Protein

MCA_06504_1

Length
557 amino acids

Gene name: PRC1

Description: Vacuolar carboxypeptidase Y (proteinase C, CPY)

Browser: contigD:4417842-4419516+

RNA-seq: read pairs 14576, FPKM 322.8, percentile rank 92.2% (100% = highest expression)

Protein function

Annotation:PRC1Vacuolar carboxypeptidase Y (proteinase C, CPY)
KEGG:K13289CTSA cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
EGGNOG:0PFU0CPYAVacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity)
SGD closest match:S000004912PRC1Carboxypeptidase Y
CGD closest match:CAL0000177922CPY1Carboxypeptidase

Protein alignments

%idAln lengthE-value
MIA_02230_175.04%5690.0MIA_02230_1
A0A0J9X9R6_GEOCN67.25%5100.0Carboxypeptidase OS=Geotrichum candidum GN=BN980_GECA06s02221g PE=3 SV=1
A0A167E7P7_9ASCO61.36%5280.0Carboxypeptidase OS=Sugiyamaella lignohabitans GN=PRC1 PE=3 SV=1
A0A1D8PRC2_CANAL59.32%5310.0Carboxypeptidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CPY1 PE=3 SV=1
A0A1E3PLB8_9ASCO61.23%5030.0Carboxypeptidase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_22984 PE=3 SV=1
Q6CGJ3_YARLI67.06%4280.0Carboxypeptidase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A18810g PE=3 SV=1
UniRef50_Q6CGJ367.06%4280.0Carboxypeptidase n=12 Tax=Fungi TaxID=4751 RepID=Q6CGJ3_YARLI
A0A060TBY4_BLAAD58.74%4920.0Carboxypeptidase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D35684g PE=3 SV=1
CBPY_YEAST57.43%4980.0Carboxypeptidase Y OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRC1 PE=1 SV=1
A0A1E4TGJ1_9ASCO54.00%5000.0Carboxypeptidase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31721 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2170

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 557

Detailed signature matches

  1. Family IPR001563
    Peptidase S10, serine carboxypeptidase
    1. PF00450 (Peptidase_S10)
    2. PR00724 (CRBOXYPTASEC)
  2. Domain IPR008442
    Propeptide, carboxypeptidase Y
    1. PF05388 (Carbpep_Y_N)
  3. Domain IPR029058
    Alpha/Beta hydrolase fold
    1. SSF53474 (alpha/bet...)
    2. G3DSA:3.40.50...
  4. SITE IPR018202
    Serine carboxypeptidase, serine active site
    1. PS00131 (CARBOXYPEP...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SignalP-noTM

Protein sequence

>MCA_06504_1
MKFSTLSVLSLASMSYAFDFGAFNQFRLGLSNDFKPSSESYRKAQSIISNVASSLGQSWDDIPEGALDVWAEVLQTFPES
VSELQVKTKSSLKSALGRLTSFATGEKPKPAAENDRSWAEFDHKIWSAVTNEELPNHSLRFKSPGNLGIDKTKQYSGYLD
VASGKHLFFWSFESRNDPKKDPVILWLNGGPGCSSLTGLFFELGPARIDKHLKPIHNPYSWNNNATVIFLDQPVNTGYSY
TEGDTVSDTITASKDTYAFLQLFFQQFPEYANLPFHIAGESYAGHYIPVFGSEILSHPERNFNLTSLMIGNGLTDPLRQY
DWYEPMACGKGGAPAVLDDDACQNMINAQPRCNRLIEACYNSQSSWICTPASIYCNNVMMGPYQQTGKNVYDIRTQCGKS
DLCYDDLQYIDDYLNQPAVKQAVGAKVEKYTGCNMDVNRNFLTAGDWMKPYYTAVSDVLAKNIPVLIYAGDKDFICNWLG
NQAWVRQLKWSGSAGMSKAKVEPWIVDGKEAGTKFNHKHFTFLRVYEAGHMVPYNQPKNALAMVNEFIAGNLELKGQ

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004185 serine-type carboxypeptidase activity

Cellular Component

GO:0005773 vacuole