Protein

MIA_00167_1

Length
176 amino acids

Browser: contig01:465062-465593+

Protein function

EGGNOG:0PMYYADI1Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity)
SGD closest match:S000004611ADI11,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
CGD closest match:CAL0000199544ADI11,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Protein alignments

%idAln lengthE-value
MCA_05703_157.95%1763e-73MCA_05703_1
A0A0J9X760_GEOCN48.86%1769e-631,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Geotrichum candidum GN=ADI1 PE=3 SV=1
A0A167EBM8_9ASCO52.87%1741e-621,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Sugiyamaella lignohabitans GN=ADI1 PE=3 SV=1
A0A060TBU3_BLAAD50.57%1742e-601,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Blastobotrys adeninivorans GN=ADI1 PE=3 SV=1
MTND_YARLI49.71%1751e-591,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ADI1 PE=3 SV=1
UniRef50_Q6CH0349.71%1753e-561,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase n=129 Tax=Fungi TaxID=4751 RepID=MTND_YARLI
A0A1E3PGB7_9ASCO47.98%1733e-541,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=ADI1 PE=3 SV=1
MTND_YEAST45.14%1755e-491,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADI1 PE=1 SV=1
MTND_CANAL41.38%1744e-411,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADI1 PE=3 SV=1
A0A1E4TEV1_9ASCO44.75%1813e-371,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Tortispora caseinolytica NRRL Y-17796 GN=ADI1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0047

Protein family membership

Domains and repeats

  1. Domain
1 20 40 60 80 100 120 140 160 176

Detailed signature matches

  1. Family IPR004313
    Acireductone dioxygenase ARD family
    1. PF03079 (ARD)
  2. Family IPR027496
    1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes
    1. MF_03154 (Salvage_M...)
  3. Domain IPR014710
    RmlC-like jelly roll fold
    1. G3DSA:2.60.12...
  4. Domain IPR011051
    RmlC-like cupin domain
    1. SSF51182 (RmlC-like...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Protein sequence

>MIA_00167_1
MKAYYHDGRNEEDRSQPHETADKVSIEELNDIGVYLHHFDNIIHVDELSKKRHYMARDEIEISPQSSGNWEAYQKQLDKY
YTEHLHEDEEIRYVLDGAGYFDLRNHTQDRWIRLQVTKGDLVILPAGIYHRFAPTTGNYIKNMRLFQDRPKWLAVNRPEA
DATAFRIKYLKEITSN

GO term prediction

Biological Process

GO:0019509 L-methionine salvage from methylthioadenosine
GO:0055114 oxidation-reduction process

Molecular Function

GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.