MCA_06421_1

Protein

Length

611 amino acids

Gene name: SIT1A

Description: Siderophore iron transporter

Browser: contigD:4145035-4146930-

RNA-seq: read pairs 708, FPKM 14.3, percentile rank 33.0% (100% = highest expression)

Protein function

Annotation:		SIT1A	Siderophore iron transporter
KEGG:	K08197	ARN	MFS transporter, SIT family, siderophore-iron:H+ symporter
EGGNOG:	0QE3E	FG05848.1	transporter
SGD closest match:	S000000791	SIT1	Siderophore iron transporter 1
CGD closest match:	CAL0000196424	SIT1	Siderophore transporter

Protein alignments

	%id	Aln length	E-value
MIA_01603_1	59.44%	572	0.0	MIA_01603_1
A0A0J9XET3_GEOCN	60.92%	568	0.0	Similar to Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter OS=Geotrichum candidum GN=BN980_GECA12s01770g PE=4 SV=1
A0A167ED34_9ASCO	57.84%	555	0.0	Sit1p OS=Sugiyamaella lignohabitans GN=SIT1 PE=4 SV=1
A0A1E4TLQ4_9ASCO	54.27%	562	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30763 PE=4 SV=1
A0A1E3PN76_9ASCO	55.57%	574	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21345 PE=4 SV=1
A0A060T0V0_BLAAD	55.54%	587	0.0	ARAD1C11330p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C11330g PE=4 SV=1
UniRef50_A0A1L0DCD9	48.35%	577	0.0	CIC11C00000005578 n=2 Tax=[Candida] intermedia TaxID=45354 RepID=A0A1L0DCD9_9ASCO
SIT1_YEAST	50.89%	562	0.0	Siderophore iron transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIT1 PE=3 SV=1
Q5A2T6_CANAL	43.00%	586	3e-168	Siderophore transporter OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SIT1 PE=4 SV=1
Q6C0X7_YARLI	27.06%	547	3e-60	YALI0F20922p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20922g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0066

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
69 - 492
Major facilitator superfamily domain (IPR020846)
538 - 566
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 611

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  78 - 478
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  538 - 566
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  316 - 488
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  69 - 260
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  72 - 492
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

182 - 192

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

393 - 400

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

313 - 332

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 71

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

563 - 611

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

247 - 269

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

128 - 138

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

446 - 465

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

63 - 260

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

325 - 578

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

420 - 424

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

289 - 293

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

214 - 224

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

351 - 369

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

487 - 542

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

89 - 107

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

158 - 162

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

297 - 314

TMHMM
TMhelix (TMhelix)

227 - 246

TMHMM
TMhelix (TMhelix)

133 - 153

TMHMM
TMhelix (TMhelix)

333 - 350

TMHMM
TMhelix (TMhelix)

540 - 562

TMHMM
TMhelix (TMhelix)

397 - 419

TMHMM
TMhelix (TMhelix)

429 - 451

TMHMM
TMhelix (TMhelix)

163 - 185

TMHMM
TMhelix (TMhelix)

106 - 128

TMHMM
TMhelix (TMhelix)

464 - 486

TMHMM
TMhelix (TMhelix)

72 - 91

TMHMM
TMhelix (TMhelix)

190 - 212

TMHMM
TMhelix (TMhelix)

270 - 287

TMHMM
TMhelix (TMhelix)

370 - 392

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

294 - 312

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

72 - 88

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

333 - 350

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

425 - 445

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

139 - 157

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

466 - 486

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

225 - 246

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

270 - 288

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

401 - 419

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

370 - 392

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

543 - 562

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

163 - 181

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

108 - 127

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

193 - 213

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 41

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

85Y

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

88D

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

89M

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

90N

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

92R

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

93Y

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

113A

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

116T

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

117S

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

120A

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

124Q

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

125P

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

127F

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

128A

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

174L

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

175T

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

178Q

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

179L

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

182Q

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

183L

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

186G

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

198S

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

199F

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

202A

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

203L

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

209T

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

345N

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

348W

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

349H

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

352G

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

353D

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

356F

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

370A

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

374T

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

378S

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

381S

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

385G

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

437G

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

440A

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

441G

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

444T

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

448Q

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

449A

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

452Q

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

463V

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

464T

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

467Y

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

468L

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

471Y

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

472N

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

475S

putative substrate translocation pore
85Y, 88D, 89M, 90N, 92R, 93Y, 113A, 116T, 117S, 120A, 124Q, 125P, 127F, 128A, 174L, 175T, 178Q, 179L, 182Q, 183L, 186G, 198S, 199F, 202A, 203L, 209T, 345N, 348W, 349H, 352G, 353D, 356F, 370A, 374T, 378S, 381S, 385G, 437G, 440A, 441G, 444T, 448Q, 449A, 452Q, 463V, 464T, 467Y, 468L, 471Y, 472N, 475S
CDD
cd06174 (MFS)

Protein sequence

>MCA_06421_1
MNGYRNEAPARDPAIDPYYDTASPNDSYGVDHKASSDSPSYPLDEKQLLVEKSYGIRKIEIISKQYGPRRRVMVFFFIFL
VAYCYGLDMNVRYSFQATAQSSFGTHSLLSTVAVATSIIAAAAQPLFARLSDVFGRVELVLISILFYIVGTVVEATAKNV
NQYAAGAIIYQFGLTGIQLLFQLLVGDFSLLNWRLLSSFIPALPFIINTWISGNIVNNLRDDWEWGIGMWAIIVPVASIP
LILSLLHMKQLAKRSGDLDELKGKSDYRRLGLWALAMILVPLTLAGGVSQEWKQARIIAPLVVGFCFVPLFISWEWKGAP
VPIIPFSLLKDRGIWAALCIAVLFNFTWHMQGDYMFSVLQVAVNQTPGSATRITSLYSFVSVITGTIFGIVVSRVRYLKP
FIVFGACCWVTAMGMLIHFRGGEGAKNGIIGSLCFLGFAAGFFTYPIQASIQSCTDHEHMAVVTSLYLASYNVGSALGGC
VSGAIWTQTLFNDISREMAAIGVTDEAVVTQAYGSPFDFILTYTWDTPERQAVVAAYRHVQRLLLITAVCLSVPILILTL
FLRNHKLISAQNRFDPEIQNDEKVRRELEEEKRKNMVSEKSGVFAKIKGIF

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features