MCA_mt_19351036

Protein

Length

277 amino acids

Gene name: cox3

Description: Cytochrome c oxidase subunit 3

Browser: mtDNA:3823-4773+

RNA-seq: read pairs 0, FPKM 0.0, percentile rank 0.8% (100% = highest expression)

Protein function

Annotation:		cox3	Cytochrome c oxidase subunit 3
KEGG:	K02262	COX3	cytochrome c oxidase subunit 3
EGGNOG:	0PJUY	COX3	Subunits I, II and III form the functional core of the enzyme complex
SGD closest match:	S000007283	COX3	Cytochrome c oxidase subunit 3
CGD closest match:	CAL0000183335	COX3A	Cytochrome c oxidase subunit 3

Protein alignments

	%id	Aln length	E-value
A0A0A1I5X3_GEOCN	72.59%	270	1e-133	Cytochrome c oxidase subunit 3 OS=Geotrichum candidum GN=cox3 PE=3 SV=1
MIA_mt_19350928	71.38%	276	6e-133	MIA_mt_19350928
A0A060RCV0_BLAAD	60.78%	283	2e-106	Cytochrome c oxidase subunit 3 OS=Blastobotrys adeninivorans GN=cox3 PE=3 SV=1
COX3_YARLI	60.59%	269	1e-94	Cytochrome c oxidase subunit 3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=COX3 PE=3 SV=1
UniRef50_W6DHH1	54.81%	270	6e-88	Cytochrome c oxidase subunit 3 n=7 Tax=Colletotrichum TaxID=5455 RepID=W6DHH1_COLLN
COX3_YEAST	57.62%	269	1e-89	Cytochrome c oxidase subunit 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COX3 PE=3 SV=3
COX3_CANAL	52.40%	271	1e-82	Cytochrome c oxidase subunit 3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=COX3A PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0960
Predicted cleavage: 76

Protein family membership

None predicted.

Domains and repeats

Domain
16 - 277
Cytochrome c oxidase-like subunit III (IPR000298)
Cytochrome c oxidase subunit III domain (IPR033945)
Domain
86 - 277
Cytochrome c oxidase, subunit III, 4-helical bundle (IPR013833)

1 50 100 150 200 250 277

Detailed signature matches

IPR000298

Cytochrome c oxidase-like subunit III
1. PS50253 (COX3)
  
  17 - 277
  
  PROSITE profiles
  PS50253 (COX3)
2. SSF81452 (Cytochrom...)
  
  16 - 276
  
  SUPERFAMILY
  SSF81452 (Cytochrome c oxidase subunit III-like)
3. PF00510 (COX3)
  
  19 - 277
  
  Pfam
  PF00510 (COX3)
IPR033945

Cytochrome c oxidase subunit III domain
1. cd01665 (Cyt_c_Oxid...)
  
  31 - 275
  
  CDD
  cd01665 (Cyt_c_Oxidase_III)
IPR013833

Cytochrome c oxidase, subunit III, 4-helical bundle
1. G3DSA:1.20.12...
  
  86 - 277
  
  GENE3D
  G3DSA:1.20.120.80 (G3DSA:1.20.120.80)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

118 - 145

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

193 - 211

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

276 - 277

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

49 - 54

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.10.28...

14 - 85

GENE3D
G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
NON_CYTOPLASM... (N...)

237 - 255

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

74 - 92

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

168 - 172

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1 - 28

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

94 - 116

TMHMM
TMhelix (TMhelix)

51 - 73

TMHMM
TMhelix (TMhelix)

254 - 276

TMHMM
TMhelix (TMhelix)

212 - 234

TMHMM
TMhelix (TMhelix)

175 - 197

TMHMM
TMhelix (TMhelix)

146 - 168

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

256 - 275

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

55 - 73

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

29 - 48

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

212 - 236

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

173 - 192

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

93 - 117

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

146 - 167

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

Subunit III/VIIa i...

71L

Subunit III/VIIa interface
71L, 74R, 75D, 78A, 81T, 82Y, 83L
CDD
cd01665 (Cyt_c_Oxidase_III)

74R

Subunit III/VIIa interface
71L, 74R, 75D, 78A, 81T, 82Y, 83L
CDD
cd01665 (Cyt_c_Oxidase_III)

75D

Subunit III/VIIa interface
71L, 74R, 75D, 78A, 81T, 82Y, 83L
CDD
cd01665 (Cyt_c_Oxidase_III)

78A

Subunit III/VIIa interface
71L, 74R, 75D, 78A, 81T, 82Y, 83L
CDD
cd01665 (Cyt_c_Oxidase_III)

81T

Subunit III/VIIa interface
71L, 74R, 75D, 78A, 81T, 82Y, 83L
CDD
cd01665 (Cyt_c_Oxidase_III)

82Y

Subunit III/VIIa interface
71L, 74R, 75D, 78A, 81T, 82Y, 83L
CDD
cd01665 (Cyt_c_Oxidase_III)

83L

Subunit III/VIIa interface
71L, 74R, 75D, 78A, 81T, 82Y, 83L
CDD
cd01665 (Cyt_c_Oxidase_III)
Phospholipid bindi...

72W

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

73F

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

76M

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

77V

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

80G

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

86H

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

97G

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

98F

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

101F

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

230F

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

237R

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

249I

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

250G

Phospholipid binding site
72W, 73F, 76M, 77V, 80G, 86H, 97G, 98F, 101F, 230F, 237R, 249I, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)
Subunit I/III inte...

89A

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

92N

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

93G

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

104S

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

107L

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

111G

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

112M

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

118H

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

207G

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

208I

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

211S

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

215L

Subunit I/III interface
89A, 92N, 93G, 104S, 107L, 111G, 112M, 118H, 207G, 208I, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)
Subunit III/VIb in...

134V

Subunit III/VIb interface
134V
CDD
cd01665 (Cyt_c_Oxidase_III)
Subunit III/VIa in...

142T

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

143D

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

144L

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

161Y

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

188A

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

198T

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

199T

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

200A

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

205A

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

206D

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

207G

Subunit III/VIa interface
142T, 143D, 144L, 161Y, 188A, 198T, 199T, 200A, 205A, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)
Subunit III/Vb int...

174Q

Subunit III/Vb interface
174Q
CDD
cd01665 (Cyt_c_Oxidase_III)

Protein sequence

>MCA_mt_19351036
MNNKSNIMLNIYRQNYQLHPFHLVENSPWPFFSSFSLFGLAMNTALTSHGYMQSSIWVILGIVCVAYSMFLWFRDMVAEG
TYLGNHTLAVRNGINLGFILFVVSEALFFIGMFWAFGHSAISPTVEMGAVWPPVGIEAMGPTDLPLLNTMLLLSSGATLT
YSHHYLINGGNRFQVLFGLFLTMLLAVAFMLCQYMEYTTASFTIADGIFGSVFYLGTGFHAMHIMIGVMFLSMSFWRMYS
YQTTSSHHIGYELAVIYWHFVDVVWLMTFVVFYWWGS

GO term prediction

Biological Process

GO:0022904 respiratory electron transport chain

Molecular Function

GO:0004129 cytochrome-c oxidase activity
GO:0015002 heme-copper terminal oxidase activity

Cellular Component

GO:0016020 membrane

Filter view on

Entry type

Status

Per-residue features