEAST | 46.212% | 396 | 2.83e-89 | 3-isopropylmalate dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEU2 PE=1 SV=4 |
| A0A1D8PQK5_CANAL | 45.676% | 370 | 2.48e-88 | 3-isopropylmalate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LEU2 PE=3 SV=1 |
| LEU3_BLAAD | 43.073% | 397 | 7.42e-88 | 3-isopropylmalate dehydrogenase OS=Blastobotrys adeninivorans GN=LEU2 PE=3 SV=1 |
| A0A1E3PPA0_9ASCO | 47.514% | 362 | 3.71e-87 | 3-isopropylmalate dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81723 PE=3 SV=1 |
| LEU3_YARLI | 47.368% | 361 | 4.84e-81 | 3-isopropylmalate dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LEU2 PE=3 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0200
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
403
Detailed signature matches
-
-
PS00470 (IDH_IMDH)
-
no IPR
Unintegrated signatures
-
-
SSF53659 (Isocitrat...)
Protein sequence
>MIA_00177_1 MKTFNILVLPGDHIGPEIVAEAVKILQVVEKYSKQDLKFHLEYDLFGGASIDKHGEPITEQVLKKAEVCDAVLFGSVGGP EWGPSLAVSEGEKAKDTSLIDTVRQNRLKGARPEQGVLELRRRLDCWANIRPVRLLAPALAARVSAIKEHVLRGTDMIVL RENCGGAYFGAKTENANSASDAWAYTRPEIERVTRMAGYLAEHYPGHVDGDSVKITSCDKANVLANSRLWRAVVQQIHDD EFPHIELVHQLADSAAMIMVARPTALNGVVLCDNTFGDILSDEAAALPGSLGLLPSASLAHIPGDGRKAQGLYEPAHGSA PDLPRDAANPVATILSAGMMLRYTCGQPGLADLLDAAVGHVLEDVEAGGLGLRTRDLGGTLGTCSLGDAIANEFKKRLVE SEF
GO term prediction
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0000287 magnesium ion binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Cellular Component
None predicted.