Protein

MCA_06426_2

Length
421 amino acids

Gene name: PPH3

Description: Serine/threonine-protein phosphatase 4 catalytic subunit

Browser: contigD:4175264-4176530+

RNA-seq: read pairs 704, FPKM 20.6, percentile rank 42.2% (100% = highest expression)

Protein function

Annotation:PPH3Serine/threonine-protein phosphatase 4 catalytic subunit
KEGG:K15423PPP4C serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
EGGNOG:0PGS9PPH3serine threonine-protein phosphatase
SGD closest match:S000002482PPH3Serine/threonine-protein phosphatase 4 catalytic subunit
CGD closest match:CAL0000195388PPH3Serine/threonine-protein phosphatase

Protein alignments

%idAln lengthE-value
MIA_06275_195.41%1964e-136MIA_06275_1
A0A0J9XCU0_GEOCN94.39%1961e-134Serine/threonine-protein phosphatase OS=Geotrichum candidum GN=BN980_GECA10s03123g PE=3 SV=1
A0A1E3PNC6_9ASCO83.67%1964e-119Serine/threonine-protein phosphatase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50732 PE=3 SV=1
A0A167ET31_9ASCO84.69%1962e-117Serine/threonine-protein phosphatase OS=Sugiyamaella lignohabitans GN=PPH3 PE=3 SV=1
UniRef50_A0A167ET3184.69%1966e-114Serine/threonine-protein phosphatase n=8 Tax=Eukaryota TaxID=2759 RepID=A0A167ET31_9ASCO
Q6C264_YARLI77.16%1972e-110Serine/threonine-protein phosphatase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F10505g PE=3 SV=1
A0A060T8L1_BLAAD80.61%1966e-109Serine/threonine-protein phosphatase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C29634g PE=3 SV=1
A0A1E4TM53_9ASCO72.96%1963e-104Serine/threonine-protein phosphatase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_94195 PE=3 SV=1
A0A1D8PSJ8_CANAL70.98%1931e-99Serine/threonine-protein phosphatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PPH3 PE=3 SV=1
PP4C_YEAST66.33%1962e-90Serine/threonine-protein phosphatase 4 catalytic subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPH3 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1406

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 421

Detailed signature matches

  1. Domain IPR029052
    Metallo-dependent phosphatase-like
    1. SSF56300 (Metallo-d...)
    2. G3DSA:3.60.21.10
  2. Domain IPR004843
    Calcineurin-like phosphoesterase domain, ApaH type
    1. PF00149 (Metallophos)
  3. Domain IPR006186
    Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    1. PS00125 (SER_THR_PH...)
    2. SM00156 (pp2a_7)
    3. PR00114 (STPHPHTASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd07415 (MPP_PP2A_P...)
  2. mobidb-lite (disord...)

Residue annotation

  1. heterotrimer inter...
  2. metal binding site...
  3. active site cd07415

Protein sequence

>MCA_06426_2
MSLVDETIELLRTFRHVPEEMVKQLCYKAQDLLVEESNVQLVYTPVTICGDIHGQFHDLLELFNVGGECPFTNYLFLGDF
VDRGFYSVESFLLLLCLKVRYPDRITLIRGNHESRQITTTYGFYDECIRKYGSSYVWRLCCNVFDYLALSALVGGPKGVF
CVHGGLSPSIKYINQIRTIDRKQEVPHDGPMCDLLWSDPDDTSNLDDEDEDGELGLSSGQDDDFNMYLIDSKSSSQLNDN
SNDSVANFNNDINENDEDENKTYTTNNDKNNDSTKTSNNNDLNIYDNSYDNIANDQQSMINSNNSPTYPSSMSHPQWSLS
PRGAGYVFGPTPVYAFNHLNNTSLIARAHQLVVEGYKEIYNEQLVTVWSAPNYCYRCGNVAAILQIDDNLERNYKVFEAQ
ITELQGSKLMPMKRPVPEYFL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016787 hydrolase activity

Cellular Component

None predicted.