Protein

MIA_00174_1

Length
536 amino acids

Browser: contig01:493652-495263+

Protein function

EGGNOG:0PFIFPGUG_02270Threonine dehydratase
SGD closest match:S000000888ILV1Threonine dehydratase, mitochondrial
CGD closest match:CAL0000199398ILV1Threonine dehydratase

Protein alignments

%idAln lengthE-value
MCA_01588_181.121%5350.0MCA_01588_1
A0A0J9XBE3_GEOCN75.985%5330.0Threonine dehydratase OS=Geotrichum candidum GN=BN980_GECA08s04740g PE=3 SV=1
A0A060SX37_BLAAD71.771%5420.0Threonine dehydratase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A10362g PE=3 SV=1
A0A167E529_9ASCO71.319%5230.0Threonine dehydratase OS=Sugiyamaella lignohabitans GN=ILV1 PE=3 SV=1
UniRef50_O4261570.111%5420.0Threonine dehydratase, mitochondrial n=14 Tax=Eukaryota TaxID=2759 RepID=THDH_BLAAD
A0A1E3PK31_9ASCO67.164%5360.0Threonine dehydratase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46419 PE=3 SV=1
THDH_YEAST63.027%5220.0Threonine dehydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ILV1 PE=1 SV=2
Q6CAI4_YARLI64.583%5280.0Threonine dehydratase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D02497g PE=3 SV=1
A0A1E4TIP4_9ASCO60.526%5320.0Threonine dehydratase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_73669 PE=3 SV=1
Q59P56_CANAL62.183%5130.0Threonine dehydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ILV1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0186

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 500 536

Detailed signature matches

  1. Family IPR005787
    Threonine dehydratase, biosynthetic
    1. TIGR01124
  2. Domain IPR001926
    Tryptophan synthase beta subunit-like PLP-dependent enzyme
    1. SSF53686 (Tryptopha...)
    2. PF00291 (PALP)
  3. Domain IPR001721
    ACT-like domain
    1. PF00585 (Thr_dehydr...)
    2. PS51672 (ACT_LIKE)
  4. SITE IPR000634
    Serine/threonine dehydratase, pyridoxal-phosphate-binding site
    1. PS00165 (DEHYDRATAS...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.10...
  2. G3DSA:3.40.50...
  3. SSF55021 (ACT-like)
  4. cd01562 (Thr-dehyd)
  5. cd04906 (ACT_ThrD-I_1)
  6. cd04907 (ACT_ThrD-I_2)

Residue annotation

  1. tetramer interface...
  2. catalytic residue ...
  3. pyridoxal 5'-phosp...
  4. putative Ile/Val b...
  5. putative Ile/Val b...

Protein sequence

>MIA_00174_1
MSDSKEETPKEQPFSYANIDPSFLLPDGTPDYLKLILTTRVYDVCKETPLTPAVNMSSKLNANILLKREDLQPVFSFKLR
GAYNLIAQLPKEERWKGVIACSAGNHAQGVAYSAQHLNIPATIVMPIATPSIKYQNVARLGSKVVLFGDDFDAAQTECKR
LAKQHGIANIPPFDDPYVIAGQGTIAMEILRQVNIHELKAVFACIGGGGLIAGIGAYIKRIAPHVKVIGIETYDADAMYQ
SLQKGERITLKEVGLFADGTAVKIPGQETFRLCQEVIDEIVHVGTDEICAAIKDVFLETRSIVEPSGALSLAGAKKYISS
HPEVDHSANSYVCVLSGANMNFDRLRFVSERAMLGEGSEVFYVASIPERPGSFEKLISILNPRAITEFSYRYNDPDTANI
YISFSVQDRDTELASIQEQFAQDGTIKGIDISENELAKTHARYLVGGKAKVENERIFRFEFPERPGALFKFLKGIKSQWN
ITLFHYRNHGSDIGKILAGIAVSPKDNELFQEFLDNLAYPYIEETENAIYNLFLKG

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process
GO:0009097 isoleucine biosynthetic process

Molecular Function

GO:0004794 L-threonine ammonia-lyase activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.