MCA_06423_1

Protein

Length

634 amino acids

Gene name: SIT1C

Description: Siderophore iron transporter

Browser: contigD:4156880-4158785-

RNA-seq: read pairs 940, FPKM 18.3, percentile rank 39.0% (100% = highest expression)

Protein function

Annotation:		SIT1C	Siderophore iron transporter
KEGG:	K08197	ARN	MFS transporter, SIT family, siderophore-iron:H+ symporter
EGGNOG:	0QE3E	FG05848.1	transporter
SGD closest match:	S000000791	SIT1	Siderophore iron transporter 1
CGD closest match:	CAL0000196424	SIT1	Siderophore transporter

Protein alignments

	%id	Aln length	E-value
MIA_01603_1	63.30%	545	0.0	MIA_01603_1
A0A167ED34_9ASCO	58.67%	571	0.0	Sit1p OS=Sugiyamaella lignohabitans GN=SIT1 PE=4 SV=1
A0A0J9XET3_GEOCN	59.80%	602	0.0	Similar to Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter OS=Geotrichum candidum GN=BN980_GECA12s01770g PE=4 SV=1
A0A1E4TLQ4_9ASCO	55.07%	572	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30763 PE=4 SV=1
A0A1E3PN76_9ASCO	56.45%	574	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21345 PE=4 SV=1
A0A060T0V0_BLAAD	58.06%	558	0.0	ARAD1C11330p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C11330g PE=4 SV=1
UniRef50_A0A1X7R3Q1	50.99%	557	1e-177	Similar to Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates n=1 Tax=Kazachstania saulgeensis TaxID=1789683 RepID=A0A1X7R3Q1_9SACH
SIT1_YEAST	48.22%	591	8e-174	Siderophore iron transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIT1 PE=3 SV=1
Q5A2T6_CANAL	43.61%	587	5e-161	Siderophore transporter OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SIT1 PE=4 SV=1
Q6CE20_YARLI	27.59%	569	2e-53	YALI0B19250p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B19250g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0918

Protein family membership

Siderophore iron transporter 1/trichothecene efflux pump Tri12 (IPR010573)

Domains and repeats

Domain
75 - 517
Major facilitator superfamily domain (IPR020846)
561 - 591
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 634

Detailed signature matches

IPR010573

Siderophore iron transporter 1/trichothecene efflux pump Tri12
1. PF06609 (TRI12)
  
  108 - 521
  
  Pfam
  PF06609 (TRI12)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  339 - 511
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  561 - 591
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  76 - 263
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  75 - 517
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

338 - 356

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

469 - 565

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

416 - 423

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

131 - 141

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

250 - 287

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

185 - 195

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 74

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

594 - 617

COILS
Coil (Coil)
G3DSA:1.20.12...

69 - 265

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

342 - 597

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

215 - 225

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

445 - 449

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

374 - 392

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

309 - 319

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

161 - 165

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

586 - 634

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

92 - 110

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

566 - 585

TMHMM
TMhelix (TMhelix)

450 - 472

TMHMM
TMhelix (TMhelix)

140 - 159

TMHMM
TMhelix (TMhelix)

423 - 445

TMHMM
TMhelix (TMhelix)

487 - 509

TMHMM
TMhelix (TMhelix)

318 - 337

TMHMM
TMhelix (TMhelix)

289 - 311

TMHMM
TMhelix (TMhelix)

228 - 250

TMHMM
TMhelix (TMhelix)

73 - 90

TMHMM
TMhelix (TMhelix)

193 - 215

TMHMM
TMhelix (TMhelix)

396 - 418

TMHMM
TMhelix (TMhelix)

357 - 375

TMHMM
TMhelix (TMhelix)

166 - 188

TMHMM
TMhelix (TMhelix)

111 - 130

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

196 - 214

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

393 - 415

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

75 - 91

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

111 - 130

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

226 - 249

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

320 - 337

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

450 - 468

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

424 - 444

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

566 - 585

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

142 - 160

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

166 - 184

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

357 - 373

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

288 - 308

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 23

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

88Y

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

91D

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

92M

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

93N

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

95R

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

96Y

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

116S

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

119T

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

120S

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

123S

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

127Q

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

128P

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

130F

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

131A

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

177Y

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

200G

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

203V

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

204P

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

207P

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

208F

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

211N

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

223G

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

224T

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

227Q

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

228W

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

234G

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

368N

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

371W

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

372Y

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

375G

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

376E

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

379Y

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

393A

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

397T

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

401S

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

404S

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

408G

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

460G

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

463A

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

464G

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

467T

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

471Q

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

472A

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

475Q

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

486V

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

487T

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

490Y

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

491L

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

494Y

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

495Q

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

498S

putative substrate translocation pore
88Y, 91D, 92M, 93N, 95R, 96Y, 116S, 119T, 120S, 123S, 127Q, 128P, 130F, 131A, 177Y, 200G, 203V, 204P, 207P, 208F, 211N, 223G, 224T, 227Q, 228W, 234G, 368N, 371W, 372Y, 375G, 376E, 379Y, 393A, 397T, 401S, 404S, 408G, 460G, 463A, 464G, 467T, 471Q, 472A, 475Q, 486V, 487T, 490Y, 491L, 494Y, 495Q, 498S
CDD
cd06174 (MFS)

Protein sequence

>MCA_06423_1
MSEFKHEAPARDPITDTYNRDATYDKKSLDSKDIKEKEEDSSLDEPVEKKLLEEKSYGIRKIEIISKQYQMKGRIMIFFF
IFLVSYCYGLDMNVRYTYQTQAQSSFGTHSLLSTVSVATSIISVASQPFFARLSDVFGRVELIMICIFFYVIGTIVEATA
KNVHQYAAGAIIFQFGYTGLQLLLQLLVGDLSLLNWRLLGSFVPALPFVINTWASGSITQRMGTKWQWGIGMWGIITPVV
SIPLIVGLYHMKYLAKRSGDLDKLDGKSDYRRLGLWGFLKFLFFKVDLIGLVLLVGVFAMILIPLTLAGGVSEKWKEARI
IAPLVIGFCFIPLFIVWEWKGAPVPIIPFSLLKDRGVWAALCIAILFNFTWYMQGEYMYSVLIVAVNQSVASATRITSLY
SFVSVITGSLFGILVSRVRYLKPFIIWGACCWITAIGMLIHFRGGEESKNGIIGSLCFLGFAAGFFTYPTQASIQSCTDH
EHMGVVTSLYLSSYQIGSALGGCVSGAIWTQTLYNNISKELAKVGMTDPTVVNQAYGSPFEFIVTYTWGTPERNAIVIAY
RHVQRLLLIAGVCLCVPLLFLTFFLRNYKLISAQNRFDTEIQNDEKIKRELEEEEQKKIVVEKSGIVAKLRNLI

GO term prediction

Biological Process

GO:0006810 transport

Molecular Function

None predicted.

Cellular Component