MIA_00143_1

Protein

Length

1,813 amino acids

Protein function

EGGNOG:	0PG7Z	EAF1	component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair
SGD closest match:	S000002767	EAF1	Chromatin modification-related protein EAF1
CGD closest match:	CAL0000190942	VID21	Chromatin modification-related protein EAF1

Protein alignments

	%id	Aln length	E-value
MCA_03529_1	42.629%	814	9.48e-178	MCA_03529_1
A0A167D9T3_9ASCO	48.265%	317	3.02e-84	Eaf1p OS=Sugiyamaella lignohabitans GN=EAF1 PE=4 SV=1
UniRef50_A0A167D9T3	48.265%	317	8.29e-81	Eaf1p n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167D9T3_9ASCO
A0A0J9X3A5_GEOCN	47.273%	330	2.81e-82	Similar to Saccharomyces cerevisiae YDR359C EAF1 Component of the NuA4 histone acetyltransferase complex OS=Geotrichum candidum GN=BN980_GECA01s08634g PE=4 SV=1
A0A060T6J4_BLAAD	41.853%	313	2.96e-71	ARAD1C14520p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C14520g PE=4 SV=1
A0A1E3PIB1_9ASCO	36.432%	398	9.61e-66	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_79030 PE=4 SV=1
EAF1_YARLI	41.695%	295	3.21e-61	Chromatin modification-related protein EAF1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=EAF1 PE=3 SV=1
EAF1_YEAST	36.860%	293	2.15e-49	Chromatin modification-related protein EAF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EAF1 PE=1 SV=2
A0A1E4TER2_9ASCO	32.412%	398	3.91e-44	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1928 PE=4 SV=1
EAF1_CANAL	43.617%	188	8.84e-38	Chromatin modification-related protein EAF1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VID21 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0415

Protein family membership

None predicted.

Domains and repeats

Domain
728 - 813
Helicase/SANT-associated domain (IPR014012)
1,217 - 1,278
Homeobox domain-like (IPR009057)
SANT/Myb domain (IPR001005)
Myb-like domain (IPR017877)

1 200 400 600 800 1000 1200 1400 1600 1813

Detailed signature matches

IPR014012

Helicase/SANT-associated domain
1. SM00573 (bromneu2)
  
  729 - 793
  
  SMART
  SM00573 (bromneu2)
2. PS51204 (HSA)
  
  728 - 813
  
  PROSITE profiles
  PS51204 (HSA)
3. PF07529 (HSA)
  
  736 - 778
  
  Pfam
  PF07529 (HSA)
IPR009057

Homeobox domain-like
1. SSF46689 (Homeodoma...)
  
  1,217 - 1,275
  
  SUPERFAMILY
  SSF46689 (Homeodomain-like)
IPR001005

SANT/Myb domain
1. SM00717 (sant)
  
  1,218 - 1,278
  
  SMART
  SM00717 (sant)
IPR017877

Myb-like domain
1. PS50090 (MYB_LIKE)
  
  1,222 - 1,276
  
  PROSITE profiles
  PS50090 (MYB_LIKE)

no IPR

Unintegrated signatures

Coil

1,507 - 1,527

COILS
Coil (Coil)
G3DSA:1.10.10.60

839 - 1,280

GENE3D
G3DSA:1.10.10.60 (G3DSA:1.10.10.60)
PF13921 (Myb_DNA-bi...)

1,222 - 1,281

Pfam
PF13921 (Myb_DNA-bind_6)
cd00167 (SANT)

1,222 - 1,275

CDD
cd00167 (SANT)
mobidb-lite (disord...)

813 - 1,001

MobiDB Lite
mobidb-lite (disorder_prediction)

1,349 - 1,368

MobiDB Lite
mobidb-lite (disorder_prediction)

1,015 - 1,039

MobiDB Lite
mobidb-lite (disorder_prediction)

1,643 - 1,680

MobiDB Lite
mobidb-lite (disorder_prediction)

100 - 605

MobiDB Lite
mobidb-lite (disorder_prediction)

1,382 - 1,405

MobiDB Lite
mobidb-lite (disorder_prediction)

1,765 - 1,813

MobiDB Lite
mobidb-lite (disorder_prediction)

1,521 - 1,575

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

DNA binding site c...

