Protein

MCA_06405_1

Length
1,420 amino acids

Gene name: SGS1A

Description: ATP-dependent helicase SGS1

Browser: contigD:4113113-4117438+

RNA-seq: read pairs 821, FPKM 7.1, percentile rank 20.8% (100% = highest expression)

Protein function

Annotation:SGS1AATP-dependent helicase SGS1
KEGG:K10901BLM bloom syndrome protein [EC:3.6.4.12]
EGGNOG:0PHD9SGS1helicase
SGD closest match:S000004802SGS1ATP-dependent helicase SGS1
CGD closest match:CAL0000185821SGS1ATP-dependent DNA helicase

Protein alignments

%idAln lengthE-value
UniRef50_A0A1E4S70847.11%6417e-180ATP-dependent DNA helicase n=2 Tax=Cyberlindnera jadinii TaxID=4903 RepID=A0A1E4S708_CYBJA
SGS1_YEAST50.28%5370.0ATP-dependent helicase SGS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SGS1 PE=1 SV=1
A0A0J9XHM1_GEOCN51.07%5600.0Similar to Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family OS=Geotrichum candidum GN=BN980_GECA15s01264g PE=4 SV=1
MIA_05465_147.59%5614e-167MIA_05465_1
Q6BZP6_YARLI48.81%5471e-168YALI0F31977p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F31977g PE=4 SV=1
A0A060T609_BLAAD45.41%5554e-163ARAD1B15840p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15840g PE=4 SV=1
Q5A5R4_CANAL48.68%5302e-161ATP-dependent DNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SGS1 PE=4 SV=1
A0A1E4TE35_9ASCO50.79%5066e-166Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24928 PE=4 SV=1
A0A167CYR1_9ASCO43.36%5654e-153ATP-dependent DNA helicase SGS1 OS=Sugiyamaella lignohabitans GN=SGS1 PE=4 SV=1
A0A1E3PG93_9ASCO43.09%6012e-153ATP-dependent DNA helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_27084 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0509

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 200 400 600 800 1000 1200 1420

Detailed signature matches

  1. Family IPR004589
    DNA helicase, ATP-dependent, RecQ type
    1. TIGR00614
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. Domain IPR032284
    ATP-dependent DNA helicase RecQ, zinc-binding domain
    1. PF16124 (RecQ_Zn_bind)
  7. Domain IPR011991
    Winged helix-turn-helix DNA-binding domain
    1. G3DSA:1.10.10.10
    2. SSF46785 ("Winged h...)
  8. Domain IPR018982
    RQC domain
    1. SM00956 (RQC_2)
    2. PF09382 (RQC)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.15...
  3. G3DSA:3.40.50...
  4. cd00046 (DEXDc)
  5. cd00079 (HELICc)
  6. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...

Protein sequence

>MCA_06405_1
MKTNISDQILWLEKTKSNIPVDLLPVTPNTNSVETDARETYNAPIMANRTNPETPQINKSNPFFPASSSSKVNGNSNISK
AFQISPFADQFPRRTSGNLLSLNSPLNSSNNSSLFNDTSSTKRVSPSPPVSNKRPRKSKLTETSRFNLTNSDDSKNDGDS
DLEEIAFEPASKVNKNITSSEDHSIIPTPAKPLNKQTSILESAVANSTPKNSSTPNPASTNPAPLTNNFSSVQTPQTSEV
NNFWDIDFDDSDDGDFFPSPVKPKTTLPTRSNIIPESPIPTINSPETSLEKQDTHNTPQPPSSAPVPGSVSGSALGSSAL
SSSQKTRQATLQSIVKKCQYIDLCGSILNVNPQISLDKLLEVSKVLDSTLTCVKNFLTENSNELHLTNYQKGLQEDLDLA
LQNLQCERDTYTVQDSLITKSNEPRNNPSTKSPKPDEVGTTDLSDGRTLDNRHSSNEIQSSGQAKPPEINDEIAFIDDFD
NSDFDENFDPFDSIDKSIRDHTVLTINTTDAPNDSTNGSNFQYDDLQEISGFSSAQNGQIIIDDDFSEDRETDLDIIDSF
ESEDGKRQEQDYPVIISDNDPPEQSNQYSTYVETDPEEDGKKYPWSDEVISVLHDTFNLDRFRPNQLKAINSTLEGKDVF
VLMPTGGGKSLCYQLPAVVKKNGKSQGTTIVISPLVSLMQDQVTHLRKKNIKVEQLSSASRNKKSIMNGFRSGEISLLYV
SPEMLAINKDLQHTMKDLHNRGRLPRIVIDEAHCMSSWGHDFRPDYEKLKYLKNDYPNTSIMALTATANMRVQQDIVGCF
RNKDFVFLKQSFNRTNLFYAVAPKTTDDKALAEISQEIHTKFPNQSGIVYCHSQRSCETSADALCKMGVSAASYHAGMTL
QEKTRTQTMWQNDQIKVVCATIAFGMGIDKADVRFVYHLTLPKNMEGYYQETGRGGRDGLPSYCKLFYSWGDAIKITKII
NFDDATTPQMKAHNTELLRSVTHYCNNFLDCRREIVLSYFNETFDRRMCRKTCDNCQMRETRVLETRDITERCKKILAMV
ISITSNGERFTTNHCVSVYRGAQTRQVKEVRHDRIAKFYGDGKSLPKTEVERIMQTMIVEGILFEYLVTNTAGYQTTYVR
AGPRAADLLNGSMGKITIDVISENSLTSSTPRRANTNNVTKTTTTTTTMTTAFDKYQYNNNSNNNSNGDKSNNNSRSISQ
SVSSISSNDKSNSLAKAYSTITTTTTKVSKRNDGDKAKKSKSGTNEERKKFEFHCYGVLEVARLRAKHENNLSNLEEVCS
FDTLKEVALRLPKNLEEFSQIPGVSPDQFIYWPYFYQEIQPLIEKKQKLGFDENDDQNYDEGNDSAEQQQEENNINNNNE
SQKSPFFSKSGTTINNKSSRTNKSRAHSNTDSTRMTTSAKRSHTIPSSQDMTSSIPHMPF

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity

Cellular Component

None predicted.