Protein

MCA_mt_19351067

Length
655 amino acids

Gene name: nad5

Description: NADH-ubiquinone oxidoreductase subunit 5

Browser: mtDNA:24743-27175+

RNA-seq: read pairs 0, FPKM 0.0, percentile rank 0.8% (100% = highest expression)

Protein function

Annotation:nad5NADH-ubiquinone oxidoreductase subunit 5
KEGG:K03883ND5 NADH-ubiquinone oxidoreductase chain 5 [EC:1.6.5.3]
EGGNOG:0PTMRCore subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
CGD closest match:CAL0000188422NAD5NADH-ubiquinone oxidoreductase chain 5

Protein alignments

%idAln lengthE-value
A0A0A1I5R0_GEOCN78.88%6060.0NADH-ubiquinone oxidoreductase chain 5 OS=Geotrichum candidum GN=ND5 PE=3 SV=1
MIA_mt_1935096479.77%6030.0MIA_mt_19350964
A0A060RCS4_BLAAD62.26%6280.0NADH-ubiquinone oxidoreductase chain 5 OS=Blastobotrys adeninivorans GN=nd5 PE=3 SV=1
A0A161HIF4_9ASCO67.01%5790.0NADH-ubiquinone oxidoreductase chain 5 OS=Sugiyamaella lignohabitans GN=AWJ20_5368 PE=3 SV=1
UniRef50_G4U51655.88%5780.0NADH-ubiquinone oxidoreductase chain 5 n=3 Tax=Candida TaxID=1535326 RepID=G4U516_9ASCO
NU5M_YARLI57.12%5620.0NADH-ubiquinone oxidoreductase chain 5 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ND5 PE=1 SV=1
NU5M_CANAL51.22%5331e-175NADH-ubiquinone oxidoreductase chain 5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NAD5 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4730
Predicted cleavage: 23

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 655

Detailed signature matches

  1. Family IPR003945
    NADH-plastoquinone oxidoreductase, chain 5
    1. TIGR01974
  2. Domain IPR001516
    NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal
    1. PF00662 (Proton_ant...)
  3. Domain IPR001750
    NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
    1. PF00361 (Proton_ant...)
  4. Domain IPR010934
    NADH dehydrogenase subunit 5, C-terminal
    1. PF06455 (NADH5_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. NON_CYTOPLASM... (N...)
  4. PR01434 (NADHDHGNASE5)
  5. SIGNAL_PEPTIDE (Sig...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. SIGNAL_PEPTID... (S...)
  9. SignalP-TM
  10. TMhelix
  11. TRANSMEMBRANE (Tran...)

Protein sequence

>MCA_mt_19351067
MMFMTIFLPMLGSMLSGLLSRSMGSRSYTMSWMTPNPKWSGMMATSTMVMAALFSYYLYFDVMVNNNIYTLNMSKWIYVE
YLEMDWSFMMDELTVSMLMPVLTVSSLVHIYALGYMSHDPHQPRFFSMLSMFTGFMVVLVTGDNYLVMFVGWEFIGVASY
LLISFWFTRLPAMKSALSAFLMNKFGDTFLSVGLMIIMWTFGSLNYNSIFALSQYMNTDILNLIMLCFVIGATSKSAQLG
LHTWLLSSMEGPTPVSALLHAACLVCAGMYLLIRSSFMLEYSPTMLLVCLWLGGLTTIMAGIMAIASNDIKKIIALSTMS
QLGLMVVAIGLSAYNLSLFHLFCHAMFKALLFMSAGSIMHSVMSESQDMRTYGGFIHYLPVTYICMLMASLSLMAFPGLT
GYYSKDIIIESTLGVYTISGFIVYWLSLSSALLTTIYSMKLLYLVFYNTPNAPKFIYHNLHESSWFMLIPMIMLSFASMF
MGYLTRDIYLGFGSPFNSIFIHPNNLSIIETELSINLTLKLLPLILTILGTVLVLVIYEFKYTWLLMYNNNLLRNIYMFF
NNKFMFDQILNNIILRSNLAISFKLNQFVDKGTLQMIGPRGIYDTLNMAVYNIIKLSTGSLLHFSIYLLSGMMFILLSMF
FNTPLLFIFLMILII

GO term prediction

Biological Process

GO:0042773 ATP synthesis coupled electron transport
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008137 NADH dehydrogenase (ubiquinone) activity

Cellular Component

None predicted.