1,222W

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,263R

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,264T

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,266W

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,267Q

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,269F

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,270E

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,271R

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,273L

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,274Q

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

1,275L

DNA binding site
1,222W, 1,263R, 1,264T, 1,266W, 1,267Q, 1,269F, 1,270E, 1,271R, 1,273L, 1,274Q, 1,275L
CDD
cd00167 (SANT)

Protein sequence

>MIA_00143_1
MSAPHMDRLRLEAIEKRRQQSSDLIKSRKRKLSDLYYLTRYPTYPINKSGVQTDEDSLMAYLEKNDLESGHTFDESTLPS
RAIVPNEVLLPAKRARALYSPTATTSSAPTHPPLVPAPPPASTTSPAQKLPSQAPRIATPSPAHAPAGPQQPPLQKQHPA
AHQLPKHSPTAAQQKPPQPAPKPATTPAGSAQTSPAVAHPAVAPTVSPKTSSSASPVASSSPPTTAPAPATPTTTTNPPK
PGNAAPSTTGHLPPQKTTPYKQPQSPLGKPTTATNQQIHSSPPQATANPKQSAPHKPPTGVSAKPGAAPAPTMPANPTKV
LARGPPGGAAQQQQLARGPTTPQPSPLPTAGGPHPQRASVPPTPTNALGSVPVATTLPRAQSTPALLTKAGPKPQLPTQQ
TPRKNSAPDTKVGLRPTAGPLPAKAPLPQKTATPSLGATLNTTKPAAVSTKNLASVPASSSQQPPKQGPPASPALSTKPG
LAPHAGAKTGINLSATAGPKAAGVSAGNASIPARAKSVVAATAPSNNAPQPAGSTMPAAASQQPKTAPSAAKPAMPTTSG
TPLLEKSTEKPADKQPEPNQPATTAPKPRPTTAHAPATRTTQYVSREEFYKRQPSIHQMRQNVTVPDQQVPWYTNPKTVD
PVADKDSDVKILVVPNRLPETVHGRRQLTLPELYYTTQALPVVKLLPAAHKALTTETYQLSFLEAKLAVVHVRIEELKRL
DRWSLRQHAKFRGPLRLKIHWDFLIDEMKWLQQDFSEERRLKIATCFELSQAVLDYWAFGRDVCCIRTKPVTHLDDKPPV
KVVEPLDGDVVMKDSETVGKESLPSYKSPLDTKEEAQSAEIKDKSDDATPLSKDKPSDSLPTCGTQAGSVPEDKQGDTSL
QVAASPVPTKTTSKSNDGERSVTASPSPEEAAVLEIPGEGKAAAAAMAASSATPDISIPDKGPAKEEGQSAAQGGPSAAN
LPKQPAAAPLQNNKSTAGDKSDGPQHPADAASPKDISEAQSFVNLEEALDVVMEEPPKDTPDNRDLPQEPADPYQAKVSS
PETLYASLVFKDDEPDVRPDNTMTITPRDLHDLHDANKIDSLVPKSVFLRDKDQSVRVPLKMFMSLDKMDSASREIFNSL
PLQKPIEDVNTPYISELESLSINSVTKFLAAPDLNPTWQKLIIEVDPPNTKTHHPLPSDEEDEAGHKHPLFQNDQNKRQI
HIRAPQPPNIKYLEYIRMPTIWLQQDDQKLIRVAREFQFNWQVVSATFSHDATLGYTSITERRTPWQCFERWLQLNPNFS
LTELKGPYAQQAVHWISSSVKMQAHTKHRISPIGIVNTDSLPRGHSRLRWASMFEAIRKGMRIRESAIRPPNQIPRKPVQ
TMENSQPVYTPEELSQFKYKADHQASAQYPQRAQQNQMAAAAASAQGTNIGNGNAATTASRPATQGVFPQRISPEQYAQL
LQQQKLRQLQQQQQAAVNQKLQRVVQQQAPVQLTLQQQQQLQMQRAQQQRINATVAAQAPNQQQLNYQQLMLQQQKAQQA
KQAATNAGSPGVASAGSPTMSTVPSPVVSSASPASSSPVVSSAPTPVATPVAASPAPVQTPQQQFQVSNLSRAFQFSAQT
PQVQTFMNQIAEQNPTLTPEQVSQIAKTQIQRILMQQRMISTTAPSAAQGPASAPAAGARAQTAHAAAAPQRQTASAPGG
PVAGMFAVNANTRNIAVTGQQQQQHVAAGGATPNIRAGASVRTTPSPVLQTVRAPGAQQGTPPSGSPAIAARQLVTSAAA
RSPTLATAGVQQMHKQGQPAGALRAGPQAAAKPASNSSTPKPAPAQLPPGTPK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003677 DNA binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_00143_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component