Protein

MCA_06502_1

Length
1,556 amino acids

Gene name: POL1

Description: DNA polymerase alpha catalytic subunit A

Browser: contigD:4411202-4415937-

RNA-seq: read pairs 2412, FPKM 19.1, percentile rank 40.3% (100% = highest expression)

Protein function

Annotation:POL1DNA polymerase alpha catalytic subunit A
KEGG:K02320POLA1 DNA polymerase alpha subunit A [EC:2.7.7.7]
EGGNOG:0PFBMPOL1Dna polymerase
SGD closest match:S000005046POL1DNA polymerase alpha catalytic subunit A

Protein alignments

%idAln lengthE-value
MIA_02228_159.57%12960.0MIA_02228_1
A0A0J9X9U3_GEOCN49.62%15780.0DNA polymerase OS=Geotrichum candidum GN=BN980_GECA06s02254g PE=3 SV=1
UniRef50_A0A0J9X9U349.62%15780.0DNA polymerase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9U3_GEOCN
A0A1E3PG39_9ASCO46.92%12660.0DNA polymerase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_12632 PE=3 SV=1
A0A060TBJ3_BLAAD43.05%12310.0DNA polymerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D35618g PE=3 SV=1
A0A167EMT1_9ASCO45.52%11490.0DNA polymerase OS=Sugiyamaella lignohabitans GN=POL1 PE=3 SV=1
DPOA_YEAST40.41%12820.0DNA polymerase alpha catalytic subunit A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POL1 PE=1 SV=2
Q6C675_YARLI35.10%15700.0DNA polymerase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E11869g PE=3 SV=1
A0A1E4TFY1_9ASCO38.80%12320.0DNA polymerase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_50974 PE=3 SV=1
A0A1D8PR64_CANAL24.21%8225e-38DNA polymerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=POL3 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0155

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1556

Detailed signature matches

  1. Family IPR006172
    DNA-directed DNA polymerase, family B
    1. PR00106 (DNAPOLB)
    2. SM00486 (polmehr3)
  2. Domain IPR024647
    DNA polymerase alpha catalytic subunit, N-terminal domain
    1. PF12254 (DNA_pol_al...)
  3. Domain IPR012337
    Ribonuclease H-like domain
    1. SSF53098 (Ribonucle...)
    2. G3DSA:3.30.42...
  4. Domain IPR006133
    DNA-directed DNA polymerase, family B, exonuclease domain
    1. PF03104 (DNA_pol_B_...)
  5. Domain IPR006134
    DNA-directed DNA polymerase, family B, multifunctional domain
    1. PF00136 (DNA_pol_B)
  6. Domain IPR023211
    DNA polymerase, palm domain
    1. G3DSA:3.90.16...
  7. Domain IPR015088
    Zinc finger, DNA-directed DNA polymerase, family B, alpha
    1. PF08996 (zf-DNA_Pol)
  8. SITE IPR017964
    DNA-directed DNA polymerase, family B, conserved site
    1. PS00116 (DNA_POLYME...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF56672 (DNA/RNA p...)
  2. TIGR00592
  3. cd05532 (POLBc_alpha)
  4. cd05776 (DNA_polB_a...)
  5. mobidb-lite (disord...)

Residue annotation

  1. active site cd05532
  2. metal-binding site...

Protein sequence

>MCA_06502_1
MAEKRRQKLEQLAALRKSGKSSLSAYEVDEGLVYDEVEEEAYRSHYQEDDFVEVNDTNSSYAYQNDYDDIGSKHNNYYSD
DDDANGPFANGKKRSSRSSSKMQTNKRHKVEKEDSPPVPVKNRSKDITEMFKKTTKPKPRKVTIQEEDDLENMLLGLSKK
SKPKDSIAKTKDKERSNAVFTRLEKDPFVSDEDKPNLDVLKFKQEDLDSLNGPDISVSKHVLKEPLETLKTDDFDDFDDF
DDDTEYNSLFPEPDFMDTPKIEKTVIKKEPTEDILVSPIKNHDDKLITVSQPSTPAPVQSDPPETTDWMEINDNLGAVTL
QESSNMYAPRERLKSEDVLEDDGKLRIFWTDYSDFGANLGLFGKVLNKKTGKYSSVFLGVKNISRELYFLPRKNMLNTEA
SENEQESGQLVGIQDVYEEVYEIMAKYGILDFRSKPVKRKYCFELPDVPQETEYLQVLYNYSNNANQILPSDLSGRTFSR
VFGTHTDLFEHFVLTRNIMGPCWLEIESPDFNSINNASWCDLEVGVDSPLHVSVLPDTISLPTPPMNFMSLSIRTIMNRK
DNRQEIAAISGRIYSEIEHDTTTPPEKIPSILFSFIRPIHGVFPMGFERELAKHEEHSTIKTFKDESSMLEEFLKQVSKF
DPDVYIGHALENVVFNIISHRIHIKKVRGWSVLGRRKFNAWPRGFGRGNDLHAQNMVATGRLLLDISNTYGQSLTNKCDS
WTLTEMVKLYLNGKNRLDQPIDASKSNWAVTASGLYQFIVHNEMDTYFSVAIALKTQMLALSKQLTNLAGNSWARTLMGT
RSERNEFILLHEFHRQNYITPDKQSFFSKKKHNTGHNIKNDNKTDSDNRNEPLSKKKDKYKGGLVFEPEKGLYDKIILVM
DFNSLYPSIIQEFNICFTTVDRHDYNLKQSEHLKTLENGENTEPSEDIEEQVLEVPDRNLDMGIFPKLVQTLVKRRRLVK
AHMKDPKATPTQLAQYDIKQQALKLTANSMYGCLGFTKSRFYARPLAVMTTFKGREILMATKALAESIGLQVIYGDTDSV
MINTNVETYEEAIKIGNDFKRQVNQRYRLLEIDIDNVFRRMLLHSKKKYAAVIMKGPEDDKPDPTKPLNIEVKGLDMKRR
EYCQLTKEASKYALDQILGVDSAETSIENIHDYLRNIANKVRNNEIALGKFVIRNRLGKNPKDYPGGSNLPHVVVAQRLI
DNGDVVKPDDVISYIVVIINDETSDEKKSEEELFNKRHVAQRALTLKEIEDAQGKYVPDPEYYLSKQILPPLERLVAPVQ
GTDSVRLAECLGLDVAKYQARLDHANSNGSNSAFNAFKPFQSTIDDSERFRNSKNLLLQCNSCQHVFAFLGLTQQQNGVF
GMTSEGVICPECQEVFEMTTVNAQLESQIRSEISLYYAGYVVCEECNTRSRALGVYGQRCIQMIESTGNGASSGTSFQQC
GGLVSFEYSDLDVYNQMLYYESLFDVDTAMKKAEQKYEKLANAAKRSGGDSGEADTEDNKKINELVFKARDQYLKTKALA
ERNRLRFSVPKQVIEKYMSQCGRRYVDMKDIFSFMA

GO term prediction

Biological Process

GO:0006260 DNA replication

Molecular Function

GO:0000166 nucleotide binding
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity

Cellular Component

None predicted.